个人简历

学历背景
1985.9－1990.7 上海医科大学（现复旦大学）药物化学本科，B. S.
1992.9－1995.7 中国辐射防护研究院放射医学硕士生，M.S.
1999.9－2002.6 中国药科科大学药物化学学博士生, Ph. D.
工作经历
1990.7－2002.11 中国辐射防护研究院，实习研究员、助理研究员
2002.7－至今苏州大学，副教授、副研究员、硕导

研究领域

1、新型治疗缺血性脑卒中药物设计、合成和活性研究
2、新型抗炎药的设计、合成和活性研究

近期论文

1. Fang J, Wang ZK, Wu SW, Shen WG, Ao GZ, Liu F. Photoredox-catalysed chloro-, bromo- and trifluoromethylthio-trifluoromethylation of unactivated alkenes with sodium triflinate. Chem Commun, 2017, 53(54): 7638-7641
2. Li W, Cao Y, Xu J, Wang Y, Li W, Wang Q, Hu Z, Hao Y, Hu L, Sun Y, Xu G, Ao G. YAP transcriptionally regulates COX-2 expression and GCCSysm-4 (G-4), a dual YAP/COX-2 inhibitor, overcomes drug resistance in colorectal cancer. J Exp Clin Cancer Res. 2017, 36(1):144
3. Zhang M, Wu X, Xu Y, He M, Yang J, Li J, Li Y, Ao G, Cheng J, Jia J. The cystathionine β-synthase/hydrogen sulfide pathway contributes to microglia-mediated neuroinflam- mation following cerebral ischemia. Brain Behav Immun. 2017, 66: 332-346.
4. Fang J, Shen WG, Ao GZ*, Liu F*.Transition-metal-free radical fluoroalkylation of iso- cyanides for the synthesis of tri-/di-/monofluoromethylated phenanthridines. Org Chem Front, 2017, 4: 2049-2453.
5. Ao GZ, Zhou MZ, Li YY, Li SN, Wang HN, Wan QW, Li HQ, Hu QH. Discovery of novel curcumin derivatives targeting xanthine oxidase and urate transporter 1 as anti-hyperuricemic agents. Bioorg Med Chem. 2017, 25(1): 166-174.
6. Li YY, Fang J, Ao GZ*. Cathepsin B and L inhibitors: a patent review (2010 - present). Expert Opin Ther Pat. 2016(6), 23:1-14.
7. Sun Y, Zhang Y, Li Y, Cheng J, Chen S, Xiao Y, Ao G*. Synthesis and biological evaluation of novel hydrogen sulfide releasing nicotinic acid derivatives. Bioorg Med Chem. 2016, 24(21):5368–5373.
8. Song H, Sun Y, Xu G, Hou B, Ao G*. Synthesis and biological evaluation of novel hydrogen sulfide releasing glycyrrhetic acid derivatives. J Enzyme Inhib Med Chem. 2016, 31(6): 1457-63.
9. Gu WW, Lu SQ, Ni Y, Liu ZH, Zhou XY, Zhu YM, Luo Y, Li X, Li LS, Sun WZ, Zhang HL, Ao GZ*. 2-(3′,5′-Dimethoxybenzylidene) cyclopentanone, a novel synthetic small-molecule compound, provides neuroprotective effects against ischemic stroke [J]. Neuroscience. 2016, 316 : 26–40.
10. Xu G, Wang J, Wu F, Wang N, Zhou W, Wang Q, Pan W, Ao G, Yang J. YAP and 14-3-3γ are involved in HS-OA-induced growth inhibition of hepatocellular carcinoma cells: A novel mechanism for hydrogen sulfide releasing oleanolic acid.Onco target, 2016,7(32): 52150- 52165.
11. Liu SH, Hu Y, Qian PF, Hu YW, Ao GZ*, Chen SH, Zhang SL*, Zhang YN. An efficient cascade approach to dibenzoxazepinones via nucleophilic aromatic substitution and Smiles rearrangement [J]. Tetrahedron Letters, 2015, 56 (17): 2211–2213.
12. Xie H, Xu Q, Jia J, Ao G, Sun Y, Hu L, Alkayed NJ, Wang C, Cheng J. Hydrogen sulfide protects against myocardial ischemia and reperfusion injury by activating AMP-activated protein kinase to restore autophagic flux [J]. Biochem Biophys Res Commun. 2015, 458(3): 632 – 638.
13. Wang Y, Jia J, Ao G#, Hu L, Liu H, Xiao Y, Du H, Alkayed NJ, Liu CF, Cheng J. Hydrogen sulfide protects blood-brain barrier integrity following cerebral ischemia. J Neurochem. 2014, 129(5): 827-838..（#并列第一作者）
14. Zhou X, Cao Y, Ao G, Hu L, Liu H, Wu J, Wang X, Jin M, Zheng S, Zhen X, Alkayed NJ, Jia J, Cheng J. CaMKKβ-dependent activation of AMP-activated protein kinase is critical to suppressive effects of hydrogen sulfide on neuroinflammation. Antioxid Redox Signal. 2014 Mar 13.
15. Gui-Zhen Ao, Xiao-Jing Chu, Yuan-Yuan Ji, Jian-Wen Wang. Antioxidant Properties and PC12 Cell Protective Effects of a Novel Curcumin Analogue (2E, 6E)-2,6-Bis (3,5-di - methoxy benzylidene) cyclohexanone (MCH) [J]. Int J Mol Sci, 2014, 15, 3970 -3988.
16. Feng J, He X, Zhou S, Peng F, Liu J, Hao L, Li H,Ao G, Yang S. Preparative separation of crocins and geniposide simultaneously from gardenia fruits using macroporous resin and reversed-phase chromatography[J].J Sep Sci, 2014, 37, 314- 322.
17. Cheng J, Du YF, Xiao ZY, Pan LL, Li W, Huan L, Gong ZN, Wei SH, Huang SQ, Xun W, Zhang Y, Chang LL, Xie MY, Ao GZ, et al. Growth inhibitory effect of KYKZL-1 on Hep G2 cells via inhibition of AA metabolites and caspase-3 pathway and cell cycle arrest[J].Toxicol Appl Pharm, 2014, 274(1): 96-106.
18. Song H,Ao GZ*,Li HQ. Novel FabH inhibitors: a updated article literature review (July 2012 to June 2013) [J].Expert Opin Ther Pat,2014, 24(1): 19-27.
19. Wei-wei GU#, Gui-zhen AO#, Yong-ming ZHU, Shi-chang SUN, Qiang ZHOU, Jia-hong FAN, Katunuma NOBUHIKO, Kazumi ISHIDOH, Hui-ling ZHANG, Xiu-mei GAO. Autophagy and cathepsin L are involved in the antinociceptive effect of DMBC in a mouse acetic acid-writhing model [J]. Acta Pharmacol Sin, 2013, 34(8):1007-12.
20. Jia Jia, Yunqi Xiao, Wei Wang, Lina Qing, Yinxiu Xu, Heng Song, Xuechu Zhen, Guizhen Ao*, Nabil J Alkayed, Jian Cheng*. Differential mechanisms underlying neuroprotection of hydrogen sulfide donors against oxidative stress [J]. Neurochem Int, 2013, 62, 1072-1078.