个人简历

焦旸，女，2007年8月至今在苏州大学医学部放射医学与防护学院工作，现为辐射遗传学教研室教授。2001年毕业于东南大学临床医学专业，2007年于苏州大学获医学博士学位，2016年进入苏州大学放射医学博士后流动站。分别于2005至2007年赴美国乔治城大学，2015至2016年赴美国俄克拉荷马大学健康科学中心交流访问。主要研究方向为：（1）放射性损伤的分子机制研究：从长链非编码RNA这个新的角度揭示放射性肺损伤的分子机理。（2）肿瘤放射敏感性的分子调控机理：从肿瘤微环境的角度阐释异常脂代谢产物对肿瘤放疗敏感性的影响及分子机制。至今作为项目负责人主持国家自然科学基金项目2项、国家博士后基金1项、江苏省博士后基金1项、教育部博士点基金新教师基金1项；发表SCI论文17篇，其中一区1篇，二区5篇。获授权实用新型专利2 项，申请发明专利一项；主编专著一部；相关研究成果获2 0 1 2 年山东医学科技奖（市厅级，排名2 / 6 ），苏州市科技进步二等奖（参与），和中国核能行业协会科学技术二等奖（参与）。

研究领域

（1）放射性损伤的分子机制研究：从长链非编码RNA这个新的角度揭示放射性肺损伤的分子机理。（2）肿瘤放射敏感性的分子调控机理：从肿瘤微环境的角度阐释异常脂代谢产物对肿瘤放疗敏感性的影响及分子机制。

近期论文

Jiao Y, Watts T, Xue J, Hannafon B, Ding WQ, Sorafenib and docosahexaenoic acid act in synergy to suppress cancer cell viability: a role of heme oxygenase 1, BMC Cancer. 2018 Oct 26;18(1):1042. doi: 10.1186/s12885-018-4946-9.
Nie J(#) ，Zhang J(#) ，Wang L，Lu L，Yuan Q，An F，Zhang S(*)，Jiao Y(*)，Adipocytes promote cholangiocarcinoma metastasis through fatty acid binding protein 4，J Exp Clin Cancer Res，2017，13;36(1):183.
Yu C(#)，Jiao Y(#)，Xue J(#)，Zhang Q，Yang H，Xing L，Chen G，Wu J，Zhang S(*)，Cao J(*)，Metformin Sensitizes Non-small Cell Lung Cancer Cells to an Epigallocatechin-3-Gallate (EGCG) Treatment by Suppressing the Nrf2/HO-1 Signaling Pathway，Int J Biol Sci，2017，27;13(12):1560-1569.
Jiao Y, Hannafon BN, Zhang RR, Fung KM, Ding WQ. Docosahexaenoic acid and disulfiram act in concert to kill cancer cells: a mutual enhancement of their anticancer actions.Oncotarget. 2017, 14;8(11):17908-17920.
Jiao Y, Hannafon BN, Ding WQ. Disulfiram's anticancer activity: evidences and mechanisms. Anticancer Agents Med Chem. 2016;16(11):1378-1384
Lu L, Zhou J, Zhang J, Che J, Jiao Y*, Zhang Y*. Prevention and Therapeutic Effects and Mechanisms of Tanshinone IIA Sodium Sulfonate on Acute Liver Injury Mice Model. Evid Based Complement Alternat Med. 2016;2016:4097398. doi: 10.1155/2016/4097398.
Jiao Y, Zhang J, Lu L, Xu J, Qin L.The Fto Gene Regulates the Proliferation and Differentiation of Pre-Adipocytes in Vitro. Nutrients. 2016;8(2):102.
Nie J, Peng C, Pei W, Zhu W, Zhang S, Cao H, Qi X, Tong J, Jiao Y*. A novel role of long non-coding RNAs in response to X-ray irradiation. Toxicol In Vitro. 2015;30(1 Pt B):536-544.
Jiao Y, Liu C, Cui FM, Xu JY, Tong J, Qi XF, Wang LL, Zhu W.Long intergenic non-coding RNA induced by X-ray irradiation regulates DNA damage response signaling in the human bronchial epithelial BEAS-2B cell line. Oncol Lett. 2015;9(1):169-176.
Fan S, Meng Q, Xu J, Jiao Y, Zhao L, Zhang X, Sarkar FH, Brown ML, Dritschilo A, Rosen EM. DIM (3,3'-diindolylmethane) confers protection against ionizing radiation by a unique mechanism. Proc Natl Acad Sci U S A. 2013 12;110(46):18650-5.
Yang Y, Dong J, Sun K, Zhao L, Zhao F, Wang L, Jiao Y*. Obesity and incidence of lung cancer: a meta-analysis. Int J Cancer. 2013;132(5):1162-9.
Sun KK, Zhong N, Yang Y, Zhao Lin, Jiao Y*. Enhanced radiosensitivity of NSCLC cells by transducer of erbB2.1 (TOB1) through modulation of the MAPK/ERK pathway. Oncology Reports. 2013; 29: 2385-2391.
Che J, Lu Y, Feng C, Dong A, Jiao Y*. Overexpression of TOB1 confers radioprotection to bronchial epithelial cells through the MAPK/ERK pathway. Oncology Reports. 2013;30: 637-642.
Jiao Y, Wang HC, Fan SJ. Growth suppression and radiosensitivity increase by HMGB1 in breast cancer. Acta Pharmacol Sin. 2007;28(12):1957-67.
Jiao Y, Ge CM, Meng QH, Cao JP, Tong J, Fan SJ.Adenovirus-mediated expression of Tob1 sensitizes breast cancer cells to ionizing radiation. Acta Pharmacol Sin. 2007;28(10):1628-36.