个人简历

教育背景\r
本科& 硕士(9/2002 – 7/2008)北京科技大学应用学院，应用化学/分析化学 导师：杨运旭教授\r
博士 (9/2008 – 7/2011)中国医学科学院北京协和医学院医药生物技术研究所, 微生物与生化药学导师：李卓荣研究员\r
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工作经历\r
12/2014-至今：Research Scientist, 佐治亚州立大学化学系，导师：王炳和教授\r
12/2013-12/2014: 博士后, 佐治亚州立大学,化学系, 导师：王炳和教授\r
9/2011-12/2013: 助理研究员, 协和医学院医药生物技术研究所

研究领域

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近期论文

Yueqing Zheng#, Xingyue Ji#,Bingchen Yu, Kaili Ji, Gallo, D.; Csizmadia, E.; Mengyuan Zhu, Roy Choudhury, M.; De La Cruz, L.; Chittavong, V.; Zhixiang Pan, Zhengnan Yuan, Otterbein, L. E.; Binghe Wang*. Enrichment-triggered Prodrug Activation Demonstrated through Mitochondria-targeted Delivery of Doxorubicin and Carbon Monoxide. Nat. Chem. 2018, 10, 787-794. (# 并列一作)\r
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Xingyue Ji and Binghe Wang. Strategies toward Organic Carbon Monoxide Prodrugs. Acc. Chem. Res. 2018, 51 (6), 1377–1385.\r
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Xingyue Ji, Cheng Zhou, Kaili Ji, Robert E. Aghoghovbia, Zhixiang Pan, Vayou Chittavong, Bowen Ke, Binghe Wang. Click and Release: A Chemical Strategy toward Developing Gasotransmitter Prodrugs by Using an Intramolecular Diels–Alder Reaction. Angew. Chem. Int. Ed. 2016, 55(51):15846-15851. (X-Mol 亮点报道).\r
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Xingyue Ji, Eman M. El-labbad, Kaili Ji, Deena S. Lasheen, Rabah A.T. Serya, Khaled A. Abouzid, and Binghe Wang. Click and Release: SO2 Prodrugs with Tunable Release Rates. Org. Lett. 2017, 19 (4): 818–821. (X-Mol 亮点报道).\r
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Zhixiang Pan, Jun Zhang, Kaili Ji, Vayou Chittavong, Xingyue Ji*, and Binghe Wang*.Organic CO Prodrugs Activated by Endogenous ROS. Org. Lett. 2018, 20, 8-11. (X-Mol 亮点报道).\r
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Ladie Kimberly C. De La Cruz, Stéphane L. Benoit, Zhixiang Pan, Bingchen Yu, Robert J. Maier, Xingyue Ji*and Binghe Wang*. Click, release, and fluoresce: a chemical strategy for a cascade prodrug system for co-delivery of carbon monoxide, a drug payload and a fluorescent reporter. Org. Lett. 2018, 20 (4), pp 897–900. (Highlighted in 13 international press: https://acs.altmetric.com/details/32433850/news).\r
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Xingyue Ji, Jinhua Chen, Guanghui Zheng, Menghao Huang, Lei Zhang, Hong Yi, Jie Jin, Jiandong Jiang, Zonggen Peng, and Zhuorong Li. Design and Synthesis of Cajanine Analogues against Hepatitis C Virus through Down-Regulating Host Chondroitin Sulfate N-Acetylgalactosaminyltransferase 1. J. Med. Chem., 2016, 59 (22), 10268–10284. (BioCentury Innovations 及X-Mol 亮点报道).\r
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Xingyue Ji, Ladie Kimberly C. De La Cruz, Zhixiang Pan, Vayou Chittavong and Binghe Wang*. pH-Sensitive metal-free carbon monoxide prodrugs with tunable and predictable release rates. Chem. Commun. 2017, 53, 9628-9631.\r
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Xingyue Ji, Kaili Ji, Vayou Chittavong, Bingchen Yu, Zhixiang Pan and Binghe Wang.An esterase-activated click and release approach to metal-free CO-prodrugs. Chem. Commun., 2017, 53, 8296-8299.\r
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Wenyi Wang, Xingyue Ji,* Zhenming Du and Binghe Wang*. Sulfur dioxide prodrugs: triggered release of SO2 via a click reaction. Chem. Commun., 2017, 53(8): 1370-1373 (内封面故事).\r
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Zhixiang Pan, Vayou Chittavong, Wei Li, Jun Zhang, Kaili Ji, Mengyuan Zhu, Xingyue Ji,* and Binghe Wang*. Organic CO-prodrugs: Structure CO-release rate relationship Studies. Chem. Eur. J. 2017, 23, 9838-9845.\r
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Xingyue Ji, Kaili Ji, Vayou Chittavong, Robert E. Aghoghovbia, Mengyuan Zhu, and Binghe Wang.Click and Fluoresce: A Bioorthogonally Activated Smart Probe for Wash-Free Fluorescent Labeling of Biomolecules.J. Org. Chem., 2017, 82(3): 1471–1476.\r
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Guang-hui Zheng, Jia-jia Shen, Hong Yi, Si-tu Xue, Zhen Wang, Xing-yue Ji*, and Zhuo-rong Li*. Design, synthesis and in vitro and in vivo antitumor activity of 3-benzylideneindolin-2-one derivatives, a novel class of small-molecule inhibitors of the MDM2-p53 interaction.Eur. J. Med. Chem.2014, 81: 277-88.\r
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Xing-yue Ji, Si-tu Xue, Yue-chen Zhan, Jia-jia Shen, Lin-tao Wu, Jie Jin, Zhen Wang, Zhuo-rong Li. Design, synthesis and antiproliferative activity of a novel class of indole-2-carboxylate derivatives. Eur. J. Med. Chem. 2014, 83: 409–418.\r
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Xingyue Ji, Krishna Damera, Yue-qin Zheng, Bing-chen Yu, Leo E. Otterbein, Bing-he Wang.Toward Carbon Monoxide–Based Therapeutics: Critical Drug Delivery and Developability Issues. J. Pharm. Sci. 2016, 105(2):406-16. (IF: 2.713, Featured article.)\r
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Xing-Yue Ji, Hui-Qiang Wang, Lan-Hu Hao, Wei-Ying He, Rong-Mei Gao, Yan-Ping Li, Yu-Huan Li, Jian-Dong Jiang and Zhuo-Rong Li.Synthesis and Antiviral Activity of N-Phenylbenzamide Derivatives, a Novel Class of Enterovirus 71 Inhibitors. Molecules. 2013, 18(3): 3630-3640.\r
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Xing-yue Ji, Zhao-jin Zhong, Si-tu Xue, Shuai Meng, Wei-ying He, Rong-mei Gao, Yu-huan Li* and Zhuo-rong Li*. Synthesis and antiviral activities of synthetic glutarimide derivatives. Chem. Pharm. Bull.2010, 58 (11): 1436-1441.\r
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Suresh Thareja, Mengyuan Zhu, Xingyue Ji* and Binghe Wang*. Boron-based small molecules in disease detection and treatment (2013–2016). Heterocycl. Comm. 2017, DOI: 10.1515/hc-2017-0086.\r
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Xingyue Ji, and Binghe Wang. Toward carbon monoxide based therapeutics: carbon monoxide in a pill. Pharm Pat Anal. 2017, 6, 171-177\r
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Xingyue Ji, Si-tu Xue, Zong-ying Liu, Guang-hui Zheng, and Zhuo-rong Li*. Total synthesis of cajanine and its antiproliferative activity against human hepatoma cells. Acta. Pharm. Sin.B. 2011, 1(2): 93-99.