个人简历

2018.7至今：教授，苏州大学医学部药学院\r
2012.9 — 2018.7：特聘副教授，苏州大学医学部药学院\r
2009.5 — 2012.8：博士后研究助理，北卡罗来纳大学教堂山分校药学院\r
2009.1—2009.5；助理研究员，中科院上海有机所\r
2003.9— 2009.1：研究生，中科院上海有机所\r
1999.9— 2003.7：本科，厦门大学化学系

研究领域

""（1）表观遗传蛋白小分子调控剂的设计与合成\r
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（2）神经疾病和癌症的“靶向治疗”药物研发\r
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（3）有机合成新方法在药物研发中的应用"""主要从事药物设计与合成及有机合成新方法等领域的研究。"

近期论文

31) Qin, H.-T.; Xu, X.; Liu, F.* “Aerobic Oxidation of Alkynes into 1,2-Diketones via Organic Photoredox Catalysis” ChemCatChem 2017, DOI: 10.1002/cctc.201700061\r
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30) Qin, H.-T.; Wu, S.-W.; Liu, J.-L.; Liu, F.* “Photoredox-Catalysed Redox-Neutral Trifluoromethylation of Vinyl Azides for the Synthesis of a–Trifluoromethylated Ketones” Chem. Commun.2017, 53, 1696-1699.\r
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29) Qin, H.-T.; Li, H.-Q.;*Liu, F.* “Selective histone deacetylase small molecule inhibitors: recent progress and perspectives” Expert Opin. Ther. Pat.2017, DOI: 10.1080/13543776.2017.1276565\r
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28) Wu, S.-W.; Liu, F.* “Synthesis of α-Fluoroketones from Vinyl Azides and Mechanism Interrogation” Org. Lett.2016, 18, 3642-3645.\r
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27) Li, Z.-R.; Bao, X.-X.; Sun, J.; Shen, J.; Wu, D.-Q.; Liu, Y.-K.; Deng, Q.-H.*; Liu, F.* “Iron-catalyzed trifluoromethylation of vinylcyclopropanes: facile synthesis of CF3-containing dihydronaphthalene derivatives” Org. Chem. Front.2016,3, 934-938.\r
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26) Wu, S.-W.; Liu, J.-Li.; Liu, F.* “Metal-Free Microwave-Assisted Decarboxylative Elimination for the Synthesis of Olefins” Org. Lett. 2016,18, 1-3.\r
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25) Simon, J. M.; Parker, J. S.; Liu, F.; Rothbart, S. B.; Ait-Si-Ali, S.; Strahl, B. D.; Jin, J.; Davis, I. J.; Mosley, A. L.; Pattenden, S. G. “A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin”J. Biol. Chem.2015, 290(43):26088-26102. DOI: 10.1074/jbc.M115.654459. PMID: 26338712\r
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24) Zhang, Y.; Xu, L.; Zhang, Z.; Zheng, L.; Li, D.; Li, Y.; Liu, F.; Yu, K.; Hou, T.; Zhen, X. “Structure-Activity Relationships and Anti-inflammatory Activities of N-Carbamothioylformamide Analogues as MIF Tautomerase Inhibitors” J. Chem. Inf. Model.2015, 55, 1994-2004. DOI: 10.1021/acs.jcim.5b00445\r
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23) Shi, D.; Qin, H.; Zhu, C;* Liu, F.* “Selectfluor–Bu4NI-Mediated C(sp3)–H Oxidation in Aqueous Media: Synthesis of Δ2-Isoxazolines from Oximes” Eur.J. Org. Chem.2015, 5084-5088. DOI: 10.1002/ejoc.201500780\r
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22) Wang, L.; Xie, L.; Ramachandran, S.; Lee, Y.; Yan, Z.; Zhou, L.; Krajewski, K.; Liu, F.; Zhu, C.; Chen, David J.; Strahl, Brian D.; Jin, J.; Dokholyan, Nikolay V.; Chen, X. “Non-canonical Bromodomain within DNA-PKcs Promotes DNA Damage Response and Radioresistance through Recognizing an IR-Induced Acetyl-Lysine on H2AX” Chem. Biol.2015, 22, 7, 849-861. DOI: 10.1016/j.chembiol.2015.05.014. \r
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21) Zhang, Z.; Liu, F.* “CuX2-mediated oxybromination/aminochlorination of unsaturated amides: synthesis of iminolactones and lactams” Org. Biomol. Chem. 2015, 13, 6690-6693. DOI: 10.1039/c5ob00520e\r
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20) Dong, K.; Qin, H.; Liu, F.*; Zhu, C.* “Oxime-Mediated Oxychlorination and Oxybromination of Unactivated Olefins” Eur.J. Org. Chem.2015, 1419-1422. DOI: 10.1002/ejoc.201403538\r
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19) Liu, C.; Yu, Y.; Liu, F.; Wei, X.; Wrobel, J. A.; Gunawardena, H. P.; Zhou, L.; Jin, J.; Chen, X. “A chromatin activity-based chemoproteomic approach reveals a transcriptional repressome for gene-specific silencing” Nat. Commun.2014, 5:5733. DOI: 10.1038/ncomms6733.\r
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18) Dong, K.; Qin, H.; Bao, X.; Liu, F.*; Zhu, C.* “Oxime-mediated facile access to 5-methylisoxazoles and applications in the synthesis of valdecoxib and oxacillin” Org. Lett. 2014,16, 5266-5268.\r
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17) Sundriyal, S.; Malmquist, N. A.; Caron, J.; Blundell, S.; Liu, F.; Chen, X.; Srimongkolpithak, N.; Jin, J.; Charman, S. A.; Scherf, A.; Fuchter, M. J. “Development of Diaminoquinazoline Histone Lysine Methyltransferase Inhibitors as Potent Blood-Stage Antimalarial Compounds” ChemMedChem, 2014, 9, 2360-2373.\r
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16) Lehnertz, B.; Pabst, C.; Su, L.; Miller, M.; Liu, F.;Yi, L.; Zhang, R., Krosl, J., Yung, E., Kirschner, J., Rosten, P., Underhill, T. M., Jin, J., Hébert, J., Sauvageau, G., Humphries, R. K., Rossi, F. M. “The methyltransferase G9a regulates HoxA9-dependent transcription in AML” Genes Dev.2014, 28, 317-327.\r
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15) Konze, K. D.; Pattenden, S. G.; Liu, F.; Barsyte-Lovejoy, D.; Li, F.; Simon, J. M.; Davis, I. J.; Vedadi, M.; Jin, J. “A chemical tool for in vitro and in vivo precipitation of lysine methyltransferase G9a” ChemMedChem, 2014, 9, 549-553.\r
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14) Liu, F.*; Li. C. “ Total synthesis of (S)-14-azacamptothecin”, Org. Biomol. Chem.2014, 12, 637-642.\r
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13) Liu, F.; Barsyte-Lovejoy, D.; Li, F.; Xiong, Y.; Korboukh, V.; Huang, X. P.; Allali-Hassani, A.; Janzen, W. P.; Roth, B. L.; Frye, S. V.; Arrowsmith, C. H.; Brown, P. J.; Vedadi, M.; Jin, J. “Discovery of an in vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP” J. Med. Chem. 2013, 56, 8931-8942.\r
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12) Konze, K. D.; Ma, A.; Li, F.; Barsyte-Lovejoy, D.; Parton, T.; MacNevin, C. J.; Liu, F.; Gao, C.; Huang, X. P.; Kuznetsova, E.; Rougie, M.; Jiang, A.; Pattenden, S. G.; Norris, J. L.; James, L. I.; Roth, B. L.; Brown, P. J.; Frye, S. V.; Arrowsmith, C. H.; Hahn, K. M.; Wang, G. G.; Vedadi, M.; Jin, J. “An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1”, ACS Chemical Biology, 2013, 8, 1324-1334.