徐岷涓
近期热点
资料介绍
个人简历
学习经历 1.2001/9–2006/7, 北京大学, 生药学, 博士 2.1997/9–2001/7, 北京大学, 药学, 学士 工作经历 1.2010/3-至今,上海交通大学,系统生物医学研究院,副研究员 2.2008/5-2010/2,北京大学,天然药物与仿生药物国家重点实验室,助理研究员 3.2006/9-2008/4,德国维尔茨堡大学,博士后,洪堡学者研究领域
结构复杂、活性多样的天然 产物是现代药物的重要组成部分和新药发现的重要来源,徐岷涓博士主要研究领域为天然药物化学和药学,包括新结构类型的发现、新生物活性的筛选、 新生物合成机理的解析,并结合大规模代谢网络建模构建药物的生物合成体系,为创新海洋药物研究服务。近期论文
1. Combinatory Biosynthesis of Prenylated 4 Hydroxybenzoate Derivatives by Overexpression of the Substrate-Promiscuous Prenyltransferase XimB in Engineered E. coli Bei-Bei He(#); Xu-Liang Bu(#); Ting Zhou; Shu-Ming Li; Min-Juan Xu(*); Jun Xu(*) ACS Synth. Biol., 2018, 7: 2094~2104 2. Deciphering the streamlined genome of Streptomyces xiamenensis 318 as the producer of the anti-fibrotic drug candidate xiamenmycin Xu Min Juan(#); Wang Jia Hua; Bu Xu Liang; Yu He Lin; Li Peng; Ou Hong Yu; He Ying; Xu Fang Di; Hu Xiao Yan; Zhu Xiao Mei; Ao Ping; Xu Jun(*) Scientific Reports, 2016, 6: 18977 3. Structural diversity of anti-pancreatic cancer capsimycins identified in mangrove-derived Streptomyces xiamenensis 318 and post-modification via a novel cytochrome P450 monooxygenase Yu He Lin(#); Jiang Shu Heng; Bu Xu Liang; Wang Jia Hua; Weng Jing Yi; Yang Xiao Mei; He Kun Yan; Zhang Zhi Gang; Ao Ping; Xu Jun(*); Xu Min Juan(*) Scientific Reports, 2017, 7(1): 40689 4. Total synthesis and stereochemical revision of xiamenmycin A Jiao Xiaozhen(#); Yao Yangyang; Yang Beibei; Liu Xiaoyu; Li Xiaoyu; Yang Hongguang; Li Li; Xu Jun; Xu Minjuan(*); Xie Ping(*) Organic and Biomolecular Chemistry, 2016, 14(5): 1805~1813 5. Xiamenmycin Attenuates Hypertrophic Scars by Suppressing Local Inflammation and the Effects of Mechanical Stress Liu, Xiao-Jin(#); Xu, Min-Juan(#); Fan, Si-Teng; Wu, Zheng; Li, Jun; Yang, Xiao-Mei; Wang, Ya-Hui; Xu, Jun(*); Zhang, Zhi-Gang(*) Journal of Investigative Dermatology, 2013, 133(5): 1351~1360 6. Characterization of the Xiamenmycin Biosynthesis Gene Cluster in Streptomyces xiamenensis 318 Yang, Yong(#); Fu, Ling; Zhang, Jinlong; Hu, Linghan; Xu, Minjuan(*); Xu, Jun(*) PLos One, 2014, 9(6): e99537 7. In Vivo Metabolism Study of Xiamenmycin A in Mouse Plasma by UPLC-QTOF-MS and LC-MS/MS Lei Feng(#); Gao Du; Zhang Xi; Xu Jun; Xu Min Juan(*) Marine Drugs, 2015, 13(2): 727~740 8. Identification and Characterization of an Anti-Fibrotic Benzopyran Compound Isolated from Mangrove-Derived Streptomyces xiamenensis Xu, Min-Juan(#); Liu, Xiao-Jin(#); Zhao, Yi-Lei; Liu, Dong; Xu, Zhen-Hao; Lang, Xiao-Meng; Ao, Ping; Lin, Wen-Han; Yang, Song-Lin; Zhang, Zhi-Gang(*); Xu, Jun(*) Marine Drugs, 2012, 10(3): 639~654 相关热点
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