个人简历

池岛乔，男，博士，教授，博士生导师。1972年毕业于日本东北大学，获理学部生物学科学士学位，1974年于同校获理学研究科硕士学位，1978年获日本东北大学理学研究科博士学位。曾在日本横滨市立大学医学部、美国哈佛大学医学部、Tufts大学医学部任教，此后在日本万有制药株式会社（美国Merck公司的分公司）分子生物学研究所担任部长。1996年来到中国，在长春中医药大学担任教授，于2002年开始在沈阳药科大学任教。现为中日医药研究所所长。作为课题负责人主持了国家自然科学基金面上项目一项，作为主要参与人参与国家自然科学基金三项，辽宁省创新团队项目一项。在沈阳药科大学从事免疫药理学工作10余年来（2002年-），共发表SCI收录论文约200篇，学会发表论文约100篇（其中国际学会80余篇）

研究领域

""天然药物有效成分的抗炎、抗肿瘤、抗阿尔兹海默病及抗糖尿病药理学研究\r
天然药物影响细菌凋亡、自噬和衰老等过程的药理学研究\r
细胞外基质胶原明胶对细胞生理学和药理学的影响研究""""

近期论文

1.Zhang X1,Chen YR1,Zhao YL2,Liu WW1,Hayashi T3,Mizuno K4,Hattori S4,Fujisaki H4,Ogura T4,Onodera S5,Ikejima T6. (2019) Type I collagen or gelatin stimulates mouse peritoneal macrophages to aggregate and produce pro-inflammatory molecules through upregulated ROS levels.Int Immunopharmacol.27;76:105845. doi: 10.1016/j.intimp.2019.105845. [Epub ahead of print] (IF=3.361)\r
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2.Liu X1,Long X1,Gao Y1,Liu W1,Hayashi T1,2,Mizuno K3,Hattori S3,Fujisaki H3,Ogura T3,Onodera S4,Wang DO1,Ikejima T1,(2019)Type I collagen inhibits adipogenic differentiation via YAP activation in vitro.J Cell Physiol.. doi: 10.1002/jcp.29100. [Epub ahead of print] (IF=4.522)\r
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3.Sun Y1,Yang J1,2,Liu W1,Yao G3,4,Xu F1,Hayashi T1,5,Onodera S6,Ikejima T7,8(2019) Attenuating effect of silibinin on palmitic acid-induced apoptosis and mitochondrial dysfunction in pancreatic β-cells is mediated by estrogen receptor alpha.Mol Cell Biochem.460(1-2):81-92. doi: 10.1007/s11010-019-03572-1. (IF=2.884)\r
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4.Liu B1,Liu W1,Liu P1,Liu X1,Song X1,2,Hayashi T1,3,Onodera S4,Ikejima T5,6.(2019)Silibinin Alleviates the Learning and Memory Defects in Overtrained Rats Accompanying Reduced Neuronal Apoptosis and Senescence.Neurochem Res.44(8):1818-1829. doi: 10.1007/s11064-019-02816-2. (IF=2.782)\r
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5.Si L1,Liu W1,Hayashi T2,Ji Y1,Fu J1,Nie Y1,Mizuno K3,Hattori S3,Onodera S4,Ikejima T5.(2019) Silibinin-induced apoptosis of breast cancer cells involves mitochondrial impairment.Arch Biochem Biophys.671:42-51. doi: 10.1016/j.abb.2019.05.009. (IF=3.559)\r
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6.Yang J1,2,Sun Y1,Liu X1,Xu F1,Liu W1,Hayashi T1,3,Imamura Y3,Mizuno K4,Hattori S4,Tanaka K4,Fujisaki H4,Tashiro SI5,Onodera S6,Ikejima T1,7.(2019)Silibinin's regulation of proliferation and collagen gene expressions of rat pancreatic β-cells cultured on types I and V collagen involves β-catenin nuclear translocation.Connect Tissue Res.60(5):463-476. doi: 10.1080/03008207.2019.1593393.(IF=2.167)\r
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7.Yang J1,Sun Y1,Xu F1,Liu W1,Hayashi T1,2,Hattori S3,Ushiki-Kaku Y3,Onodera S4,Tashiro SI5,Ikejima T1,6.(2019)Silibinin protects rat pancreatic β-cell through up-regulation of estrogen receptors' signaling against amylin- or Aβ1-42 -induced reactive oxygen species/reactive nitrogen species generation.Phytother Res.33(4):998-1009. doi: 10.1002/ptr.6293.(IF=3.766)\r
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8.Zang L1,Wang J2,Ren Y2,Liu W2,Yu Y2,Zhao S2,Otkur W2,Zhao Y2,Hayashi T2,Tashiro SI3,Onodera S4,Ikejima T5.(2019)Activated toll-like receptor 4 is involved in oridonin-induced phagocytosis via promotion of migration and autophagy-lysosome pathway in RAW264.7 macrophages.Int Immunopharmacol.66:99-108. doi: 10.1016/j.intimp.2018.11.014.(IF=3.361)\r
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9.Zhao YL1,Zhang X1,Liu WW1,Yang YT1,Gao ZK1,Liu XL1,Liu W1,Hayashi T1,Yamato M2,Fujisaki H3,Hattori S3,Mizuno K3,Atsuzawa Y3,Tashiro SI4,Onodera S5,Ikejima T1.(2019)Reactive oxygen species are responsible for the cell aggregation and production of pro-inflammatory mediators in phorbol ester (PMA)-treated U937 cells on gelatin-coated dishes through upregulation of autophagy.Connect Tissue Res.2019 Jul;60(4):323-334. doi: 10.1080/03008207.2018.1530770.(IF=2.167)\r
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10.Yang J1,Sun Y1,Xu F1,Liu W1,Mai Y1,Hayashi T1,2,Hattori S3,Ushiki-Kaku Y3,Onodera S4,Tashiro SI5,Ikejima T6.(2019)Silibinin ameliorates amylin-induced pancreatic β-cell apoptosis partly via upregulation of GLP-1R/PKA pathway.Mol Cell Biochem.452(1-2):83-94. doi: 10.1007/s11010-018-3414-9.(IF=2.884)