个人简历

蔡毅，中山大学博士，麻省大学医学院博士后，助理教授。主要从事结核菌感染与免疫研究工作多年，主要研究方向是结核病免疫机制的研究和结核菌与宿主之间的相互作用和定向宿主治疗结核病新靶点的研究。共发表SCI论文12篇，其中以第一作者5篇，通讯作者一篇，发明专利7项。先后主持国家自然科学面上项目和青年科学基金各1项,深圳市学科布局项目1项,深圳市自由探索项目1项，参与十三五重大专项及国家自然科学基金多项。

研究领域

研究方向：
1疾病（结核）发展与细胞异质性
2细菌与宿主相互作用的机制
3 抗结核药物及其作用机制
4.结核病诊断分子标志。"主持项目：
国家自然科学基金 面上项目 NO.81770013

近期论文

Yang Q, Liao M, Wang W, Zhang M, Chen Q, Guo J, Peng B, Huang J, Liu H, Yahagi A, Xu X, Ishihara K, Cooper A, Chen X, Cai Y. 2019. CD157 confers host resistance to Mycobacterium tuberculosis via TLR2-CD157- PKCzeta-induced reactive oxygen species production. mBio 10:e01949-19
Cai Y，Yang Q，Liao M，Wang H，Zhang C，Nambi S，Wang W，Zhang M，Wu J，Deng G，Deng Q，Liu H，Zhou B，Jing Q，Feng C，Sassetti C，Wang F，Chen X，xCT increases tuberculosis susceptibility by regulating antimicrobial function and inflammation，Oncotarget，2016.05.24，7（21）：31001~31013
Cai Y，Yang Q，Tang Y，Zhang M，Liu H，Zhang G，Deng Q，Huang J，Gao Z，Zhou B，Feng C，Chen X，Increased Complement C1q Level Marks Active Disease in Human Tuberculosis，Plos One，2014.03.19，9
 Cai Y., Cheng Z., Li C., Wang F., Li G., and Pang Y. 2010. Biological activity of recombinant Spodoptera exigua multicapsid nucleopolyhedrovirus against Spodoptera exigua larvae. Biological Control 55:178-185.
Cai Y., Fan J., Sun S., Wang F., Yang K., Li G., and Pang Y. 2012. Interspecific interaction between Spodoptera exigua multiple nucleopolyhedrovirus and Microplitis bicoloratus in Spodoptera exigua larvae. Journal of Economic Entomology 105(5)
Cai Y，Long Z，Qiu J，Yuan M，Li G，Yang K，An ac34 Deletion Mutant of Autographa californica Nucleopolyhedrovirus Exhibits Delayed Late Gene Expression and a Lack of Virulence In Vivo，Journal of Virology，2012.07.11，86（19）：10432~10443
Qiu J, Tang Z, Cai Y, Wu W, Yuan M, Yang K. The Autographa californica Multiple Nucleopolyhedrovirus ac51 Gene Is Required for Efficient Nuclear Egress of Nucleocapsids and Is Essential for In Vivo Virulence, Journal of Virology, 2018 93(3)
Wu C, Deng Z, Long Z, Cai Y, Ying Z, Yin H, Yuan M, Clem R, Yang K, Pang Y, Generating a host range-expanded recombinant baculovirus, Scientific Report, 2016, 6:28072
Zhang G，Liu X，Wang W，Cai Y，Li S，Chen Q，Liao M，Zhang M，Zeng G，Zhou B，Feng C，Chen X(*)，Down-regulation of miR-20a-5p triggers cell apoptosis to facilitate mycobacterial clearance through targeting JNK2 in human macrophages，Cell cycle，2016.09.16，15（18）：2527~2538
Yang Q，Cai Y，Zhao W，Wu F，Zhang M，Luo K，Zhang Y，Liu H，Zhou B，Kornfeld H，Chen X，IP-10 and MIG Are Compartmentalized at the Site of Disease during Pleural and Meningeal Tuberculosis and Are Decreased after Antituberculosis Treatment，Clinical and vaccine Immunology，2014.12.01，21（12）：1635~1644
Yang Q, Xu Q, Chen Q, Li J, Zhang M, Cai Y, Liu H, Zhou Y, Deng G, Deng Q, Zhou B, Kornfeld H, Chen X, Discriminating Active Tuberculosis from Latent Tuberculosis Infection by flow cytometric measurement of CD161-expressing T cells, Scientific Reports 2015, 5:17918.