秦斌
近期热点
资料介绍
个人简历
秦斌,男,博士,副教授。2008年毕业于沈阳药科大学,获生命科学与技术基地班(生物技术制药)学士学位,2010年于同校获微生物与生化药学硕士学位,2013年获沈阳药科大学微生物与生化药学博士学位,毕业后赴日本东京大学进行博士后研究。2016年作为沈阳药科大学引进人才,被聘为副教授。入选2016-2018年度中国科协-中国药学会“青年人才托举工程”,作为课题负责人主持国家自然科学基金青年基金项目1项,辽宁省教育厅科学技术研究项目1项。目前已在AngewandteChemieInternationalEdition、ACSCatalysis、JournalofNaturalProducts等期刊发表论文20余篇,其中影响因子10以上的3篇。研究领域
研究方向一:生物催化与蛋白质工程:生物催化剂的发现及挖掘;通过蛋白工程提高生物催化剂的活性及选择性;手性药物及其中间体的生物催化合成;活性天然产物的生物转化等。研究方向二:天然产物生物合成与合成生物学:天然产物及其生物合成基因簇的挖掘;生物合成基因簇中关键酶的催化机制;萜合成酶及萜类化合物的生物合成等。近期论文
1.FengyuQin†,BinQin*,†,WenheZhang,YalinLiu,XinSu,TianhuiZhu,JingpingOuyang,JiyangGuo,YuxinLi,FeitingZhang,JunTang,XianJia,and,SongYou*,DiscoveryofaswitchbetweenPrelogandAnti-Prelogreductiontowardhalogen-substitutedacetophenonesinshort-chaindehydrogenase/reductases.ACSCatalysis2018,8(7),6012-6020.(†共同第一作者,*通讯作者)(IF:11.384)2.BinQin†,YudaiMatsuda†,TakahiroMori,MasahiroOkada,ZhiyangQuan,TakaakiMitsuhashi,ToshiyukiWakimoto,IkuroAbe*,AnunusualchimericditerpenesynthasefromEmericellavariecoloranditsfunctionalconversiontoasesterterpenesynthasebydomainswapping.AngewandteChemieInternationalEdition2016,55(5),1658-1661.(†共同第一作者)(封面文章,IF:12.102)3.FengyuQin†,BinQin†,TakahiroMori,YanWang,LingxinMeng,XinZhang,XianJia,IkuroAbe,SongYou*,EngineeringofCandidaglabrataketoreductase1forasymmetricreductionofα-haloketones.ACSCatalysis2016,6(9),6135-6140.(†共同第一作者)(IF:11.384)4.JiyangGuo,RuiZhang,JingpingOuyang,FeitingZhang,FengyuQin,GuigaoLiu,WenheZhang,HengyuLi,XiaohongJi,XianJia,BinQin*,SongYou*,Stereodivergentsynthesisofcarveolanddihydrocarveolthroughketoreductases/ene‐reductasescatalysedasymmetricreduction,ChemCatChem2018,10(23),5496-5504.(*通讯作者)(IF:4.674)5.YuxinLi†,BinQin†,XiaoqinLi,JunTang,YuChen,LinaZhou,SongYou*,SelectiveoxidationsofcyperenoicacidbyslightlyreshapingthebindingpocketofcytochromeP450BM3,ChemCatChem2018,10(3),559-565.(†共同第一作者)(IF:4.674)6.WenheZhang,TianhuiZhu,HengyuLi,FengyuQin,FeitingZhang,RuiZhang,XianJia,BinQin*,SongYou*,Keysitesinsightonthestereoselectivityoffourminedaldo-ketoreductasestowardα-ketoestersandhalogen-substitutedacetophenones,AppliedMicrobiologyandBiotechnology2019,accepted,DOI:10.1007/s00253-019-09932-7(*通讯作者)(IF:3.340)7.LihanZhang,TakuyaHashimoto,BinQin,JunkoHashimoto,IkukoKozone,TeppeiKawahara,MasahiroOkada,TakayoshiAwakawa,TakuyaIto,YoshinoriAsakawa,MasashiUeki,ShunjiTakahashi,HiroyukiOsada,ToshiyukiWakimoto,HaruoIkeda,KazuoShin-ya,IkuroAbe*,CharacterizationofgiantmodularPKSsprovidesinsightintogeneticmechanismforstructuraldiversificationofaminopolyolpolyketides.AngewandteChemieInternationalEdition2017,56(7),1740-1745.(扉页文章IF:12.102)8.MasahiroOkada,YudaiMatsuda,TakaakiMitsuhashi,ShotaroHoshino,TakahiroMori,KazuyaNakagawa,ZhiyangQuan,BinQin,HuipingZhang,FumiakiHayashi,HiroshiKawaide,IkuroAbe,Genome-baseddiscoveryofanunprecedentedcyclizationmodeinfungalsesterterpenoidsbiosynthesis.JournaloftheAmericanChemicalSociety2016,138(31),10011-10018.(IF:14.357)9.BinQin,YuxinLi,LingxinMeng,JingpingOuyang,DanniJin,LeiWu,XinZhang,XianJia,SongYou*,“Mirror-Image”manipulationofcurdionestereoisomerscaffoldsbychemicalandbiologicalapproaches:developmentofasesquiterpenoidlibrary.JournalofNaturalProducts2015,78(2),272-278.(IF:3.885)10.BinQin,PingLiang,XianJia,XinZhang,MaoMu,XiaoyingWang,GuozhenMa,DanniJin,SongYou*,DirectedevolutionofCandidaantarcticalipaseBforkineticresolutionofprofenesters.CatalysisCommunications2013,38,1-5.(IF:3.463) 相关热点
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