个人简历

工作经历\r
2017−目前研究员, 上海中医药大学 创新中药研究院 手性药物研究中心\r
2010−2017副研究员,中国科学院 上海有机化学研究所 天然产物有机合成化学重点实验室\r
2006−2009项目组长, 晟康生物医药技术(上海)有限公司\r
2005−2006助研, 中国科学院 上海有机化学研究所 天然产物有机合成化学重点实验室\r
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教育背景\r
1999−2005博士, 中国科学院 上海有机化学研究所 (导师: 林国强 院士)\r
1995−1999本科, 武汉大学 化学与分子科学学院 (导师: 李早英 教授)\r
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学术荣誉\r
Thieme Chemistry Journal Awardees 2017\r
上海市高水平地方高校重点创新团队负责人 2017-2020\r
上海市优秀学术带头人 2020

研究领域

"""""基于过渡金属和有机催化剂的不对称催化\r
中药活性单体构效活性研究\r
基于中药的新药创制"

近期论文

Rhodium(III)-Catalyzed Asymmetric Reductive Cyclization of Cyclohexadienone-Containing 1,6-Dienes via an Anti-Michael/ Michael Cascade Process Hao Xu,# Yun-Xuan Tan,# Pei-Pei Xie,# Rui Ding, Qi Liao, Jian-Wei Zhang, Qing-Hua Li,* Yu-Hui Wang,* Xin Hong,* Guo-Qiang Lin, and Ping Tian* ACS Catal. 2021, 11, 8015−8022.\r
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A Retrospective Overview of PHGDH and Its Inhibitors for Regulating Cancer Metabolism Jia-Ying Zhao, Kai-Rui Feng, Feng Wang, Jian-Wei Zhang, Jay Fei Cheng,* Guo-Qiang Lin, Dingding Gao,* and Ping Tian* Eur. J. Med. Chem. 2021, 217, 113379.\r
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Muscone derivative ZM-32 inhibits breast tumor angiogenesis by suppressing HuR-mediated VEGF and MMP9 expression Liu-qing Yang,# Shao-peng Yu,# Yan-tao Yang, Yi-shuang Zhao , Fei-yun Wang , Yao Chen, Qing-hua Li, Ping Tian,* Yu-ying Zhu,* Jian-ge Zhang,* and Guo-qiang Lin Biomed. Pharmacother. 2021, 136, 111265.\r
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One-Pot Preparation of Tricyclo[5.2.2.04,9]undecanes via Cu-Catalyzed Asymmetric Carboboration of Cyclohexadienone-Tethered Allenes Kai-Rui Feng,# Yun-Xuan Tan,# Wenbo Ye, Yi-Fan Wang, Zhi-Tao He*, Ping Tian*, and Guo-Qiang Lin* Org. Lett. 2021, 23, 607–611 (K.-R.F. & Y.-X.T. contributed equally.)\r
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Palladium-catalyzed desymmetric [2+2+2] cycloaddition of 1,6-enyne and alkyne Wei-Cheng Zhao,# Xin Wang,# Juhua Feng,* Ping Tian,* and Zhi-Tao He* Tetrahedron 2021, 79, 131862.\r
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Rhodium(III)-catalyzed asymmetric carboboration of heterobicyclic alkenes Yun-Xuan Tan, Xing-Yu Liu, Cheng-Yu He,* and Ping Tian* Tetrahedron 2021, 77, 131739.\r
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Copper(I)-catalyzed asymmetric 1,6-conjugate allylation Chang-Yun Shi, Zhi-Zhou Pan, Ping Tian,* and Liang Yin* Nat. Commun. 2020, 11, 5480.\r
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Identification of novel STAT3 inhibitors bearing 2-acetyl-7-phenylamino benzofuran scaffold for antitumour study Feng Wang,# Kai-Rui Feng,# Jia-Ying Zhao, Jian-Wei Zhang, Xin-Wei Shi, Jian Zhou,* Dingding Gao,* Guo-Qiang Lin, and Ping Tian* Bioorg. Med. Chem. 2020, 28, 115822. (F.W. & K.-R.F. contributed equally.)\r
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One-Pot Preparation of Bridged Tricyclic and Fused Tetracyclic Scaffolds via Rhodium(III)-Catalyzed Asymmetric Borylative Cyclization Qing-Hua Li,# Dingding Gao,# Cheng-Yu He, Qi Liao, Yun-Xuan Tan, Yu-Hui Wang,* Rui Ding,* Guo-Qiang Lin, and Ping Tian* Cell Reports Physical Science 2020, 1, 100222. (Q.H.L. & D.G. contributed equally.)\r
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Synthesis of Chiral anti-1,2-Diamine Derivatives through Copper(I)-Catalyzed Asymmetric α-Addition of Ketimines to Aldimines Xu-Cheng Gan,# Cheng-Yuan Zhang,# Feng Zhong,# Ping Tian,* and Liang Yin* Nat. Commun. 2020, 11, 4473. (X.-C.G., C.-Y. Z., & F.Z. contributed equally.)\r
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Synthesis of Decahydrocyclobuta[cd]indene Skeleton: Rhodium(III)‐Catalyzed Hydroarylation and Relay Thiophene‐Promoted Intramolecular [2+2] Cycloaddition Dingding Gao,# Feng Wang,# Xing-Yu Liu, Kai-Rui Feng, Jia-Ying Zhao, Yu-Hui Wang,* Xiao-Di Yang,* Ping Tian* and Guo-Qiang Lin Adv. Synth. Catal. 2020, 362, 4384–4390. (D.G. & F.W. contributed equally.)\r
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Copper(I)-catalyzed Diastereo- and Enantio-selective Construction of Optically Pure Exocyclic Allenes Cheng-Yu He,# Yun-Xuan Tan,# Xin Wang, Rui Ding, Yi-Fan Wang, Feng Wang, Dingding Gao,* Ping Tian,* and Guo-Qiang Lin* Nat. Commun. 2020, 11, 4293. (C.-Y.H. & Y.-X.T. contributed equally.)\r
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Enantioselective [3+2] Annulation of Isatin-Derived MBH-Carbonates and 3-Nitroindoles Enabled by a Bifunctional DMAP-Thiourea Ming-Shun Mei,# Yu-Hui Wang,# Qing Hu, Qing-Hua Li, Da-Yu Shi, Dingding Gao,* Guangbo Ge,* Guo-Qiang Lin, and Ping Tian* Chem. Commun. 2020, 56, 10718–10721. (M.-M.S, & Y.-H.W. contributed equally.)\r
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An Unconventional trans-exo-Selective Cyclization of Alkyne-Tethered Cyclohexadienones Initiated by Rhodium(III)-Catalyzed C–H Activation via Insertion Relay Yun-Xuan Tan,# Xing-Yu Liu,# Shuo-Qing Zhang,# Pei-Pei Xie, Xin Wang, Kai-Rui Feng, Shao-Qian Yang, Zhi-Tao He,* Xin Hong,* Ping Tian,* and Guo-Qiang Lin* CCS Chem. 2020, 2, 1582–1595. (Y.-X.T, X.-Y.L. & S.-Q.Z. contributed equally.)\r
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Design, Synthesis and Biological Evaluation of Novel Potent STAT3 Inhibitors Based on BBI608 for Cancer Therapy Kai-Rui Feng,# Feng Wang,# Xin-Wei Shi, Yun-Xuan Tan, Jia-Ying Zhao, Jian-Wei Zhang, Qing-Hua Li ,* Guo-Qiang Lin, Dingding Gao,* and Ping Tian* Eur. J. Med. Chem. 2020, 201, 112428. (K.-R.F. & F.W. contributed equally)\r
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One-Pot Preparation of 9,10-Dihydrophenanthrenes Initiated by Rhodium(III)-Catalyzed C−H Activation and Relay Diels−Alder Reaction Dingding Gao,# Xing-Yu Liu,# Hao Xu,# Yun-Xuan Tan, Qi Liao, Qing-Hua Li,* Xiaodi Yang, Guo-Qiang Lin,* and Ping Tian* Org. Lett. 2020, 22, 4300−4305. ( D.D.G, X. -Y. L. & H. X. contributed equally)\r
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Nickel(II)-Catalyzed Addition of Aryl-, Alkenyl-, and Alkylboronic Acids to Alkenylazaarenes Xing-Yu Liu, Yun-Xuan Tan, Xin Wang, Hao Xu, Yu-Hui Wang,* Ping Tian,* and Guo-Qiang Lin* Org. Lett. 2020, 22, 4038−4042.\r
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Rhodium(III)-Catalyzed Kinetic Resolution of Racemic 1,6-Dienes via Asymmetric Borylative Cyclization Jun-Li Zhang,# Dingding Gao,# Yun-Xuan Tan, Cheng-Yu He, Pei-Ying Peng, Guo-Qiang Lin, Qing-Hua Li,* and Ping Tian* Org. Lett. 2020, 9, 3661−3666. (J.-L.Z. & D.D.G. contributed equally)\r
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Elucidation of the Structure of Pseudorubriflordilactone B by Chemical Synthesis Peng Yang,# Jian Li,# Li Sun, Ming Yao, Xiang Zhang, Wei-Lie Xiao, Jian-Hua Wang, Ping Tian,* Han-Dong Sun,* Pema-Tenzin Puno,* and Ang Li* J. Am. Chem. Soc. 2020, 142, 13701–13708. (P.Y. & J.L. contributed equally)\r
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Neuroprotective effect of salvianolate on cerebral ischaemia-reperfusion injury in rats by inhibiting the Caspase-3 signal pathway Pengwei Luan,# Jiazhen Xu,# Xinyue Ding, Qianfei Cui, Lixian Jiang, Yulan Xu, Yuying Zhu, Ruixiang Li, Guoqiang Lin, Ping Tian,* and Jiange Zhang* Eur. J. Pharmacol. 2020, 872, 172944. (P.W.L. & J.Z.X. contributed equally)