个人简历

学习经历 1991年9月 – 1995年6月: 湖北大学生物系，本科，生物教育专业 1997年9月 – 2000年6月: 中国科学院武汉病毒研究所，硕士，生物化学与分子生物学专业 2000年9月 – 2003年6月: 中国疾病预防控制中心，博士，病原生物学专业 工作经历 2003年10月 – 2008年4月: 新加坡基因组研究所，博士后 2008年5月 – 2009年12月: 剑桥大学生物医学研究所，助理研究员 2010年1月 – 至今：上海交通大学，特别研究员，教授

研究领域

主要研发各种高通量技术，利用高通量测序平台在干细胞及肿瘤细胞内开展包括转录组学、转录因子介导的转录调控网络以及表观遗传调控等领域在内的功能基因组学的研究。主要研究方向包括：1）肿瘤细胞转录调控网络；2）干细胞表观遗传修饰及其生物学意义。

近期论文

1. Gu Y, Wu J, Yang W, Xia C, Shi X, Li H, Sun J, Shao Z, Wu J, Zhao X*. STAT3 is required for proliferation and exhibits cell type-specific binding preference in mouse female germline stem cells. Mol. Omics, 2018;14(2):95-102. 2. Tan S, Li H, Zhang W, Shao Y, Liu Y, Guan H, Wu J, Zhu Y, Cai H, Chen C, Lobie PE, Zhao X*, Sun J*, Zhu T*. NUDT21 Negatively Regulates PSMB2 and CXXC5 by Alternative Polyadenylation and Contributes to Hepatocellular Carcinoma Suppression. Oncogene. 2018;37(35):4887-4900. 3. Zhang Q, Huang R, Ye Y, Guo X, Lu J, Zhu F, Gong X, Zhang Q, Yan J, Luo L, Zhuang S, Chen Y, Zhao X, Evans SM, Jiang C, Liang X, Sun Y. Temporal requirements for ISL1 in sympathetic neuron proliferation, differentiation, and diversification. Cell Death Dis. 2018; 9(2): 247. 4. Wu J, Xiao Y, Xia C, Yang F, Li H, Shao Z, Lin Z, Zhao X*. Identification of Biomarkers for Predicting Lymph Node Metastasis of Stomach Cancer Using Clinical DNA Methylation Data. Dis Markers. 2017; 2017:5745724. 5. Tan S, Ding K, Chong QY, Zhao J, Liu Y, Shao Y, Zhang Y, Yu Q, Xiong Z, Zhang W, Zhang M, Li G, Li X, Kong X, Ahmad A, Wu Z, Wu Q, Zhao X, Lobie PE, Zhu T. Post-transcriptional regulation of ERBB2 by miR26a/b and HuR confers resistance to tamoxifen in estrogen receptor-positive breast cancer cells. J Biol Chem. 2017; 292(33):13551-13564. 6. Zheng T, Que Z, Jiao L, Kang Y, Gong Y, Yao J, Ma C, Bi L, Dong Q, Zhao X, Xu L. Herbal formula YYJD inhibits tumor growth by inducing cell cycle arrest and senescence in lung cancer. Sci Rep. 2017;7(1):4984. 7. Zhang XL, Wu J, Wang J, Shen T, Li H, Lu J, Gu Y, Kang Y, Wong CH, Ngan CY, Shao Z, Wu J*, Zhao X*. Integrative epigenomic analysis reveals unique epigenetic signatures involved in unipotency of mouse female germline stem cells. Genome Biol. 2016;17(1):162. 8. Lu J, Chen J, Xu N, Wu J, Kang Y, Shen T, Kong H, Ma C, Cheng M, Shao Z, Xu L, Zhao X*. Activation of AIFM2 enhances apoptosis of human lung cancer cells undergoing toxicological stress. Toxicol Lett. 2016;258:227-36. 9. Lai DP, Tan S, Kang YN, Wu J, Ooi HS, Chen J, Shen TT, Qi Y, Zhang X, Guo Y, Zhu T, Liu B, Shao Z, Zhao X*. Genome-wide profiling of polyadenylation sites reveals a link between selective polyadenylation and cancer metastasis. Hum Mol Genet. 2015; 24(12): 3410-7. 10. Li H, Hou J, Bai L, Hu C, Tong P, Kang Y, Zhao X*, Shao Z*. Genome-wide Analysis of Core Promoter Structures in Schizosaccharomyces pombe with DeepCAGE. RNA Biol. 2015; 12(5): 525--537. 11. Qi Y, Zhang X, Kang Y, Wu J, Chen J, Li H, Guo Y, Liu B, Shao Z, Zhao X*. Genome-wide transcriptional profiling analysis reveals annexin A6 as a novel EZH2 target gene involving gastric cellular proliferation. Mol Biosyst. 2015; 11(7):1925-32. 12. Liang X, Zhang Q, Cattaneo P, Zhuang S, Gong X, Spann NJ, Jiang C, Cao X, Zhao X, Zhang X, Bu L, Wang G, Chen HS, Zhuang T, Yan J, Geng P, Luo L, Banerjee I, Chen Y, Glass CK, Zambon AC, Chen J, Sun Y, Evans SM. Transcription factor ISL1 is essential for pacemaker development and function. J Clin Invest. 2015; 125(8):3256-68. 13. Kang YN, Lai DP, Ooi HS, Shen TT, Kou Y, Tian J, Czajkowsky DM, Shao Z, Zhao X*. Genome-wide profiling of untranslated regions by paired-end ditag sequencing reveals unexpected transcriptome complexity in yeast. Mol Genet Genomics. 2015; 290(1):217-24. 14. Li J, Kent DG, Godfrey AL, Manning H, Nangalia J, Aziz A, Chen E, Saeb-Parsy K, Fink J, Sneade R, Hamilton TL, Pask DC, Silber Y, Zhao X, Ghevaert C, Liu P, Green AR. JAK2V617F homozygosity drives a phenotypic switch in myeloproliferative neoplasms, but is insufficient to sustain disease. Blood. 2014;123(20): 3139-51. 15. Zhao X, Ruan Y, Wei CL. Tackling the epigenome in the pluripotent stem cells. J Genet Genomics. 2008; 35(7):403-12. 16. Zhao X, Han X, Chew JL, Liu J, Chiu KP, Choo A, Orlov YL, Sung WK, Shahab A, Kuznetsov VA, Bourque G, Oh S, Ruan Y, Ng HH, Wei CL. Whole genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells. Cell Stem Cell, 2007; 1 (3):286-9. 17. ENCODE Project Consortium (including Zhao X). Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007; 447(7146):799-816. 18. Zeller KI#, Zhao X#, Lee CW, Chiu KP, Yao F, Yustein JT, Ooi HS, Orlov YL, Shahab A, Yong HC, Fu Y, Weng Z, Kuznetsov VA, Sung WK, Ruan Y, Dang CV, Wei CL. Global Mapping of c-MYC Binding Sites and Target Gene Networks in Human B Cells. Proc Natl Acad Sci USA. 2006; 103(47):17834-9. 19. Wei CL, Wu Q, Vega VB, Chiu KP, Ng P, Zhang T, Shahab A, Yong HC, Fu Y, Weng Z, Liu J, Zhao X, Chew JL, Lee YL, Kuznetsov VA, Sung WK, Miller LD, Lim B, Liu ET, Yu Q, Ng HH, Ruan Y. A global map of p53 ranscription- factor binding sites in the human genome. Cell. 2006; 124(1):207-19. 20. Loh YH, Wu Q, Chew JL, Vega VB, Zhang W, Chen X, Bourque G, George J, Leong B, Liu J, Wong KY, Sung KW, Lee CW, Zhao X, Chiu KP, Lipovich L, Kuznetsov VA, Robson P, Stanton LW, Wei CL, Ruan Y, Lim B, Ng HH. The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet. 2006;38(4):431-40.