个人简历

学历背景
2005.9-2009.7 中国科学技术大学化学系，本科
2009.9-2015.1 清华大学化学系，博士
工作经历
2015.1-2017.1 清华大学生命学院，博士后
2017.2-2019.3 中国科学技术大学生命学院，副研究员
2019.3- 至今 苏州大学医学部药学院药理系，副教授

研究领域

翻译后修饰蛋白质的化学合成和结构功能分析
设计和合成蛋白质探针并应用于翻译后修饰相关的药物发现和靶标鉴定
药物多肽的合成和结构改造

近期论文

[1] Chu G-C,# Pan M,# Li J,# Liu S,# Zuo C, Tong Z-B, Bai J-S, Gong Q, Ai H, Fan J, Shi J, Deng H, Tian C,* Li Y-M,* and Liu L*. Cysteine-Aminoethylation-Assisted Chemical Ubiquitination of Recombinant Histones. J. Am. Chem. Soc. 2019; 141: 3654-3663. (#Co-first author)
[2] Ai H, Guo Y, Sun D, Liu S, Qi Y, Guo J, Qu Q, Gong Q, Zhao S,* Li J,* Liu L.* Examination of the deubiquitination site-selectivity of USP51 using chemically synthesized ubiquitinated histones. ChemBioChem 2019; 20: 221-229.
[3] Li J-B,# Yun-Kun Qi Y-K,# Qiao-Qiao He Q-Q, Hua-Song Ai H-S, San-Ling Liu S-L, Jia-Xing Wang J-X, Ji-Sheng Zheng J-S, Lei Liu L, Changlin Tian C. Chemically synthesized histone H2A Lys13 di-ubiquitination promotes binding of 53BP1 to nucleosomes. Cell Res.2018; 28: 257-260.
[4] Li J-B,# Tang S,# Zheng J-S, Tian C-L, Liu L. Removable Backbone Modification Method for the Chemical Synthesis of Membrane Proteins. Acc. Chem. Res. 2017; 50: 1143-1153.
[5] Qi Y-K, He Q-Q, Ai H-S, Guo J, Li J-B.* The convergent chemical synthesis of histone H3 protein for site-specific acetylation at Lys56 and ubiquitination at Lys122. Chem. Commun. 2017; 53: 4148-4152.