黄肖霄
近期热点
资料介绍
个人简历
黄肖霄,副教授。2014年毕业于沈阳药科大学天然药物化学专业,获得博士学位,毕业后留校任教,2016年12月被聘为副教授、硕士生导师。2015年11月进入中国人民解放军第二一〇医院开展博士后研究工作。目前主要承担本科天然药物化学、有机化合物波谱解析、药用活性成分的体外筛选等课程。科研主要方向为药用植物中活性先导化合物的快速发现,侧重于发现天然产物中的光学混合物并进行手性拆分,利用计算化学确定其立体构型,以光学纯的化合物为基础进行生物学研究,基于作用的靶点研究对映体活性差异性的原因。本人近年后主持国家自然科学基金面上项目1项、国家自然基金青年项目1项、博士后科学基金特别资助1项、博士后科学基金面上项目1项、以及省市级项目多项,并作为骨干成员参与了国家自然基金6项。近年在JournalofNaturalProducts、Phytochemistry、JounalofAgriculturalandFoodChemistry、EuropeanJournalofMedicinalChemistry等杂志上发表第一/通讯作者SCI论文72篇(对于天然产物中对映异构体的研究已经发表系列SCI论文27篇)。研究领域
研究方向一:药用植物中活性先导化合物的快速发现研究方向二:天然来源光学混合物的手性拆分及手性中心对于生物活性的影响近期论文
1.QiangRen,Wen-YuZhao,Shao-ChunShi,Feng-YingHan,Ying-YingZhang,Qing-BoLiu,Guo-DongYao,BinLin,Xiao-XiaoHuang*,Shao-JiangSong*.Guaiane-typesesquiterpenoidsfromtherootsofDaphnegenkwaandevaluationoftheirneuroprotectiveeffects.JournalofNaturalProducts.2019,82,1510−1517.(通讯作者;影响因子IF:4.257)2.Wen-YuZhao,Xiao-YuSong,LuZhao,Chun-XinZou,Wei-YuZhou,BinLin,Guo-DongYao,Xiao-XiaoHuang*,Shao-JiangSong*.QuassinoidsfromPicrasmaquassioidesandtheirneuroprotectiveeffects.JournalofNaturalProducts.2019,82,714−723.(通讯作者;影响因子IF:4.257)3.Xiao-LiQi,Ying-YingZhang,PengZhao,LeZhou,Xiao-BoWang,Xiao-XiaoHuang*,BinLin*,Shao-JiangSong*.ent-KauranediterpenoidswithneuroprotectivepropertiesfromCornSilk(Zeamays).JournalofNaturalProducts,2018,81:1225-1234.(通讯作者;影响因子IF:4.257)4.LeZhou,Guo-DongYao,Xiao-YuSong,JieWang,BinLin,Xiao-BoWang,Xiao-XiaoHuang*,andShao-JiangSong*.Neuroprotectiveeffectsof1,2-diarylpropanetypephenylpropanoidenantiomersfromredraspberryagainstH2O2-inducedoxidativestressinhumanneuroblastomaSH-SY5Ycells.JounalofAgriculturalandFoodChemistry.2018,66,331−338.(通讯作者;影响因子IF:3.571一区)5.LeZhou,Guo-DongYao,Li-WeiLu,Xiao-YuSong,BinLin,Xiao-BoWang,Xiao-XiaoHuang*,Shao-JiangSong*.NeolignansfromRedRaspberry(RubusidaeusL.)exhibitenantioselectiveneuroprotectiveeffectsagainstH2O2‑inducedoxidativeinjuryinSH-SY5YCells.JounalofAgriculturalandFoodChemistry.2018,66,11390−11397.(通讯作者;影响因子IF:3.571;一区)6.QianSun,Guo-DongYao,Xiao-YuSong,Xiao-LiQi,Yu-FeiXi,Ling-ZhiLi,Xiao-XiaoHuang*,Shao-JiangSong*.AutophagyantagonizesapoptosisinducedbyflavanenantiomersfromDaphnegiraldiiinhepaticcarcinomacellsinvitro.EuropeanJournalofMedicinalChemistry.133:1−10,2017.(通讯作者;影响因子IF:4.816)7.MingBai,Guo-DongYao,QiangRen,QinLi,Qing-BoLiu,YanZhang,Xiao-BoWang,Xiao-XiaoHuang*,Shao-JiangSong*.Triterpenoidsaponinsandflavonoidsfromlicoriceresidueswithanti-inflammatoryactivity.IndustrialCrops&Products,2018,125:50–58.(通讯作者;影响因子IF:4.191;一区)8.Xiao-LiQi,PengZhao,Ying-YingZhang,MingBai,BinLin,Xiao-XiaoHuang*,Shao-JiangSong*.Sesquiterpenesfromstigmamaydis(Zeamays)asacropby-productandtheirpotentialneuroprotectionandinhibitoryactivitiesofAβaggregation.IndustrialCrops&Products,2018,111:590–596.(通讯作者;影响因子IF:4.191;一区)9.LeZhou,JieWang,RuiGuo,BinLin,Xiao-BoWang,Xiao-XiaoHuang*,Shao-JiangSong*.DiscoveryofdihydrobenzofuranneolignansfromRubusideausL.withenantioselectiveanti-Aβ1-42aggregationactivity.BioorganicChemistry.2018,80:64-69.(通讯作者;影响因子IF:3.926)10.Si-FanLiu,BinLin,Yu-FeiXi,LeZhou,Li-LiLou,Xiao-XiaoHuang,*Xiao-BoWang*,Shao-JiangSong*.BioactivespiropyrrolizidineoxindolealkaloidenantiomersfromIsatisindigoticaFortune.Organic&BiomolecularChemistry.2018,16,9430–9439.(通讯作者;影响因子IF:3.423) 相关热点
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