个人简历

学习经历 1996.03-1999.07 大连理工大学 博士学位 1991.09-1994.07 大连理工大学 硕士学位 1987.09-1991.07 大连理工大学 学士学位 工作经历 2011年1月-- 上海交通大学系统生物医学研究院，研究员，博士生导师 2004.10- 2010.12 中国科学院上海应用物理研究所，中科院“百人计划”, 研究员，博士生导师 2002.03-2004.09 美国科罗拉多州立大学(Colorado State University)博士后 1999.07-2002.01 中国科学院上海有机化学研究所，助理研究员 1994.07-1996.03 中国科学院大连化学物理研究所，实习研究员

研究领域

核酸化学生物学，荧光标记核苷酸在DNA合成测序以及单分子测序中的应用 嵌段共聚物自组织胶束作为药物/基因运输载体研究

近期论文

1. Lianjiang Tan*, Ran Huang, Xiaoqiang Li, Shuiping Liu, Yu-Mei Shen* Controllable release of nitric oxide and doxorubicin from engineered nanospheres for synergistic tumor therapy Acta Biomaterialia 2017, 57, 498-510. 2. Xueli Wang, Changyu He, Qinglai Yang, Lianjiang Tan, Bingya Liu, Zhenggang Zhu, Bing Gong*, Yu-Mei Shen* Dynamic covalent linked triblock copolymer micelles for glutathione-mediated intracellular drug delivery Materials Science and Engineering C 2017, 77, 34-44. 3. Lianjiang Tan*, Ran Huang, Xiaoqiang Li, Yu-Mei Shen*, Zhifeng Shao Chitosan-based core-shell nanomaterials for pH-triggered release of anticancer drug and near-infrared bioimaging Carbohydrate Polymers 2017, 157, 325-334. 4. Changyu He, Qinglai Yang, Lianjiang Tan, Bingya Liu, Zhenggang Zhu, Bing Gong, Yu-Mei Shen*, Zhifeng Shao Dual Redox and Oxidative Stress Responsive Block Copolymer Micelles for Drug Delivery European Polymer Journal 2016, 85, 38-52. 5. Changyu He, Zhen Zhang, Qinglai Yang, Qing Chang, Bing Gong, Zhifeng Shao, Yu-Mei Shen*, Bingya Liu*, Zhenggang Zhu Reductive triblock copolymer with dynamic covalent linkage delivers antimiR-21 for gastric cancer’s treatment Polymer Chemistry 2016, 7, 4352-4366. 6. Wei Hu, Changyu He, Lianjiang Tan, Bingya Liu, Zhenggang Zhu, Bing Gong, Yu-Mei Shen*, Zhifeng Shao Synthesis and Micellization of Redox-Responsive Dynamic Covalent Multi-block Copolymers Polymer Chemistry 2016, 7, 3145-3155. 7. Qinglai Yang, Changyu He, Zhen Zhang, Lianjiang Tan, Bingya Liu, Zhenggang Zhu, Zhifeng Shao, Bing Gong, Yu-Mei Shen* Redox-responsive flower-like micelles of poly(L-lactic acid)-b-poly(ethylene glycol)- b-poly(L-lactic acid) for intracellular drug delivery Polymer 2016, 90, 351-362. 8. Lianjiang Tan, Yazhi Liu, Xiaowei Li, Xin-Yan Wu, Bing Gong, Yu-Mei Shen*, Zhifeng Shao Synthesis and evaluations of an acid-cleavable, fluorescently labeled nucleotide as a reversible terminator for DNA sequencing Chemical Communications 2016, 52, 2549-2552. 9. Lianjiang Tan, Yazhi Liu, Qinglai Yang, Xiaowei Li, Xin-Yan Wu, Bing Gong, Yu-Mei Shen*, Zhifeng Shao Design and synthesis of fluorescence-labeled nucleotide with azo cleavable linker for DNA sequencing Chemical Communications 2016, 52, 954-957. 10. Lianjiang Tan*, Shuiping Liu, Qinglai Yang, Yu-Mei Shen* Facile assembly of oppositely charged silver sulfide nanoparticles into photo- luminescent mesoporous nanospheres Langmuir 2015, 31 (13), 3958–3964. 11. Qinglai Yang, Lianjiang Tan, Changyu He, Bingya Liu, Yuhong Xu, Zhenggang Zhu, Zhifeng Shao, Bing Gong, Yu-Mei Shen* Redox-Responsive Micelles Self-assembled from Dynamic Covalent Block Copolymers for Intracellular Drug Delivery Acta Biomaterialia 2015, 17, 193-200. 12. Qinglai Yang, Changyu He, Yuhong Xu, Bingya Liu, Zhifeng Shao, Zhenggang Zhu, Yongtai Hou, Bing Gong and Yu-Mei Shen* Chitosan oligosaccharide copolymer micelles with double disulphide linkage associated by H-bonding duplexes for targeted intracellular drug delivery Polymer Chemistry 2015, 6, 1454-1464. 13. Lianjiang Tan*, Shuiping Liu, Xiaoqiang Li, Ioannis S. Chronakis, Yu-Mei Shen* A new strategy for synthesizing AgInS2 quantum dots emitting brightly in near infrared window for in vivo imaging Colloid Surface B: Biointerfaces 2015, 125, 222-229. 14. Qinglai Yang, Ling Bai, Yuanqing Zhang, Fangxia Zhu, Yuhong Xu, Zhifeng Shao, Yu-Mei Shen,* Bing Gong* Dynamic Covalent Block Copolymers: Instructed Coupling, Micellation and Redox Responsiveness Macromolecules 2014, 47, 7431-7441. 15. Daonian Tang, Min Jiang, Xiaowei Li, Yani Kang, Xin-Yan Wu, Bing Gong*, Zhifeng Shao, Xiaodong Zhao, Yu-Mei Shen* Synthesis and Application of Four Fluorescence Labeled Nucleotides through Disulfide Bond as Reversible Terminators in DNA Sequencing by Synthesis Chemical Journal of Chinese Universities 2014, 35(11), 2346-2352. 16. Min Jiang, Daonian Tang, Xiaodong Zhao, Qing Li, Xiaofei Wei, Xiaowei Li, Yazhi Liu, Xin-Yan Wu, Zhifeng Shao, Bing Gong*, Yu-Mei Shen* Design and synthesis of new acid cleavable linkers for DNA sequencing by synthesis Nucleoside, Nucleotide and Nucleic Acids 2014, 33, 774-785. 17. Fangxia Zhu, Qinglai Yang, Yuan Zhuang, Yuangqing Zhang, Zhifeng Shao, Bing Gong* and Yu-Mei Shen*; Self-assembled Polymeric Micelles Based on THP and THF linkage for pH-Responsive Drug Delivery Polymer 2014, 55, 2977-2985. 18. Yuanqing Zhang, Yanhong Sun, Xiaoping Xu, Xuezhu Zhang, Hua Zhu, Liliang Huang, Yujin Qi, Yu-Mei Shen* Synthesis, Biodistribution, and Microsingle Photon Emission Computed Tomography (SPECT) Imaging Study of Technetium-99m Labeled PEGylated Dendrimer Poly(amidoamine) (PAMAM)-Folic Acid Conjugates Journal of Medicinal Chemistry 2010, 53, 3262–3272. 19. Yu-Mei Shen, Mei-Xin Zhao, Jiaxi Xu, and Yian Shi* An Amine-Promoted NH-Aziridination of a, b-Unsaturated Ketones Angew. Chem. Int. Ed. 2006, 45, 8005-8008. 20. Yu-Mei Shen, Bin Wang and Yian Shi* Enantioselective Synthesis of 2-Aryl Cyclopentanones by Asymmetric Epoxidation and Epoxide Rearrangement Angew. Chem. Int. Ed. 2006, 45, 1429-1432.