个人简历

关奇，男，博士，特聘副教授。2010年毕业于沈阳药科大学，获制药工程学士学位，2015年于同校获药物化学博士学位。2017年被聘为沈阳药科大学副教授。作为课题负责人主持了国家自然科学基金青年基金项目1项、辽宁省科技厅项目1项、辽宁省教育厅项目1项、沈阳市科技计划项目1项；另外，作为项目骨干成员承担国家自然科学基金应急项目1项。目前已在Green.Chem.,Cancer.Lett.,Eur.J.Med.Chem.,MedChemComm,Bioorg.Med.Chem.Lett.,等期刊发表论文10余篇。

研究领域

研究方向一：抗肿瘤及抗痛风创新药物研究
研究方向二：绿色化学合成方法研究及生物活性分子的新型构建方法研究
抗肿瘤及抗痛风创新药物研究与绿色化学合成方法研究

近期论文

1.QiGuan,MingyangJiang,JunhuiWu,YanpengZhai,YueWu,KaiBao*,WeigeZhang*.Directcyclebetweenco-productandreactant:anapproachtoimprovetheatomeconomyanditsapplicationinthesynthesisandprotectionofprimaryamines.Greenchemistry.18(2016)5794-5799.(IF=9.125)
2.QiGuan,ChunmingHan,DaiyingZuo,Min’anZhai,ZengqiangLi,QianZhang,YanpengZhai,XueweiJiang,KaiBao,YingliangWu*,WeigeZhang*.SynthesisandEvaluationofBenzimidazoleCarbamatesBearingIndoleMoietiesforAntiproliferativeandAntitubulinActivities.EuropeanJournalofMedicinalChemistry.2014,87,306-315(IF=4.519)
3.QiGuan,FushanYang,DandanGuo,JingwenXu,MingyangJiang,ChunjiangLiu,KaiBao,YingliangWu*,WeigeZhang*.SynthesisandBiologicalEvaluationofNovel3,4-Diaryl-1,2,5-selenadiazolAnaloguesofCombretastatinA-4.EuropeanJournalofMedicinalChemistry.2014,87,1-9(IF=4.519)
4.QiGuan,ZengjinCheng,XiaoxueMa,LijieWang,DongjieFeng,YuanhangCui,KaiBao,LanWu*,WeigeZhang*.SynthesisandBioevaluationof2-Phenyl-4-methyl-1,3-selenazole-5-carboxylicAcidsasPotentXanthineOxidaseInhibitors.EuropeanJournalofMedicinalChemistry.2014,85,508-516(IF=4.519)
5.QiGuan,DaiyingZuo,NanJiang,HuanQi,YanpengZhai,ZhaoshiBai,DongjieFeng,LeiYang,MingyangJiang,KaiBao,ChangLi,YingliangWu*,WeigeZhang*.Microwave-assistedSynthesisandBiologicalEvaluationof3,4-DiarylMaleicAnhydride/N-SubstitutedMaleimideDerivativesasCombretastatinA-4Analogues.Bioorganic&MedicinalChemistryLetters.2015,25(3),631-634(IF=2.454)
6.QiGuan1,DongjieFeng1,ZhaoshiBai,YuanhangCui,DaiyingZuo,Min’anZhai,XueweiJiang,WenboZhou,KaiBao,YingliangWu*,WeigeZhang*.Microwave-assistedSynthesis,MolecularDockingandAntiproliferativeActivityof3/5-Aryl-5/3-(3,4,5-trimethoxybenzoyl)-1,2,4-oxadiazolDerivatives.MedicinalChemistryCommunications.2015,6(8),1484-1493(IF=2.608)
7.AilongShi,DefaWang,HeWang,YueWu,HaiqiuTian,QiGuan*,KaiBao*,WeigeZhang*.Synthesisandbioevaluationof2-phenyl-5-methyl-2H-1,2,3-triazole-4-carboxylicacid/carbohydrazidederivativesaspotentxanthineoxidaseinhibitors.RSCAdvances.6(2016)114879-114888.(IF=3.108)