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李健
2023-05-12 21:52
  • 李健
  • 李健 - 助理教授 研究员-上海科技大学-物质科学与技术学院-个人资料

近期热点

资料介绍

个人简历


2013年9月毕业于德国柏林工业大学(TechnischenUniversitätBerlin),获得自然科学博士学位(Dr.rer.nat.);随后于2013年12月至2017年8月在美国西北大学(NorthwesternUniversity)从事博士后研究;2017年9月加入上海科技大学物质科学与技术学院,任助理教授、研究员、博士生导师。2018年获上海市“浦江人才计划(A类)”资助。2018年8月起任SpringerNature出版社《SNAppliedSciences》杂志编委

研究领域


主要利用无细胞合成生物学(Cell-freeSyntheticBiology)等技术手段开展在蛋白、药物及健康等方面的研究工作"研究组主要利用无细胞合成生物学(Cell-freeSyntheticBiology)等技术手段开展在蛋白、药物及健康等方面的研究工作。主要研究内容包括:
1.新型无细胞蛋白合成体系的开发和利用;
2.无细胞生物合成具有重要工业和药用价值的蛋白质;
3.天然产物药物(如非核糖体多肽类抗生素)的生物合成、发现与开发;
4.新型蛋白质生物材料的设计、开发与应用"

近期论文


14.LiuWQ#,ZhangL#,ChenM#,LiJ*.Cell-freeproteinsynthesis:Recentadvancesinbacterialextractsourcesandexpandedapplications.BiochemicalEngineeringJournal,2019,141,182–189
13.LiJ*,ZhangL,LiuW.Cell-freesyntheticbiologyforinvitrobiosynthesisofpharmaceuticalnaturalproducts.SyntheticandSystemsBiotechnology,2018,3,83–89
12.WangH,LiJ*,JewettMC*.DevelopmentofaPseudomonasputidacell-freeproteinsynthesisplatformforrapidscreeningofgeneregulatoryelements.SyntheticBiology,2018,3,ysy003
PhDandPostdocpublications
11.CasiniA,ChangFY,EluereR,KingA,YoungEM,DudleyQM,KarimA,PrattK,BristolC,ForgetA,GhodasaraA,Warden-RothmanR,GanR,CristofaroA,EspahBorujeniA,RyuMH,LiJ,KwonYC,WangH,TatsisE,Rodriguez-LopezC,O'ConnorS,MedemaMH,FischbachM,JewettMC,VoigtCA,GordonDB.Apressuretesttomake10moleculesin90days:externalevaluationofmethodstoengineerbiology.JournaloftheAmericanChemicalSociety,2018,140,4302–4316
10.LiJ,WangH,JewettMC.ExpandingthepaletteofStreptomyces-basedcell-freeproteinsynthesissystemswithenhancedyields.BiochemicalEngineeringJournal,2018,130,29–33
9.LiJ,WangH,KwonYC,JewettMC.EstablishingahighyieldingStreptomyces-basedcell-freeproteinsynthesissystem.BiotechnologyandBioengineering,2017,114,1343–1353(VideoHighlighted)
8.GoeringAW#,LiJ#,McClureRA,ThomsonRJ,JewettMC,KelleherNL.InvitroreconstructionofnonribosomalpeptidebiosynthesisdirectlyfromDNAusingcell-freeproteinsynthesis.ACSSyntheticBiology,2017,6,39–44
7.LiJ,LawtonTJ,KosteckiJS,NisthalA,FangJ,MayoSL,RosenzweigAC,JewettMC.Cell-freeproteinsynthesisenableshighyieldingsynthesisofanactivemulticopperoxidase.BiotechnologyJournal,2016,11,212–218(FrontCover)
6.MoatsouD#,LiJ#,RanjiA,Pitto-BarryA,NtaiI,JewettMC,O’ReillyRK.Self-assemblyoftemperature-responsiveprotein-polymerbioconjugates.BioconjugateChemistry,2015,26,1890–1899(FrontCover)
5.LiJ*,JaitzigJ,LuP,SüssmuthRD,NeubauerP.Scale-upbioprocessdevelopmentforproductionoftheantibioticvalinomycininEscherichiacolibasedonconsistentfed-batchcultivations.MicrobialCellFactories,2015,14,83
4.LiJ*,JaitzigJ,TheuerL,LegalaOE,SüssmuthRD,NeubauerP.TypeIIthioesteraseimprovesheterologousbiosynthesisofvalinomycininEscherichiacoli.JournalofBiotechnology,2015,193,16–22
3.LiJ*,NeubauerP.Escherichiacoliasacellfactoryforheterologousproductionofnonribosomalpeptidesandpolyketides.NewBiotechnology,2014,31,579–585
2.LiJ#,JaitzigJ#,HilligF,SüssmuthRD,NeubauerP.EnhancedproductionofthenonribosomalpeptideantibioticvalinomycininEscherichiacolithroughsmall-scalehighcelldensityfed-batchcultivation.AppliedMicrobiologyandBiotechnology,2014,98,591–601
1.JaitzigJ#,LiJ#,SüssmuthRD,NeubauerP.ReconstitutedbiosynthesisofthenonribosomalmacrolactoneantibioticvalinomycininEscherichiacoli.ACSSyntheticBiology,2014,3,432–438

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