个人简历

学历背景：
1997.09-2000.06：北京大学公共卫生学院，博士
1994.09-1997.06：华中科技大学同济医学院，硕士
1989.09-1994.06：华中科技大学同济医学院，学士

国外学习研究经历：
2004.08-2006.05：加拿大多伦多大学/安大略省肿瘤研究所，博士后
2003.08-2004.08：美国斯坦福大学，医学院，博士后
2000.06-2003.08：加拿大麦克马斯特大学，生物化学系，博士后
1998.10-1999.09：日本富山医科药科大学，研究生院，博士生
工作经历：
2014.06 -- 至今：苏州大学，药学院药理学系，教授，博士生导师
2012.01-2012.02: 多伦多儿童医院，SPARC生物中心，访问研究员
2009.09-2014.06：苏州大学，唐仲英血液学研究中心，教授，博士生导师
2006.05-2009.09：加拿大多伦多大学/安大略省肿瘤研究所，Scientific Associate

研究领域

（1）肿瘤分子生物学：蛋白质泛素化在肿瘤发生发展和治疗中的作用。
（2）肿瘤药理学：恶性肿瘤尤其是血液肿瘤的药物治疗机制。
（3）抗肿瘤新药研究：以肿瘤特异性分子事件为靶标发现新的抗肿瘤小分子药物

近期论文

[1] Du Y#, Liu Y#, Xu Y, Juan J, Zhang Z, Xu Z, Cao B, Wang Q, Zeng Y*, Mao X*. The transmembrane protein TMEPAI induces myeloma cell apoptosis by promoting degradation of the c-Maf transcription factor. J Biol Chem. 2018 Feb 21. pii: jbc.RA117.000972. doi: 10.1074/jbc.RA117.000972. [Epub ahead of print]
[2] Zhong Y, Meng F, Deng C, Mao X*, Zhong Z*.Targeted inhibition of human hematological cancers in vivo by doxorubicin encapsulated in smart lipoic acid-crosslinked hyaluronic acid nanoparticles.Drug Deliv. 2017 Nov;24(1):1482-1490.
[3] Wang S#, Juan J#, Zhang Z#, Du Y, Xu Y, Tong J, Cao B, Moran MF, Zeng Y*, Mao X*.Inhibition of the deubiquitinase USP5 leads to c-Maf protein degradation and myeloma cell apoptosis. Cell Death Disease, 2017 Sep 21;8(9):e3058. doi: 10.1038/cddis.2017.450.
[4] Wang S#, Li J#, Du Y, Xu Y, Wang Y, Zhang Z, Xu Z, Zeng Y, Mao X*, Cao B*. The Class I PI3K inhibitor S14161 induces autophagy in malignant blood cells by modulating the Beclin 1/Vps34 complex. J Pharmacol Sci. 2017;134:197-202. doi: 10.1016/j.jphs.2017.07.001.
[5] Xu Y#, Zhang Z#, Li J#, Tong J, Cao B, Taylor P, Tang X, Wu D, Moran M, Zeng Y, Mao X*. The ubiquitin conjugating enzyme UBE2O modulates c-Maf stability and induces myeloma cell apoptosis. J Hematol Oncol, 2017 Jul 3;10(1):132. doi: 10.1186/s13045-017-0499-7.
[6] Tang S, Shen H, Mao X, Dai H, Zhu X, Xue S, Ding Z, Lu J, Wu D, Tang X*. FLT3-ITD with DNMT3A R882 double mutation is a poor prognostic factor in Chinese patients with acute myeloid leukemia after chemotherapy or allogeneic hematopoietic stem cell transplantation. Int J Hematol. 2017 Jun 14. doi: 10.1007/s12185-017-2256-7.
[7] Xu Z, Hao Y, Ren L, Zhang Z, Xu X, Cao B, Dai K, Zhu L, Fang Q*, Kong Y,* Mao X*. A novel STAT3 inhibitor negatively modulates platelet activation and aggregation. Acta Pharm Sina, 2017. Mar 6. doi: 10.1038/aps.2016.155.
[8] Mao H#, Du Y#, Zhang Z, Cao B, Zhao J, Zhou H*, Mao X*. Nitroxoline displays anti-myeloma activity by targeting the TRIM25/p53 axle. Anti-cancer Drugs, 2017; 28(4):376-383. doi: 10.1097/CAD.0000000000000466.
[9] Yang J, Tu Z, Xu X, Luo J, Yan X, Ran C, Mao X, Ding K, Qiao C*. Novel conjugates of endoperoxide and 4-anilinoquinazoline as potential anticancer agents. Bioorg Med Chem Lett. 2017 Mar 15;27(6):1341-1345. doi: 10.1016/j.bmcl.2017.02.023
[10] Tong J, Cao B, Martyn GD, Krieger JR, Taylor P, Yates B, Sidhu SS, Li SS, Mao X, Moran MF*. Protein-phosphotyrosine proteome profiling by superbinder-SH2 domain affinity purification mass spectrometry, sSH2-AP-MS. Proteomics. 2017 Mar;17(6). doi: 10.1002/pmic.201600360.
[11] Zeng Y#,*, Xu X#, Wang S, Zhang Z, Liu Y, Han K, Cao B, Mao X*. Ring finger protein 6 promotes breast cancer cell proliferation by stabilizing estrogen receptor alpha. Oncotarget. 2017 Feb 16. doi: 10.18632/oncotarget.15384.
[12] Xu X, Han K, Zhu J, Mao H, Lin X, Zhang Z, Cao B, Zeng Y*, Mao X*. An inhibitor of cholesterol absorption displays anti-myeloma activity by targeting the JAK2-STAT3 signaling pathway. Oncotarget. 2016 Sep 26. doi: 10.18632/oncotarget.12265
[13] Xu X#, Han K#, Tang X#, Zeng Y, Lin X, Zhao Y, Zhang Z, Cao B, Wu D, Mao X*. The ring finger protein RNF6 induces leukemia cell proliferation as a direct target of pre-B-cell leukemia homeobox 1. J Biol Chem. 2016;291(18):9617-28.
[14] Mao H#, Wang M#, Cao B, Zhou H, Zhang Z*, Mao X*. Interferon-stimulated gene 15 induces cancer cell death by suppressing the NF-κB signaling pathway. Oncotarget. 2016 Sep 21. doi: 10.18632/oncotarget.12160.
[15] Zhang Z, Tong J, Tang X, Juan J, Cao B, Hurren R, Chen G, Taylor P, Xu X, Shi C, Du J, Hou J, Wang G, WuD, Stewart A, Schimmer A, Moran M, Mao X*.The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice. Blood, 2016;127(13):1676-86. pii: blood-2015-07-658203.
[16] Zhang Z#, Mao H#, Du X#, Zhu J, Xu Y, Wang S, Xu X, Ji P, Yu Y, Cao B, Han K, Hou T, Xu Z, Kong Y, Jiang G, Tang T, Qiao C, Mao X*. A novel small molecule agent displays potent anti-myeloma activity by inhibiting the JAK2-STAT3 signaling pathway. Oncotarget, 2016. doi: 10.18632/oncotarget.6974.
[17] Yuan N, Song L, Zhang S, Lin W, Cao Y, Xu F, Fang Y, Wang Z, Zhang H, Li X, Wang Z, Cai J, Wang J, Zhang Y, Mao X, Zhao W, Hu S, Chen S, Wang J. Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia. Haematologica. 2015 Mar;100(3):345-56.
[18] Ji P, Xu X, Ma S, Fan J, Zhou Q, Mao X*, Qiao C*. Novel 2-Carbonylbenzo[b]thiophene 1,1-Dioxide Derivatives as Potent Inhibitors of STAT3 Signaling Pathway. ACS Med Chem Lett. 2015;6:1010-4.
[19] Han K, Xu X, Xu Z, Chen G, Zeng Y, Zhang Z, Cao B, Kong Y, Tang X, Mao X*. SC06, a novel small molecule compound, displays preclinical activity against multiple myeloma by disrupting the mTOR signaling pathway. Sci Rep. 2015;5:12809.
[20] Juan J#, Cheng L*, Shi M#, Liu Z, Mao X*. Poly-(allylamine hydrochloride)-coated but not poly(acrylic acid)-coated upconversion nanoparticles induce autophagy and apoptosis in human blood cancer cells. J Mater Chem B, 2015;3:5769-5776.
[21] Zhu J, Hou T*, Mao X*. Discovery of selective phosphatidylinositol 3-kinase inhibitors to treat hematological malignancies. Drug Discovery Today. 2015; 20:988-94.
[22] Zhu J#, Wang M#, Yu Y, Qi H, Han K, Tang J, Zhang Z, Zeng Y, Cao B, Qiao C, Zhang H, Hou T*, Mao X*. A novel PI3K inhibitor PIK-C98 displays potent preclinical activity against multiple myeloma. Oncotarget.2015;6:185-95.