个人简历

学历背景：
2004.9－2008.9 南京大学生命科学院,硕博连读,理学博士
2000.9－2004.7 吉林大学生物与农业工程学院,工学学士
工作经历：
2014.3－2015.5 美国新墨西哥大学化学与化学生物系，访问学者
2011.3－ 今 苏州大学医学部药学院，副教授
2008.9 -2010.12 南京大学化学化工学院，博士后

研究领域

（1）基于多靶点的急性痛风性关节炎药物的设计与合成
（2）靶向抗癌先导药物的设计与合成
（3）计算机辅助药物设计研究

近期论文

1. Huanqiu Li, Guihua Zeng, Yongyi Wei, Weimin Xuan, Roushu Zhang, Larisa E. Breden, Wei Wang, Fu-Sen Liang. Engineering Iron Responses in Mammalian Cells by Signal-Induced Protein. ACS Synthetic Biology, 2017 , 6 (6) :921-927.
2. Qinghua Hu, Mengze Zhou, Haoran Zhu, Guo Lu, Dongsen Zheng, Huanqiu Li*, Kun Hao, (E)-2-(4-bromophenyl)-1-(2, 4-dihydroxyphenyl)ethanone oxime is a potential therapeutic agent for treatment of hyperuricemia through its dual inhibitory effects on XOD and URAT1. Biomed Pharmacother2017, 86:88-94.
3. Gui-Zhen Ao, Meng-Ze Zhou, Yu-Yao Li, Si-Ning Li, Hua-Nian Wang, Qian-Wen Wan, Huan-Qiu Li*, Qing-Hua Hu*, Discovery of novel curcumin derivatives targeting xanthine oxidase and urate transporter 1 as anti-hyperuricemic agents. Bioorg Med Chem2017, 25:166-174.
4. Qin, H. T.; Li, H. Q.*; Liu, F*. Selective histone deacetylase small molecule inhibitors: recent progress and perspectives，Expert. Opin. Ther. Patents., 2017, 27 (5) :621.
5. Weimin Xuan, Rong Pan, Yongyi Wei, Yanting Cao, Huanqiu Li, Fusen Liang, Kejian Liu, Wei Wang. Reaction-Based “Off–On” Fluorescent Probe Enabling Detection of Endogenous Labile Fe2+ and Imaging of Zn2+-induced Fe2+ Flux in Living Cells and Elevated Fe2+ in Ischemic Stroke.Bioconjugate Chem2016, 27 (2):302-308.
6. Li, S. N.; Xu, Y. Y.; Gao, J. Y.; Yin, H. R.; Zhang, S. L.; Li, H. Q. * Combination of 4-anilinoquinazoline and rhodanine as novel epidermal growth factor receptor tyrosine kinase inhibitor,Bioorg Med Chem, 2015, 23:3221-3227.
7. Li, S. N.; Li, H. Q. * Epidermal Growth Factor Receptor (EGFR) inhibitors: a patent review (2010 - present), Expert. Opin. Ther. Patents. 2014, 24(3): 309-321.
8. Song, H.; Ao, G. Z.; Li, H. Q. * Novel FabH inhibitors: a updated article literature review(July 2012 to June 2013), Expert. Opin. Ther. Patents. 2014, 24(1): 19-27.
9. Yun-Yun Xu, Yi Cao, Hailkuo Ma, Huan-Qiu Li* Gui-zhen Ao， Design, synthesis and molecular docking of alpha & beta-unsaturated cyclohexanone analogous of curcumin as potent EGFR inhibitors with antiproliferativeactivity.Bioorg Med Chem2013, 21,388-394.
10. Xu,Y. Y.; Li, S. N.; Yu, G. J.; Hu, Q. H.; Li, H. Q. * Discovery of novel 4-anilinoquinazoline derivatives as potent inhibitors of epidermal growth factor receptor with antitumor activity, Bioorg Med Chem, 2013, 21:6084-6091.
11. Haikuo Ma, Huan-Qiu Li, Xiaohu Zhang*.Cyclopamine, a Naturally Occuring Alkaloid, and Its Analogues May Find Wide Applications in Cancer Therapy. Curr Top Med Chem2013, 13:2208-2215.
12. Huan-Qiu Li, Jing Yang, Shu-Hua Ma, Chun-Hua Qiao. Structure-Based Design of Rhodanine-based Acylsulfonamide Derivatives as Antagonists of the Anti-apoptotic Bcl-2 Protein. Bioorg Med Chem2012, 20:4194-4200.
13. Huan-Qiu Li*, Dong- Dong Li, Xiang Lu, Hai-Liang Zhu.Design and synthesis of 4,6-substituted-(diaphenylamino)quinazolines as potent EGFR inhibitors with antitumor activity.Bioorg Med Chem2012, 20:317-323.
14. Huan-Qiu Li*, Chun-Hua Qiao*. The Mechanisms of Anticancer Agents by Genistein and Synthetic Derivatives of Isoflavone. Mini-Rev Med Chem2012, 12:350-362.