个人简历

郭春，男，博士，制药工程学院药物化学教研室教授，博士生导师。1985年毕业于沈阳药学院，获化学制药学士学位，1993年于同校获药物化学硕士学位，2002年同校获药物化学博士学位，1999.9～2001.8美国加州大学旧金山分校（UCSF）访学，2004.11～2006.12东北制药集团企业博士后工作站博士后。近年来已完成国家、省、市纵向科研课题10余项，横向课题20余项。发表科研论文70余篇,主编、参编全国统编教材12部，出版译著1部；获授权发明专利10项。获国家级教学成果二等奖1项，省级教学成果二等奖5项。

研究领域

研究方向一：抗感染药物研究
研究方向二：抗肿瘤药物研究
研究方向三：药物合成工艺设计与优化

近期论文

1.HaonanYu,ZhuangHou,YeTian,YanhuaMou,ChunGuo,Design,synthesis,cytotoxicityandmechanismofnoveldihydroartemisinin-coumarinhybridsaspotentialanti-canceragents,EuropeanJournalofMedicinalChemistry,2018,151:434-449(IF=4.816)
2.Dan-JiaoWanga,1,ZhuangHoua,1,HangXua,RanAna,XinSub,,ChunGuo,Design,synthesis,andbiologicalevaluationof4-chloro-2H-thiochromenesfeaturingnitrogen-containingsidechainsaspotentanagents.Bioorganic&MedicinalChemistryLetters,(2018),doi:https://doi.org/10.1016/j.bmcl.2018.06.035(IF=2.44)
3.ZhuangHoua,1,BinLina,1,YuBaob,Hai-ningYana,MiaoZhanga,Xiao-weiChanga,
Xin-xinZhanga,Zi-jieWanga,Gao-feiWeia,Mao-shengChenga,YangLiua,ChunGuo,
Dual-tailapproachtodiscoveryofnovelcarbonicanhydraseIXinhibitorsbysimultaneouslymatchingthehydrophobicandhydrophilichalvesoftheactivesite,EuropeanJournalofMedicinalChemistry,2017,132:1-10(IF=3.9602)
4.ZhuangHou,YangLiu,Xin-xinZhang,Xiao-weiChang,Mao-shengCheng,ChunGuo,SynthesisofglucuronicacidderivativesviatheefficientandselectiveremovalofaC6methylgroup,TetrahedronLetters,2017,58:423–426(IF=2.347)
5.ChuanDu,XiaoyuWang,ShengfeiJin,HuiShi,YangmingLi,YadongPang,YangLiu,MaoshengCheng,ChunGuo,andYongxiangLiu,InvestigationofMeyer–SchusterRearrangementPromotedbyaSamarium(III)Triflate/N-FluorobenzenesulfonimideLewisAcidSystem,AsianJ.Org.Chem.2016,5,755.(IF=3.275)
6.YeTian,ZhenLiang,HangXu,YanhuaMouandChunGuo,Design,SynthesisandCytotoxicityofNovelDihydroartemisinin-CoumarinHybridsviaClickChemistry,Molecules,2016,21,758.(IF=2.465)
7.ZhenLiang,HangXu,YeTian,MengbiGuo,XinSuandChunGuo,Design,SynthesisandAntifungalActivityofNovelBenzofuran-TriazoleHybrids,Molecules,2016,21,732.(IF=2.465)
8.QidongTang,YanfangZhao,XinmingDu,Lian'eChong,PingGong,ChunGuo，Design,synthesis,andstructure-–activityrelationshipsofnovel6,7-disubstituted-4-phenoxyquinolinederivativesaspotentialantitumoragents，EuropeanJournalofMedicinalChemistry,Volume69,2013,77-89.(IF=3.499)
9.WeiLuo,Wei-QiangLu,Kun-QiangCui,YangLiu,JianWangChunGuo,N-{4-[(10S)-Dihydroartemisinin-10-oxyl]}phenylmethyl-N-(2-methylquinoline-4-yl)hydrazinederivativesasfalcipain-2inhibitors,MedChemRes,2012,21:3073–3079(IF=1.402)
10.YangLiu,WeiLuo,JianWang,JinHuang,Hong-linL,ChunGuo,Synthesisandbiologicalactivitiesofnovelartemisininderivativesascysteineproteasefalcipain-2inhibitors,Arch.Pharm.Res.2012,39(5):1525-31(IF=2.046)
“基于靶点的药物设计与研究”教育部重点实验室常务副主任，药物化学实验中心主任，“天然活性物质的结构改造与类药性研究”教育部创新团队骨干成员；《中国药物化学杂志》、《沈阳药科大学学报》、《国外药学》、《中国医科大学学报》等杂志编委；沈阳药科大学学位委员会药化分科、制药工程分科委员、化学工程与技术分科委员；沈阳药科大学学术委员会委员、沈阳药科大学咨询委员会委员；清华大学深圳研究生院“化学生物学研究室”、广东省“化学生物学重点实验室”客座教授