个人简历

2004年北京大学化学与分子工程学院获理学学士学位\r
2008年美国斯坦福大学(Stanford University)获得化学博士学位\r
2008年至2009年在斯坦福大学化学系以及医学院从事博士后研究\r
2009年6月加入苏州大学功能纳米与软物质研究院，被聘为教授，博士生导师

研究领域

"""""无机纳米材料与肿瘤诊疗创新技术\r
高分子与仿生纳米载体\r
纳米生物材料与肿瘤微环境调控\r
纳米放射医学\r
生物材料与免疫工程\r
生物材料与纳米医学的临床转化"

近期论文

Linfu Chen, Lin Zhang , Rui Zhao , Jingjing Shen, Yingyao Wang, Jiafei Zhu, Huapan Fang, Nanhui Liu, Cheng Wang, Ting Wei, Yu Chai, Maoyi Li, Chenghao Wu, Qian Chen*, Zhuang Liu*. “Oral delivery of anti-PD-L1 antibody for cancer immunotherapy against orthotopic colorectal tumors” Nano Today, 50, 101834 (2023)\r
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Fengyun Shen, Zijian Xiong, Yumin Wu, Rui Peng, Yue Wang, Lele Sun, Chunhai Fan, Zhuang Liu*. “Precise Epitope Organization with Self-adjuvant Framework Nucleic Acid for Efficient COVID-19 Peptide Vaccine Construction”, Angew. Chem. Int. Ed., DOI:10.1002/anie.202301147 (2023)\r
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Lele Sun*, Zhuang Liu*. “Precise regulation of intermembrane spacing with DNA nanojunctions for enhanced T-cell receptor triggering”, Science China Chemistry, DOI:10.1007/s11426-023-1571-9 (2023)\r
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Yu Hao, Minming Chen, Yumin Wu, Ziliang Dong, Yujie Zhu, Chunjie Wang, Quguang Li, Zhijuan Yang, Zhuang Liu*, Liangzhu Feng*. “CaCO3 based proton nanosponge to potentiate immune checkpoint blockade therapy by synergistically reversing tumor immunosuppression” Chemical Engineering Journal, 462, 142206 (2023)\r
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Huapan Fang, Yicheng Wu, Linfu Chen, Zhiqin Cao, Zheng Deng, Rui Zhao, Lin Zhang, Yang Yang*, Zhuang Liu*, and Qian Chen*. “Regulating the Obesity-Related Tumor Microenvironment to Improve Cancer Immunotherapy” ACS Nano, 17, 5, 4748-4763 (2023)\r
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Wenjun Zhu, Yu Chao, Qiutong Jin, Linfu Chen, Jingjing Shen, Jiafei Zhu, Yu Chai, Panhao Lu, Nailin Yang, Muchao Chen, Yang Yang*, Qian Chen*, and Zhuang Liu*. “Oral Delivery of Therapeutic Antibodies with a Transmucosal Polymeric Carrier”, ACS Nano, 17, 5, 4373-4386 (2023)\r
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Yu Chao, Ting Wei, Qiaofeng Li, Bo Liu, Yu Hao, Muchao Chen, Yuzhe Wu, Fanxin Song , Qian Chen*, Zhuang Liu*. “Metformin-containing hydrogel scaffold to augment CAR-T therapy against post-surgical solid tumors” Biomaterials, 295, 122052 (2023)\r
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Yu Chao , Zhuang Liu*. “Biomaterials tools to modulate the tumour microenvironment in immunotherapy” Nature Reviews Bioengineering, 1, 125-138 (2023)\r
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Jingjing Shen, Huiqin Gao, Linfu Chen, Yutong Jiang, Shu Li, Yu Chao, Nanhui Liu, Yufei Wang, Ting Wei, Yan Liu, Jipeng Li, Muchao Chen, Jiafei Zhu, Juan Liang, Xiaoyu Zhou, Xiaofeng*, Ping Gu*, Qian Chen*, Zhuang Liu*. “Eyedrop-based macromolecular ophthalmic drug delivery for ocular fundus disease treatment” Science Advances, 9, 4 (2023) \r
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Huapan Fang, Linfu Chen, Zheng Deng, Yunxuan Gao, Yang Yang, Qian Chen*, and Zhuang Liu*. “In Situ Polymerization of Zwitterions on Therapeutic Proteins to Enable Their Effective Oral Delivery” ACS Nano, 17, 2, 1128-1143 (2023)\r
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Zijian Xiong, Lele Sun*, He Yang, Zhisheng Xiao, Zheng Deng, Quguang Li,Chenya Wang, Fengyun Shen, and Zhuang Liu*. “Ni-Alginate Hydrogel Microspheres with Sustained Interleukin 2 Release to Boost Cytokine-Based Cancer Immunotherapy” Adv. Funct. Mater., 2211423 (2022)\r
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Zheng Deng , Jiawei Liu , Min Xi , Chunjie Wang , Huapan Fang , Xirui Wu , Cai Zhang , Guanting Sun, Yifan Zhang, Lin Shen , Minjiang Chen , Jiansong Ji * , Zhuang Liu *, Guangbao Yang *. “Biogenic platinum nanoparticles on bacterial fragments for enhanced radiotherapy to boost antitumor immunity” Nano Today, 47, 101656 (2022)\r
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Qiaofeng Li, Yu Chao*, Bo Liu, Zhisheng Xiao, Zhijuan Yang, Yuzhe Wu, Zhuang Liu *. “Disulfiram loaded calcium phosphate nanoparticles for enhanced cancer immunotherapy” Biomaterials, 291, 121880 (2022)\r
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Yuqi Yang, Jun Ge, Guangqiang Li, Huali Lei, Linfu Chen, Yuehan Gong, Xiaoyan Zhong, Li Wang, Yizhi Dai, Wei Tang, Jun Zou, Yuan Cheng, Zhuang Liu, Liang Cheng*. “Manganese-doping titanium disulfide cascade nanobioreactors for sequential gas-sonodynamic strategy with immune checkpoint blockade therapy of cancer” Nano Today, 46, 101585 (2022).\r
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Xiaoyuan Yang, Nailin Yang, Lei Zhang, Dongxu Zhao, Huali Lei, Shuning Cheng,Jun Ge, Xiaoming Ma*, Caifang Ni, Zhuang Liu, Liang Cheng*. “Eddy current thermal effect based on magnesium microrods for combined tumor therapy” Chemical Engineering Journal, 446, 137038 (2022)\r
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Guowang Cheng, Xueliang Liu, Yujing Liu, Yao Liu, Rui Ma, Jingshan Luo,Xinyi Zhou,, Zhenfeng Wu* , Zhuang Liu, Tongkai Chen* , and Yu Yang*. “Ultrasmall Coordination Polymers for Alleviating ROS-Mediated Inflammatory and Realizing Neuroprotection against Parkinson’s Disease” Research, 9781323 (2022)\r
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Yu Yang, Bo Liu, Yuan Liu, Jingqi Chen, Yujia Sun, Xiaoshu Pan, Jun Xu, Shujuan Xu, Zhuang Liu*,and Weihong Tan*. “DNA-Based MXFs to Enhance Radiotherapy and Stimulate Robust Antitumor Immune Responses” Nano Lett., 22, 7, 2826-2834 (2022)\r
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Linqian Hou, Fei Gong*, Zhihui Han, Yuanjie Wang, Yuqi Yang, Shuning Cheng, Nailin Yang, Zhuang Liu, Liang Cheng*. “HXV2O5 Nanocatalysts Combined with Ultrasound for Triple Amplification of Oxidative Stress to Enhance Cancer Catalytic Therapy” Angew Chem Lnt Ed, 39, e202208849 (2022)\r
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Fengyun Shen, Danlei Tao, Rui Peng, Yao He, Zhuang Liu, Jiansong Ji*, Liangzhu Feng*. “Immunogenic nanomedicine based on GSH-responsive nanoscale covalent organic polymers for chemo-sonodynamic therapy” Biomaterials, 283, 121428 (2022)\r
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Zhijuan Yang, Danlei Tao, Wenzhao Zhong, Zhuang Liu, Liangzhu Feng*, Meiwan Chen*. “Perfluorocarbon loaded fluorinated covalent organic polymers with effective sonosensitization and tumor hypoxia relief enable synergistic sonodynamic-immunotherapy” Biomaterials, 280, 121250 (2022)\r
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Linqian Hou, Fei Gong*, Bo Liu, Xiaoyuan Yang, Linfu Chen, Guangqiang Lie, Yuehan Gong, Chao Liang, Nailin Yang, Xian Shen*, Zhuang Liu, Liang Cheng*. “Orally administered titanium carbide nanosheets as anti-inflammatory therapy for colitis” Theranostics,12(8), 3834-3846 (2022)\r
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Yikai Han, Ziliang Dong, Chunjie Wang, Quguang Li, Yu Hao, Zhijuan Yang, Wenjun Zhu, Yunyun Zhang, Zhuang Liu*, Liangzhu Feng. “Ferrous ions doped calcium carbonate nanoparticles potentiate chemotherapy by inducing ferroptosis” Journal of Controlled Release, 348, 346-356 (2022).\r
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Ziliang Dong, Chunjie Wang, Yimou Gong, Yunyun Zhang, Qin Fan, Yu Hao, Quguang Li, Yumin Wu, Xiaoyan Zhong, Kai Yang, Liangzhu Feng*, and Zhuang Liu*. “Chemical Modulation of Glucose Metabolism with a Fluorinated CaCO3 Nanoregulator Can Potentiate Radiotherapy by Programming Antitumor Immunity” ACS Nano, 16, 9, 13884-13889 (2022)\r
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Zhisheng Xiao, Ting Wei, Ruiliang Ge*, Qiaofeng Li, Bo Liu, Zhaoxin Ji, Linfu Chen, Junjie Zhu, Jingjing Shen, Zhuang Liu, Yueye Huang*, Yang Yang*, Qian Chen*. “Microfluidic Production of Zwitterion Coating Microcapsules with Low Foreign Body Reactions for Improved Islet Transplantation” Small, 18, 29, 2202596 (2022)\r
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Jun Zhou, Maoyi Li, Qiufang Chen, Xinjie Li, Linfu Chen, Ziliang Dong, Wenjun Zhu, Yang Yang, Zhuang Liu* & Qian Chen*. “Programmable probiotics modulate inflammation and gut microbiota for inflammatory bowel disease treatment after effective oral delivery” Nat.Commun., 13, 3432 (2022)\r
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Yujie Zhu, Zhijuan Yang, Zijian Pan, Yu Hao, Chunjie Wang, Ziliang Dong, Quguang Li, Yikai Han, Longlong Tian, Liangzhu Feng*, Zhuang Liu*. “Metallo-alginate hydrogel can potentiate microwave tumor ablation for synergistic cancer treatment” Science Advances, 8, 31, 5285 (2022)\r
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Han Zhang, Kai Liu, Yimou Gong, Wenjun Zhu, Jiafei Zhu, Feng Pan, Yu Chao, Zhishen Xiao, Yanbin Liu, Xianwen Wang, Zhuang Liu, Yang Yang*, Qian Chen*. “Vitamin C supramolecular hydrogel for enhanced cancer immunotherapy” Biomaterials, 287, 121673 (2022)\r
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Huali Lei, Ji Hyeon Kim, Subin Son, Linfu Chen, Zifan Pei, Yuqi Yang, Zhuang Liu*, Liang Cheng*, and Jong Seung Kim*. “Immunosonodynamic Therapy Designed with Activatable Sonosensitizer and Immune Stimulant Imiquimod” ACS nano, 16, 7, 10979-10993 (2022)\r
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Minjiang Chen, Gaofeng Shu, Xiuling Lv, Xiaoling Xu, Chenying Lu, Enqi Qiao, Shiji Fang, Lin Shen, Nannan Zhang, Jun Wang, Chunmiao Chen, Jingjing Song, Zhuang Liu*, Yongzhong Du*, Jiansong Ji*. “HIF-2α-targeted interventional chemoembolization multifunctional microspheres for effective elimination of hepatocellular carcinoma” Biomaterials, 284, 121512 (2022)\r
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Fengyun Shen, Lele Sun*, Lihua Wang, Rui Peng*, Chunhai Fan, and Zhuang Liu*. “Framework Nucleic Acid Immune Adjuvant for Transdermal Delivery Based Chemo-immunotherapy for Malignant Melanoma Treatment” Nano Lett., 22, 11, 4509-4518 (2022) \r
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Nailin Yang, Fei Gong, Bo Liu, Yu Hao, Yu Chao, Huali Lei, Xiaoyuan Yang, Yuehan Gong, Xianwen Wang, Zhuang Liu* & Liang Cheng*. “Magnesium galvanic cells produce hydrogen and modulate the tumor microenvironment to inhibit cancer growth” Nat. Commun., 13, 2336 (2022) \r
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Lele Sun, Fengyun Shen, Zijian Xiong, He Yang, Ziliang Dong, Jian Xiang, Qingyang Gu, Qunsheng Ji, Chunhai Fan, and Zhuang Liu*. “DNA Engineered Lymphocyte-Based Homologous Targeting Artificial Antigen-Presenting Cells for Personalized Cancer Immunotherapy” J. Am. Chem. Soc., 144,17,7634-7645 (2022) \r
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Yu Hao, Lei Zhang, Ziliang Dong, Chunjie Wang, Yu Chao, Dongxu Zhao, Yujie Zhu, Zhijuan Yang, Nailin Yang, Yikai Han, Liangzhu Feng*, Zhuang Liu*. “Percutaneous implantation of ethanol fueled catalytic hydrogel suppresses tumor growth by triggering ferroptosis” Materials today, 55, 7-20 (2022) \r
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Zhouqi Meng, Yaojia Zhang, Xuanfang Zhou, Jiansong Ji*, Zhuang Liu*. “Nanovaccines with cell-derived components for cancer immunotherapy” Adv. Drug Deliv. Rev., 182, 114107 (2022)\r
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Hairong Wang, Yu Chao, He Zhao, Xiuxia Zhou, Fuyong Zhang, Zheng Zhang, Zhiheng Li, Jian Pan, Jian Wang*, Qian Chen*, and Zhuang Liu*. “Smart Nanomedicine to Enable Crossing Blood–Brain Barrier Delivery of Checkpoint Blockade Antibody for Immunotherapy of Glioma” ACS Nano, 16, 1, 664-674 (2022)\r
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Longlong Tian, Ming Shao, Yimou Gong, Yu Chao, Ting Wei, Kai Yang, Qian Chen* & Zhuang Liu*. “Albumin-binding lipid-aptamer conjugates for cancer immunoimaging and immunotherapy” Sci. China Chem., 65,574-583 (2021) \r
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Zhijuan Yang, Yujie Zhu, Ziliang Dong, Yu Hao, Chunjie Wang, Quguang Li, Yumin Wu, Liangzhu Feng*, Zhuang Liu*. “Engineering bioluminescent bacteria to boost photodynamic therapy and systemic anti-tumor immunity for synergistic cancer treatment”Biomaterials, 281, 121332 (2021) \r
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Fei Gong, Jiachen Xu, Bo Liu, NailinYang, Liang Cheng*, Peng Huang, Chunjie Wang, Qian Chen, Caifang Ni*, Zhuang Liu*. “Nanoscale CaH2 materials for synergistic hydrogen-immune cancer therapy” Chem, 8 (1) ,268-286 (2021)\r
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Chunjie Wang, Ziliang Dong, Yu Hao, Yujie Zhu, Jing Ni, Quguang Li, Bo Liu, Yikai Han, Zhijuan Yang, Jianmei Wan, Kai Yang, Zhuang Liu*, Liangzhu Feng*.”Coordination Polymer Coated CaCO3 Reinforces Radiotherapy by Reprogramming the Immunosuppressive Metabolic Microenvironment” Adv. Mater., 2106520 (2021) \r
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Yu Yang, Hao Wu, Bo Liu, Zhuang Liu*. “Tumor microenvironment-responsive dynamic inorganic nanoassemblies for cancer imaging and treatment” Adv. Drug Deliv. Rev., 179, 114004 (2021)\r
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Guangbao Yang*,Jiansong Ji*, Zhuang Liu*. “Multifunctional MnO2 nanoparticles for tumor microenvironment modulation and cancer therapy” Wiley Interdiscip Rev Nanomed Nanobiotechnol.,13 (6), e1720 (2021) \r
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Bo Liu, Yu Yang*, Yu Chao, Zhisheng Xiao, Jialu Xu, Chunjie Wang, Ziliang Dong, Linqian Hou, Qiaofeng Li, and Zhuang Liu*.”Equipping Cancer Cell Membrane Vesicles with Functional DNA as a Targeted Vaccine for Cancer Immunotherapy” Nano Lett., 21,22,9410-9418 (2021) \r
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Muchao Chen, Yanjun Tan, Jiaying Hu, Yanping Jiang, Zixian Wang, Zhuang Liu, Qian Chen*. “Injectable Immunotherapeutic Thermogel for Enhanced Immunotherapy Post Tumor Radiofrequency Ablation” Small, 2104773 (2021)\r
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Nailin Yang, Fei Gong, Yangkai Zhou, Yu Hao, Ziliang Dong, Huali Lei, Liping Zhong, Xiaoyuan Yang, Xianwen Wang, Yongxiang Zhao*, Zhuang Liu, Liang Cheng*.”A general in-situ reduction method to prepare core-shell liquid-metal/metal nanoparticles for photothermally enhanced catalytic cancer therapy” Biomaterials, 277, 121125 (2021)\r
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He Zhao, Xinjing Lv, Jie Huang, Shungen Huang, Huiting Zhou, Hairong Wang, Yunyun Xu, Jianghuai Wang, Jian Wang*, Zhuang Liu*. \