个人简历

出生日期：1977年10月。
食品科学与工程，管理学双硕士，食品质量与安全专业博士；副教授，硕士研究生导师。
深圳大学公共卫生学院副院长，深圳市天然新型保健品重点实验室副主任，深圳市过敏反应与免疫学研究所研究员，深圳市海外高层次人才，广东省营养学会理事。
2003年-至今 深圳大学工作；2016-2017年 美国康奈尔大学访问学者。
主要研究领域：食品安全管理，食物蛋白质致敏性、营养特性及功能特性，食物过敏反应及过敏蛋白原检测。重点研究蛋白质与小分子相互作用，研究两者共价与非共价相互作用在调控蛋白质功能特性和消化特性的作用机理，并首次将两者的共价相互作用应用于调控食物过敏原蛋白的致敏性。主持及参与国家、省、市等各类等科技项目近20项，发表论文80多篇，以第一作者或通讯作者在Trends in Food Science & Teleology，Journal of Agriculture & Food Chemistry，Food Chemistry等国际权威期刊上发表SCI论文近30篇，申请专利8项。
主要承担食品营养与食品安全方面的课程教学。

研究领域

主要研究领域：食品安全管理，食物蛋白质致敏性、营养特性及功能特性，食物过敏反应及过敏蛋白原检测

近期论文

Wu XL*, Lu YQ, Xu HX, Lv MY, Hu DS, He ZD, Liu LZ, Wang ZM ,Feng Y. Challenges to Improve the Safety of Dairy Products in China. Trends in Food Science & Technology, 2018, 76: 6-14. （TOP 期刊）
Xu HX, Zhang TT, Lu YQ, Lin X, Hu XP, Liu LZ, He ZD, Wu XL*. Effect of chlorogenic acid covalent conjugation on the allergenicity, digestibility and functional properties of whey protein. Food Chemistry, 2019, 298: 125024.（TOP 期刊）
He WY，Xu HX，Lu YQ，Zhang TT，Li SM，Lin X，Xu BQ，Wu XL*. Function, digestibility and allergenicity assessment of ovalbumin–EGCG conjugates. Journal of Functional Food，2019, 61：103490.
Xu HX, Lu YQ, Zhang TT, Liu K, Liu LZ, He ZD, Xu BQ, Wu XL*. Characterization of binding interactions of anthraquinones and bovine β-lactoglobulin. Food Chemistry, 2019, 281(30): 28-35.（TOP 期刊）
Lu YQ, Li SM, Xu HX, Zhang TT, Lin X, Wu XL*. Effect of covalent interaction with chlorogenic acid on the allergenic capacity of ovalbumin. Journal of Agriculture and Food Chemistry, 2018, 66 (37), 9794–9800.（TOP 期刊）
Wu XL*, Lu YQ, Xu HX, Lin DX, He ZD, Wu HQ, Liu LZ, Wang ZM. Reducing the allergenic capacity of β-lactoglobulin by covalent conjugation with dietary polyphenols. Food chemistry, 2018, Auguest, 256, 427-434.（TOP 期刊）
Wu XL*, Feng Y, Lu YQ, Li Y, Fan L, Liu LZ, Zhendan He*.Effect of phenolic hydroxyl groups on inhibitory activities of phenylpropanoid glycosides against lipase. Journal of Functional Foods. 2017,November,38, 510-518.
Feng Y, Lv MY, Lu YQ, Liu K, Liu LZ, He ZD, Wu KM, Wang XR, Zhang BS, Wu XL*. Characterization of binding interactions between selected phenylpropanoid glycosides and trypsin. Food Chemistry, 2018, 243: 118-124. （TOP 期刊）
Wu XL*, He WT, Li Y , Zhang HP, Liu ZG, Wang WP, Ye Y , Cao JJ. Characterization of binding interactions of (−)-epigallocatechin-3-gallate from green tea and lipase. Journal of Agricultural and Food Chemistry.2013, 61(37): 8829–883 （TOP 期刊）
Wu XL, Wu H, Xia LX, Ji KM, Liu ZG*, Chen JJ, Hu DS, Gao C, Wu Y. Socio-technical innovations for total food chain safety during the 2008 Beijing Olympics and Paralympics and beyond. Trends in Food Science & Technology, 2010,21(1): 44-51 （TOP 期刊）
Wu XL*, He WY, Zhang HP, Li Y, Liu ZG, He ZD*. Acteoside: A lipase inhibitor from the Chinese tea Ligustrum purpurascens kudingcha. Food Chemistry, 2014, 142(1):306-310 （TOP 期刊）
Wu XL*, Ye Y, Hu DH, LiuZG, CaoJJ. Food safety assurance systems in Hong Kong. Food Control.2014, 37(1):141-147
Wu XL*, Wang WP, Zhu T, Liang T, Lu FP, He WY, Zhang HP, Liu ZG, Gao KP, He SH, He ZD*. Phenylpropanoid glycoside inhibition of pepsin, trypsin and α-chymotrypsin enzyme activity in Kudingcha leaves from Ligustrum purpurascens. Food Research International, 2013, 54(2), 1376–1382.
Lu FQ, Wu XL*. China food safety hits the “gutter”. Food Control, July 2014, 41(1), 134-138.
Wu XL*, Li Y, Liu B,Feng Y, He WY, Liu ZG, Liu LZ, Wang ZM, Huang HZ*. Two-site antibody immunoanalytical detection of food allergens by surface plasmon resonance. Food Analytical Methods, 2016, 9(3): 582-588.
Feng Y, Fangqi L, Wu XL*, Li Y, Shen YX, Lu FQ, Fan L, He ZD. Inhibitory potential of phenylpropanoid glycosides from Ligustrum purpurascens Kudingcha against α-glucosidase and α-amylase in vitro, International Journal of Food Science &Technology.October, 2015, 50(10), 2280–2289.
Wu XL*, He WY, Ji KM, Wan WP, Hu DS, Wu H, Luo XP, Liu ZG. A simple and fast detection method for bovine milk residues in foods：a two-site monoclonal antibody immunochromatography assay. Journal of Food Science, 2013, 78(3)：452-457
Wu XL*, He WY, Wang WP, LuoXp, Cao Hy，Lin LX, Feng KQ, Liu ZG. Investigation of the interaction between (-)-epigallocatechin-3-gallate with trypsin and α-chymotrypsin. International Journal of Food Science &Technology. 2013, 48(11)：2340-2347.
Wu XL, Wu H*, Liu MX, Liu ZG*, Xu H, Lai FR.Analysis of binding interaction between (−)-epigallocatechin (EGC) and β-lactoglobulin by multi-spectroscopic method. SpectrochimActa A, 2011, 82(1): 164–168.
Lu YQ, Zhou WY, Feng Y, Li Y, Liu K , Liu LZ , Lin DX, He ZD, Wu XL*, Acteoside and acyl-migrated acteoside, compounds in chinese kudingcha tea, inhibit α-amylase in vitro. Journal of Medicinal Food . 2017, 20(6):577-585
Wu XL, Raje D, Wu H*, Liu ZG*, He QQ, Zeng XJ. Studies on the interaction of EGCG with bovine β-lactoglobulin by spectroscopic methods and docking. International Journal of Dairy Technology, 2013, 66(1): 7-13.
Wu XL, Wan WP，Xia LX, X Hong, Wu Hu*, Liu ZG*. In vitro refolding process of bovine allergen β-lactoglobulin by multi-spectroscopic method. Biomedical and Environmental Sciences, 2012, 25(3): 334-339.
Wu XL, Zhong XJ, Liu MX, Xia LX，Feng KQ, Wu H*, Liu ZG. Reduced allergenicity of β-lactoglobulin in vitro by tea catechins binding. Food and Agricultural Immunology, 2013, 24(3): 305-313
Wu XL, Liu MX, Xia LX, Wu H*, Liu ZG, Xu XF. Conjugation of functional oligosaccharides reduced in vitro allergenicity of β-lactoglobulin.Food and Agricultural Immunology, 2013, 24(4): 379-391
Li Y, Lu FQ, Feng Y, Wu XL*.Binding interaction between (−)-epigallocatechin-3-gallate (EGCG) of green tea and pepsin. Acta Alimentaria, 2016, 45(1): 129-140
Wu XL, Zhu QQ, Cheng XJ, Xu H, Liu ZG, Wu H*. Spectroscopic Studies on the Relationship between Heat Treatment Process and Immunogenicity of β-lactoglobulin in Milk. Spectroscopy and Spectral Analysis. 2011,31(8):2205-2209.
Wu XL, Zhu QQ, Cheng XJ, Xu H, Liu ZG*. Spectroscopic Studies on the Relationship between heat Treatment Process and Immunogenicity of Lysozyme in Hen’s Egg. Chinese Journal of Analytical Chemistry, 2011, 39(2) 198-202.
LL Shen, QQ Zhu, H Xu, XL Wu, HF Xiao, K Zhou, MYing, SL Tian, G Liu, ZL Hu, ZG Liu. Effect of heat treatment on structure and immunogenicity of recombinant peanut protein Ara h 2.01.LWT - Food Science and Technology, 2015, 60(2): 964-969.
Chen JJ, Xia LX, Wu XL, Yang SH, Ji KM, Liu ZG*, Tang MJ, Gao C. A practical test system for sensitive, rapid screening and authentication of peanut allergens in imported and exported food products in Chinese Customs Original Research Article. Food Control, 2012, 23(1): 154-158.
Hu XP, Shao MM, Song X, Wu XL, Qi L, Zheng K, Fan L, Liao CH, Li CY, He J, Hu YJ, Wu HQ, Li SH, Zhang J, Zhang FX, He ZD. Anti-influenza virus effects of crude phenylethanoid glycosides isolated from ligustrumpurpurascens via inducing endogenous interferon-γ. Journal of Ethnopharmacol. 2016, 179:128-36.
Zheng K, Liao C, Li Y, Fan X, Fan L, Xu H, Kang Q, Zeng Y, Wu X, Wu H, Liu L, Xiao X, Zhang J, Wang Y, He Z.Gypenoside L, Isolated from Gynostemmapentaphyllum, Induces Cytoplasmic Vacuolation Death in Hepatocellular Carcinoma Cells through Reactive-Oxygen-Species-Mediated Unfolded Protein Response.Journal of Agricuture&Food Chemistry. 2016, 64 (8): 1702–1711（TOP 期刊）
Liu ZG*, Liu H, Liu XY, Wu XL. Purification and cloning of a novel antimicrobial peptide from salivary glands of the hard tick, Ixodessinensis. Comparative Biochemistry & Physiology Part B Biochemistry & Molecular Biology, 2008, 149(4):557-561.
Ji KM, Chen JJ, Li M, Liu ZG*, Wang CB, Zhan ZK, Wu XL, Xia QY. Anaphylactic shock and lethal anaphylaxis caused by food consumption in China. Trends in Food Science & Technology, 2009, 20(5): 227-231.（TOP 期刊）
Ji KM*, Li CL, Meng G, Huan AD, Wu XL. New BZLF1 sequence variations in EBV-associated undifferentiated nasopharyngeal carcinoma in southern China，Archives of Virology, 2008, 153(10): 1949-1953.
Li M, Ji KM*, Liu ZG, Wang CB, Chen JJ, Zhan Zk, Wu XL, Food allergen labeling during the 2008 Beijing Olympics and Paralympics and beyond. Trends in Food Science & Technology, 2009, 20(2): 100-102.（TOP 期刊）
Ji KM*, Chen JJ, Li M, Liu ZG, Xia LX, Wang CB, Zhan ZK, Wu XL. Comments on serious anaphylaxis caused by nine Chinese herbal injections used to treat common colds and upper respiratory tract infections.Regulatory Toxicology & Pharmacology, 2009, 55(2): 134-138.
Zheng K, Jiang Y, Liao C, Hu X, Li Y, Zeng Y, Zhang J, Wu X, Wu H, Liu L, Wang Y, He Z*.NOX2-Mediated TFEB Activation and Vacuolization Regulate Lysosome-Associated Cell Death Induced by Gypenoside L, a Saponin Isolated from Gynostemmapentaphyllum.Journal of Agricuture & Food Chemistry. 2017, 65(31):6625-6637.（TOP 期刊）
Liao C, Zheng K, Li Y, Xu H, Kang Q, Fan L, Hu X, Jin Z, Zeng Y, Kong X, Zhang J, Wu X, Wu H, Liu L, Xiao X, Wang Y, He Z*.Gypenoside L inhibits autophagic flux and induces cell death in human esophageal cancer cells through endoplasm reticulum stress-mediated Ca2+ release.Oncotarget. 2016 , 26;7(30):47387-47402.
Zheng K, Li Y, Wang S, Wang X, Liao C, Hu X, Fan L, Kang Q, Zeng Y, Wu X, Wu H, Zhang J, Wang Y, He Z*.Inhibition of autophagosome-lysosome fusion by ginsenoside Ro via the ESR2-NCF1-ROS pathway sensitizes esophageal cancer cells to 5-fluorouracil-induced cell death via the CHEK1-mediated DNA damage checkpoint.Autophagy. 2016 ,12(9):1593-1613.
Xu H*, Shen LL, Hu ZL, Xiao J, Xiao HX, Wu JX, Li Y, Wei B, Ni Z, Wu XL, Liu ZG.Studies on Thermal Denaturation of Peanut Allergen Ara h1 and its Interaction with Reducing Sugars. Spectroscopy and Spectral Analysis. 2013, 33 (8):2128-31.
Gao K*, Wang J, Li L, Zhai Y, Ren Y, You H, Wang B, Wu X, Li J, Liu Z, Li X, Huang Y, Luo XP, Hu D, Ohno K, Wang C. Polymorphisms in Four Genes (KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China. International Journal of Environmental Research and Public Health. 2016, 26;13(3). pii: E260.
Ao Y, Zhang J, Liu Z, Qian M, Li Y, Wu Z, Sun P, Wu J, Bei W, Wen J, Wu X, Li F, Zhou Z, Zhu WG, Liu B*, Wang Z*. Lamin A buffers CK2 kinase activity to modulate aging in a progeria mouse model. Science Advances. 2019 Mar 20;5(3):eaav5078.（TOP 期刊）