研究领域

"""""聚焦于结构生物学，利用生物化学与化学的方法，在分子水平上了解细胞信号传导的机制等。解析G蛋白偶联受体的高分辨率三维结构，并依据三维结构信息进行相应的药物研发。"

近期论文

1. Hanson MA, Roth CB, Jo E, Griffith MT, Scott FL, Reinhart G, Desale H, Clemons B, Cahalan SM, Schuerer SC, Sanna MG, HanGW, Kuhn P, Rosen H, Stevens RC. (2012) Crystal structure of a lipid G protein-coupled receptor. Science 335: 851-855
2. Liu JJ, Horst R, Katritch V, Stevens RC, Wüthrich K. (2012) Biased signaling pathways in β2-adrenergic receptor characterized by 19F-NMR. Science 335: 1106-1110
3. Wu H, Wacker D, Mileni M, Katritch V, Han GW, Vardy E, Liu W, Thompson AA, Huang XP, Carroll FI,
Mascarella SW, Westkaemper RB, Mosier PD, Roth BL, Cherezov V, Stevens RC. (2012) Structure of the human κ-opioid receptor in complex with JDTic. Nature 485: 327-332
4. Thompson AA, Liu W, Chun E, Katritch V, Wu H, Vardy E, Huang XP, Trapella C, Guerrini R, Calo G, Roth BL, Cherezov V, Stevens RC. (2012) Structure of the nociceptin/orphanin FQ receptor in complex with a peptide mimetic. Nature 485: 395-399
5. Liu W, Chun E, Thompson AA, Chubukov P, Xu F, Katritch V, Han GW, Roth CB, Heitman LH, IJzerman AP, Cherezov V, Stevens RC. (2012) Structural basis for allosteric regulation of GPCRs by sodium ions. Science 337: 232-236