个人简历

学习经历 1993-1996 博士 日本 东京大学 1991-1993 硕士 日本 东京大学 1982-1986 学士 山东大学 微生物学专业 工作经历 2006-至今 系统生物医学研究院 研究员 糖生物学与糖组学实验室 课题组长 中日（SCSB-AIST）医学糖组学联合实验室 中方主任 2004-2006 日本国立动物卫生研究所 特别研究员 1996-2004 日本产业技术综合研究所 助理研究员 1986-1989 上海交通大学生命科学与技术系 助教

研究领域

本实验室聚焦蛋白质糖基化调控和疾病糖链变化；运用多组学技术手段，研究蛋白质糖基化和糖链在疾病发生发展中的功能；致力于基于糖链的疾病诊断，药物开发等转化医学研究。主要研究方向：1. 蛋白质糖基化调控机制研究2. 疾病糖蛋白糖链生物标志物及其功能糖组学技术

近期论文

1. Shan, A. D., Lu, J. S., Xu, Z. J., Li, X.; Xu, Y. J., Li, W., Liu, F., Yang, F., Sato,T., Narimatsu, H. *, Zhang, Y.* Polypeptide N-acetylgalactosaminyltransferase 18 non-catalytically regulates the ER homeostasis and O-glycosylation. BBA-General Subjects 2019, ,1863(5),870-882 2. Yan, X. L., Lu, J. S., Zou, X., Zhang, S., Cui, Y. L., Zhou, L. Q., Liu, F., Shan, A. D., Lu, J. Y., Zheng, M. H., Feng, B.*, Zhang, Y.* The polypeptide N-acetylgalactosaminyltransferase 4 exhibits stage-dependent expression in colorectal cancer and affects tumorigenesis, invasion and differentiation. Febs J 2018, 285, 3041-3055. 3. Xu, W. P.; Wang, Z. R.; Zou, X.; Zhao, C.; Wang, R.; Shi, P. M.; Yuan, Z. L.; Yang, F.; Zeng, X.; Wang, P. Q.; Sultan, S.; Zhang, Y.*; Xie, W. F.*, Serum Wisteria floribunda agglutinin-positive Mac-2-binding protein evaluates liver function and predicts prognosis in liver cirrhosis. J Dig Dis 2018, doi: 10.1111/1751-2980.12596. 4. Zhu, M. Y.; Chen, P. Z.; Li, J.; Yu, D. M.; Huang, D.; Zhu, X. J.; Han, Y.; Chen, J.; Huang, W.; Chen, Y. Y.; Gong, Q. M.; Jiang, J. H.; Zhang, D. H.; Zhang, Y.; Zhang, J. M.; Zhang, X. X., Serum M2BPGi level is a novel predictive biomarker for the responses to pegylated interferon-alpha treatment in HBeAg-positive chronic hepatitis B patients. J Medical Virol 2018, 90(4), 721-729. 5. 崔雅璐; 徐颖姣; 贾文娟; 杨芳; 张延*, 疾病及发育中多肽:N-乙酰氨基半乳糖转移酶ppGalNAc-T的重要性. 生命科学 2018, 30(11): 1264-1274 6. Liu, F.; Xu, K.; Xu, Z. J.; de las Rivas, M.; Wang, C. R.; Li, X.; Lu, J. S.; Zhou, Y. Y.; Delso, I.; Merino, P.; Hurtado-Guerrero, R.*; Zhang, Y.*; Wu, F.*, The small molecule luteolin inhibits N-acetyl--galactosaminyltransferases and reduces mucin-type O-glycosylation of amyloid precursor protein. J Biol Chem 2017, 292(52), 21304-21319. 7. Xu, Z. J.; Li, X.; Zhou, S. M.; Xie, W. X.; Wang, J.; Cheng, L.; Wang, S.; Guo, S. J.; Xu, Z. W.; Cao, X.; Zhang, M. H.; Yu, B. A.; Narimatsu, H.; Tao, S. C.*; Zhang, Y.*, Systematic identification of the protein substrates of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T1/T2/T3 using a human proteome microarray. Proteomics 2017, 17, (11). 8. 张芳; 许之珏; 徐颖姣; 邹霞; 张延*, IgG糖基化与疾病相关性研究进展. 生命科学 2017, 04, 319-330. 9. Zhang, S.; Lu, J.; Xu, Z.; Zou, X.; Sun, X.; Xu, Y.; Shan, A.; Lu, J.; Yan, X.; Cui, Y.; Yan, W.; Du, Y.; Gu, J.; Zheng, M.; Feng, B.*; Zhang, Y.*, Differential expression of ST6GAL1 in the tumor progression of colorectal cancer. Biochem Biophys Res Commun 2017, 486(4), 1090-1096. 10. Zou, X.; Zhu, M. Y.; Yu, D. M.; Li, W.; Zhang, D. H.; Lu, F. J.; Gong, Q. M.; Liu, F.; Jiang, J. H.; Zheng, M. H.; Kuno, A.; Narimatsu, H.; Zhang, Y.*; Zhang, X. X.*, Serum WFA+-M2BP levels for evaluation of early stages of liver fibrosis in patients with chronic hepatitis B virus infection. Liver Int 2017, 37(1), 35-44. 11. Zou, X.; Yoshida, M.; Nagai-Okatani, C.; Iwaki, J.; Matsuda, A.; Tan, B.; Hagiwara, K.; Sato, T.; Itakura, Y.; Noro, E.; Kaji, H.; Toyoda, M.; Zhang, Y.; Narimatsu, H.; Kuno, A., A standardized method for lectin microarray-based tissue glycome mapping. Sci Rep 2017, 7, 43560. 12. Xu, Y.; Pang, W.; Lu, J.; Shan, A.; Zhang, Y.*, Polypeptide N-Acetylgalactosaminy ltransferase 13 Contributes to Neurogenesis via Stabilizing the Mucin-type O-Glycoprotein Podoplanin. J Biol Chem 2016, 291(45), 23477-23488. 13. Zou, X.; Chi, X.; Pan, Y.; Du, D.; Sun, H.; Matsuda, A.; Li, W.; Kuno, A.; Zhang, X.; Narimatsu, H.; Niu, J.*; Zhang, Y.*, LecT-Hepa facilitates estimating treatment outcome during interferon therapy in chronic hepatitis C patients. Clin Proteomics 2014, 11(1), 44. 14. Tan, B.; Matsuda, A.; Zhang, Y.; Kuno, A.; Narimatsu, H., Multilectin-assisted fractionation for improved single-dot tissue glycome profiling in clinical glycoproteomics. Mol Biosyst 2014, 10 (2), 201-205. 15. Yu, D. M.; Li, X. H.; Mom, V.; Lu, Z. H.; Liao, X. W.; Han, Y.; Pichoud, C.; Gong, Q. M.; Zhang, D. H.; Zhang, Y.; Deny, P.; Zoulim, F.; Zhang, X. X., N-glycosylation mutations within hepatitis B virus surface major hydrophilic region contribute mostly to immune escape. J Hepatol 2014, 60(3), 515-522. 16. Zhang, X.; Zhang, Y.*, Applications of Azide-Based Bioorthogonal Click Chemistry in Glycobiology. Molecules 2013, 18(6), 7145-7159. 17. Zou, X.; Feng, B.; Dong, T. T.; Yan, G. Q.; Tan, B. B.; Shen, H.; Huang, A.; Zhang, X.; Zhang, M. H.; Yang, P. Y.; Zheng, M. H.; Zhang, Y.*, Up-regulation of type I collagen during tumorigenesis of colorectal cancer revealed by quantitative proteomic analysis. J Proteomics 2013, 94, 473-485. 18. Tan, B. B.; Qiu, Y. P.; Zou, X.; Chen, T. L.; Xie, G. X.; Cheng, Y.; Dong, T. T.; Zhao, L. J.; Feng, B.; Hu, X. F.; Xu, L. X.; Zhao, A. H.; Zhang, M. H.; Cai, G. X.; Cai, S. J.; Zhou, Z. X.; Zheng, M. H.; Zhang, Y.*; Jia, W.*, Metabonomics Identifies Serum Metabolite Markers of Colorectal Cancer. J Proteome Res 2013, 12(6), 3000-3009. 19. Aoki-Kinoshita, K. F.; Sawaki, H.; An, H. J.; Campbell, M.; Cao, Q. C.; Cummings, R.; Hsu, D. K.; Kato, M.; Kawasaki, T.; Khoo, K. H.; Kim, J.; Kolarich, D.; Li, X. Y.; Liu, M. Q.; Matsubara, M.; Okuda, S.; Packer, N. H.; Ranzinger, R.; Shen, H. L.; Shikanai, T.; Shinmachi, D.; Toukach, P.; Yamada, I.; Yamaguchi, Y.; Yang, P. Y.; Ying, W. T.; Yoo, J. S.; Zhang, Y.; Zhang, Y.; Narimatsu, H., The Fifth ACGG-DB Meeting Report: Towards an International Glycan Structure Repository. Glycobiology 2013, 23(12), 1422-1424.