个人简历

学习经历 2000.09-2004.06 北京大学，学士 2004.09-2009.06 中国科学院上海生命科学研究院，生物信息学博士 工作经历 2009.06-2009.12 复旦大学生命科学院，博士后 2009.10-2012.12 上海交通大学系统生物医学研究院，助理研究员 2013.01至今 上海交通大学系统生物医学研究院，副研究员 2014.02-2016.02 加州大学伯克利分校，唐氏学者

研究领域

以计算生物学和生物信息学方法为手段，研究重要生物大分子（如蛋白质、核酸等）的结构、功能以及其调控机制，研究有机小分子（如小分子药物等）与生物大分子的相互作用及其调控相应生物学过程的具体机制。

近期论文

1. Wang S, Chen J, Garcia SP, Liang X, Zhang F, Yan P, Yu H, Wei W, Li Z, Wang J, Le H, Han Z, Luo X, Day DS, Stevens SM, Zhang Y, Park PJ, Liu ZJ, Sun K, Yuan GC, Pu WT*, Zhang B*. A dynamic and integrated epigenetic program at distal regions orchestrates transcriptional responses to VEGFA. Genome Res. 2019, 29(2): 193-207. 2. Ying B, Pang S, Yang J, Zhong Y, Wang J*. Computational Study of HCV p7 Channel: Insight into a New Strategy for HCV Inhibitor Design. Interdiscip. Sci. 2018, doi: 10.1007/s12539-018-0306-3. 3. Cheng L, Liu CX, Jiang S, Hou S, Huang JG, Chen ZQ, Sun YY, Qi H, Jiang HW, Wang JF, Zhou YM, Czajkowsky DM, Dai J, Tao SC*. Cell Lysate Microarray for Mapping the Network of Genetic Regulators for Histone Marks. Mol. Cell. Proteomics 2018, 17(9): 1720-1736. 4. Wang Z, Zhao Q, Cui M, Pang S, Wang J, Liu Y, Xie L*. Probing Temperature- and pH-Dependent Binding between Quantum Dots and Bovine Serum Albumin by Fluorescence Correlation Spectroscopy. Nanomaterials 2017, 7(5): E93. 5. Qi H, Zhou H, Czajkowsky DM, Guo S, Li Y, Wang N, Shi Y, Lin L, Wang J, Wu, Tao SC*. Rapid Production of Virus Protein Microarray Using Protein Microarray Fabrication through Gene Synthesis (PAGES). Mol. Cell. Proteomics 2017, 16(2): 288-299. 6. Xu Z, Huang L, Zhang H, Li Y, Guo S, Wang N, Wang SH, Chen Z, Wang J*, Tao SC*. PMD: A resource for archiving and analyzing protein microarray data. Sci. Rep. 2016, 6: 19956. 7. Zhang HN, Yang L, Ling JY, Czajkowsky DM, Wang JF, Zhang XW, Zhou YM, Ge F, Yang MK, Xiong Q, Guo SJ, Le HY, Wu SF, Yan W, Liu B, Zhu H, Chen Z*, Tao SC*. Systematic identification of arsenic-binding proteins reveals that hexokinase-2 is inhibited by arsenic. Proc. Natl. Acad. Sci. USA 2015, 112(49): 15084-15089. 8. Yang L#, Wang J#, Li J, Zhang H, Guo S, Yan M, Zhu Z, Lan B, Ding Y, Xu M, Li W, Gu X, Qi C, Zhu H, Shao Z, Liu B*, Tao SC*. Identification of serum biomarkers for gastric cancer diagnosis using a human proteome microarray. Mol. Cell. Proteomics 2016, 15(2): 614-623. #co-first author 9. Liu F, Zhao YL, Wang X, Hu H, Peng H, Wang W, Wang JF, Zhang X*. Elucidation of enzymatic mechanism of phenazine biosynthetic protein PhzF using QM/MM and MD simulations. PLoS One 2015, 10(9): e0139081. 10. Fa B, Cong S, Wang J*. Pi-pi stacking mediated cooperative mechanism for human cytochrome P450. Molecules 2015, 20(5): 7558-7573. 11. Hu Q, Wang J, Fu Z, Mo X, Ding X, Xia L, Zhang Y, Sun Y*. The distribution pattern of DNA and protoxin in Bacillus thuringiensis as revealed by laser confocal microscopy analysis. Appl. Microbiol. Biotechnol. 2015, 99(13): 5605-5612. 12. Deng J, Bi L, Zhou L, Guo SJ, Fleming J, Jiang HW, Zhou Y, Gu J, Zhong Q, Wang ZX, Lu Z, Deng RP, Gao J, Chen T, Li W, Wang JF, Wang X, Li H, Ge F, Zhu G, Zhang HN, Gu J, Wu FL, Zhang Z, Wang D, Hang H, Li Y, Cheng L, He X, Tao SC*, Zhang XE*. Mycobacterium tuberculosis proteome microarray for global studies of protein function and immunogenicity. Cell Rep. 2014, 9(6): 2317-2329. 13. Xia XL, Fa BT, Cong S, Wang JF*, Chou KC*. Insights into the mutation-induced dysfunction of arachidonic acid metabolism from modeling of human CYP2J2. Curr. Drug Metab. 2014, 15(5): 502-513. 14. Yu Y, Li X, Hao P, Wang JF*, Chou KC*. Structure and linkage disequilibrium analysis of adamantane resistant mutations in influenza virus M2 proton channel. Curr. Drug Metab. 2014, 15(5): 526-534. 15. Wang Y, Chen M, Wang H, Wang JF*, Bao D*. Microsatellites in the genome of the edible mushroom, volvariella volvacea. Biomed. Res. Int. 2014, 2014: 281912. 16. Xiong F, Xia L, Wang J, Wu B, Wang D, Yuan L, Cheng Y, Zhu H, Che X, Zhang Q, Zhao G, Wang Y*. A high-affinity CDR-grafted antibody against influenza A H5N1 viruses recognizes a conserved epitope of H5 hemagglutinin. PLoS One 2014, 9(2): e88777. 17. Sun Y, Zhao Q, Zheng D, Ding X, Wang J, Hu Q, Yuan Z, Park HW, Xia L*. Construction and characterization of the interdomain chimeras using Cry11Aa and Cry11Ba from Bacillus thuringiensis and identification of a possible novel toxic chimera. Biotechnol. Lett. 2014, 36(1): 105-111. 18. Ping J, Hao P, Li YX, Wang JF*. Molecular dynamics studies on the conformational transitions of adenylate kinase: a computational evidence for the conformational selection mechanism. Biomed. Res. Int. 2013, 2013: 628536. 19. Wu C, Liu J, Pan X, Xian W, Li B, Peng W, Wang J, Yang D, Zhou H*. Design, synthesis and evaluation of the antibacterial enhancement activities of amino dihydroartemisinin derivatives. Molecules 2013, 18(6): 6866-6882. 20. Ma L, Wang Y, Wang J*, Li X, Hao P*. Expression sensitivity analysis of human disease related genes. Biomed. Res. Int. 2013, 2013: 637424.