个人简历

学习经历 2003/09-2006/06, 复旦大学，神经生物学系，博士 2000/09-2003/06，华中农业大学，作物遗传育种，硕士 1996/09-2000/06，华中农业大学，作物遗传育种，学士 工作经历 1. 2016/1-至今，上海交通大学，系统生物医学研究院，副研究员 2. 2013/2-2015/12，上海交通大学，系统生物医学研究院，助理研究员 3. 2008/06-2012/08，美国埃默里大学，病理系，博士后，合作导师：Keqiang Ye 4. 2007/01-2008/05， 美国匹兹堡大学，神经病学系，博士后，合作导师：Michael J. Zigmond

研究领域

""肿瘤治疗新靶点新疗法""""

近期论文

1. Zhang QW ; Bu SX ; Sun JY; Xu MH; Yao XF; He KY; Lai DM*. Paracrine effects of human amniotic epithelial cells protect against chemotherapy-induced ovarian damage, Stem Cell Res Ther, 2017.11.28, 8(1): 270~283 2. Yu HL, Jiang SH, Bu XL, Wang JH, Weng JY, Yang XM, He KY, Zhang ZG, Ao P, Xu J, Xu MJ. Structural diversity of anti-pancreatic cancer capsimycins identified in mangrove-derived Streptomyces xiamenensis 318 and post-modification via a novel cytochrome P450 monooxygenase. Sci Rep. 2017 Jan 18;7:40689. doi: 10.1038/srep40689 3. Shi Y, Su XB, He KY, Wu BH, Zhang BY, Han ZG. Chromatin accessibility contributes to simultaneous mutations of cancer genes. Sci Rep. 2016 Oct 20;6:35270. doi: 10.1038/srep35270. 4. Wang X., Zhang Y., Han Z., He K#. Malignancy of Cancers and Synthetic Lethal Interactions Associated With Mutations of Cancer Driver Genes. Medicine (Baltimore). 2016 Feb;95(8):e2697. doi: 10.1097/MD.0000000000002697. (#Corresponding author) 5. Han B., He K., Cai C., Tang Y., Yang L., Heinemann SH., Hoshi T., Hou S. Human EAG channels are directly modulated by PIP2 as revealed by electrophysiological and optical interference investigations. Science Report. 2016 Mar 23;6:23417. doi: 10.1038/srep23417. 6. He, K., Qi, Q., Chan，C., Xiao,G., Liu, X., Tucker-Burden, C., Wang, L., Mao, H., Lu, X., McDonald, F., Luo, H., Fan, W., Weiss, W., Sun, S., Brat, D., and Ye, K. Blockade of Glioma Proliferation Through Allosteric Inhibition of JAK2. Science Signaling, 2013. Jul 9; 6(283):ra55. 7. Qi Q, He K, Liu X, Pham C, Meyerkord C, Fu H, and Ye, K.. Disrupting the PIKE-A/Akt interaction inhibits glioblastoma cell survival, migration, invasion, and colony formation. Oncogene, 2013. Feb 21; 32(8): 1030-40. 8. Qi, Q., He, K., Yoo, M.H., Chan, C.B., Liu, X., Zhang, Z., Olson, J.J., Xiao, G., Wang, L., Mao, H., Fu, H., Sun, S.Y., Michel, P.S. and Ye, K. Acridine yellow G blocks glioblastoma growth via dual inhibition of epidermal growth factor receptor and protein kinase C Kinases. J Biol Chem, 2012, 287(9):6113-27 (Co-first author) 9. He, K., Jang, S.W., Joshi, J., Yoo, M.H. and Ye, K. Akt-phosphorylated PIKE-A Inhibits UNC5B-induced Apoptosis in Cancer Cell Lines in a P53-dependent Manner. Mol Biol Cell, 2011, 22(11):1943-1954. 10. He, K., Liu, X., Chan, C.B., Jia, Y., Luo, Y.R., France, S.A., Ye, K. Identification of a Small Molecular Activator for Insulin Receptor with Potent Anti-diabetic Effects in Mice. J Biol Chem, 2011 Oct 28; 286(43): 37379-88. 11. Chan, C.B., Liu, X., He, K., Qi, Q., Jung, D., Kim, J. and Ye, K.. The association of phosphoinositide 3-kinase enhancer A with hepatic insulin receptor enhances its kinase activity. EMBO Rep, 2011, 12(8): 847-854. 12. Liu, X., Chan, C.B., Jang, S.W., Pradoldej, S., Huang, J., He, K., Phun, L.H., France, S., Xiao, G., Jia, Y., Luo, H.R. and Ye, K. A Synthetic 7,8-Dihydroxyflavone Derivative Promotes Neurogenesis and Exhibits Potent Antidepressant Effect. J Med Chem, 2010, 53(23): 8274-8286. 13. He, K., Yang, S., Shen, D., Zhang, L., Lu, S. and Sun, F. Excision repair cross complementing 1 express protects brain against ischemic injury following middle cerebral artery occlusion in rat brain. Gene Ther, 2009, 16(7): 840–848.