个人简历

学习经历 1984.9-1987.6，江苏省卫生学校，医学检验； 1993.9-1997.6，江苏徐州医学院，临床医学； 2000.9-2003.6, 江苏徐州医学院（硕士研究生），肿瘤学； 2004.9-2007.6, 复旦大学（博士研究生），分析化学。 2007.9-2009.6，上海交通大学（博士后），肿瘤基因组学和分子遗传学 工作经历 1987.8-1995.6, 徐州医学附属医院检验科，医学检验师； 1995.7-1997.6, 徐州医学附属医院医务科，主管检验师； 1997.7-2001.1, 徐州医学附属医院中心实验室，主管检验师； 2001.2-2004,6 国家人类基因组南方研究中心，客座研究； 2004.7-2009.11, 国家人类基因组南方研究中心，课题组长； 2009.11-2011.6 深圳华大基因研究院健康事业研发中心主任； 2011.7-2015.5生物芯片上海国家工程研究中心肿瘤基因组学转化应用研究室主任； 2011.6-至今 国家人类基因组南方研究中心/上海市疾病与健康基因组学省部共建重点实验室课题组长； 2015.6-至今 上海交通大学系统生物医学研究院/疾病基因组学研究室主任，系统生物医学教育部重点实验室副主任。

研究领域

1. 肿瘤基因组变异的基础和应用研究2. 肝癌发病机制研究及治疗药物研发3. 宫颈癌筛查、早诊和预后技术研究

近期论文

1. Jian Huang#*, Zhaoyang Qian, Yuhua Gong, Yanzhou Wang3, Yanfang Guan, Yingxin Han, Xin Yi, Wanqiu Huang, Liyan Ji, Jiajia Xu, Mengyuan Su, Qing Yuan, Shujian Cui, Chaohui Bao, Weilong Liu, Xi Chen, Ming Zhang, Xiaohuan Gao, Renhua Wu, Yinxin Zhang, Huicheng Xu, Shida Zhu, Hongmei Zhu, Ling Yang, Xun Xu, Pingyu Zhou*, Zhiqing Liang*. Comprehensive genomic variation profiling of cervical intraepithelial neoplasia and cervical cancer identifies potential targets for cervical cancer early warning. Journal of Medical Genetics. 2018 Dec 19. pii: jmedgenet-2018-105745. doi: 10.1136/jmedgenet-2018-105745. 2. Yan An†, Yanfang Guan†, Yaping Xu†, Yingxin Han†, Chi Wu4, Chaohui Bao, Boping Zhou, Haiyan Wang, Mingxia Zhang, Weilong Liu, Lin Qiu1, Zeguang Han, Yongsheng Chen, Xuefeng Xia, Jiayin Wang, Wanqiu Huang*, Xin Yi*, Jian Huang*. Blood circulating DNA content and mutations for diagnosis and prognosis determination of hepatocellular carcinoma using targeted panel sequencing. Molecular Oncology, 2019, submitted. 3. Xin Zou, Wei Cao, Jian Huang*, Jie Hao*, Ze-Guang Han*. Optimal Gene Filtering for Single-Cell data (OGFSC) – a gene filtering algorithm for single-cell RNA-seq data. Bioinformatics. 2018 Dec 10. doi: 10.1093/bioinformatics/bty1016. 4. Liu Yang, Song Ye, Xinyi Zhao, Liyan Ji, Yinxin Zhang, Pingyu Zhou, Jun Sun, Yanfang Guan, Yingxin Han, Chao Ni, Xiaoge Hu, Weilong Liu, Haiyan Wang, Boping Zhou, and Jian Huang*. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. Journal of Cancer. J Cancer. 2018 Sep 7;9(18):3225-3235. doi: 10.7150/jca.26052. eCollection 2018. 5. Yu Q, Cheng Y, Wang Y, Wang C, Lu H, Guan Z, Huang J, Gong W, Shi M, Ni L, Wu J, Peng R, Zhou P. Aberrant Humoral Immune Responses in Neurosyphilis: CXCL13/CXCR5 Play a Pivotal Role for B-Cell Recruitment to the Cerebrospinal Fluid. J Infect Dis. 2017 Sep 1; 216(5):534-544. 6. Yu YQ, Li J, Liao Y, Chen Q, Liao WJ, Huang J*. The preoperative alkaline phosphatase-to-platelet ratio index is an independent prognostic factor for hepatocellular carcinoma after hepatic resection. Medicine (Baltimore). 2016 Dec; 95(51):e5734. 7. Qiudao Wang, Yan An. Ying Ou, Qing Yuan, Yao Qi, Junhui Chen, Jian Huang*. Identification of allelic expression imbalance genes in human hepatocellular carcinoma through massively parallel DNA and RNA sequencing. Med Oncol. 2016 Apr; 33(4):38. doi: 10.1007/s12032-016-0751-y. Epub 2016 Mar 21. 8. Jun Sun, Zhefeng Meng, Kaiqi Wu, Yuezhu Wang, Huajun Zheng, Jian Huang*, Pingyu Zhou*. Tracing the origin of Treponema pallidum in China using next generation sequencing. Oncotarget. 2016 Jul 12; 7(28):42904-42918. doi: 10.18632/oncotarget.10154. 9. Xing Liu, Weijia Liao, Qing Yuan, Ying Ou, Jian Huang*. TTK can significantly promote the proliferation and migration of hepatocellular carcinoma cells as a novel therapeutic target via Akt activation. Oncotarget. 2015 Oct 27;6(33):34309-20. doi: 10.18632/oncotarget.5295. 10. Changhai Tian, Yuju Li, Yunlong Huang, Yongxiang Wang, Dapeng Chen, Jinxu Liu, Xiaobei Deng, Lijun Sun, Kristi Anderson, Xinrui Qi, Yulong Li, R. Lee Mosley, Xiangmei Chen, Jian Huang, Jialin C. Zheng. Selective Generation of Dopaminergic Precursors from Mouse Fibroblasts by Direct Lineage Conversion. Sci Rep. 2015 Jul 30; 5: 12622. doi: 10.1038/srep12622. 11. Yingxin Han, Hongmei Li, Yanfang Guan, Jian Huang*. Immune repertoire: a potential biomarker and therapeutic for hepatocellular carcinoma. Cancer Lett. 2015 Jul 15. pii: S0304-3835(15)00441-3. doi: 10.1016/j.canlet.2015.06.022. 12. Weijia Liao, Weilong Liu, Xing Liu, Qing Yuan, Ying Ou, Yao Qi, Wanqiu Huang, Yun Wang, Jian Huang*. Upregulation of FAM83D affects the proliferation and invasion of hepatocellular carcinoma. Oncotarget. 2015 Sep 15;6(27):24132-47. 13. Yingxin Han, Xing Liu, Yuqi Wang, Xiaolei Wu, Yanfang Guan, Xinchun Chen, Boping Zhou, Qing Yuan, Ying Ou, Renhua Wu, Wanqiu Huang, Yun wang, Ming Zhang, Yinxin Zhang, Dongxing Zhu, Hongmei Zhu, Ling Yang, Xin Yi, Chen Huang & Jian Huang*. Identification of characteristic TRB V usage in HBV-associated HCC by using differential expression profiling analysis. Oncoimmunology. 2015 Apr 2;4(8):e1021537. eCollection 2015. 14. Zhang ZZ, Huang J, Wang YP, Cai B, Han ZG. NOXIN as a cofactor of DNA polymerase-primase complex could promote hepatocellular carcinoma. Int J Cancer. 2015 Aug 15;137(4):765-75. 15. Hu X, Wan S, Ou Y, Zhou B, Zhu J, Yi X, Guan Y, Jia W, Liu X, Wang Q, Qi Y, Yuan Q, Huang W, Liao W, Wang Y, Zhang Q, Xiao H, Chen X, Huang J*. RNA over-editing of BLCAP contributes to hepatocarcinogenesis identified by whole-genome and transcriptome sequencing. Cancer Lett. 2015 Feb 28;357(2):510-9. 16. Gao F, Xia Y, Wang J, Lin Z, Ou Y, Liu X, Liu W, Zhou B, Luo H, Zhou B, Wen B, Zhang X, Huang J*. Integrated analyses of DNA methylation and hydroxymethylation reveal tumor suppressive roles of ECM1, ATF5 and EOMES in human hepatocellular carcinoma. Genome Biol. 2015 Jan 3;15(12):533. 17. Cai Y, Yang Q, Tang Y, Zhang M, Liu H, Zhang G, Deng Q, Huang J, Gao Z, Zhou B, Feng CG, Chen X. Increased complement C1q level marks active disease in human tuberculosis. PLoS One. 2014 Mar 19;9(3):e92340. 18. Ying Gu, Kangmo Lu, Guanghui Yang, Zhong Cen, Li Yu, Lin Lin, Jing Hao, Zhigang Yang, Jiabao Peng, Shujian Cui, Jian Huang*. Mutation spectrum of six genes in Chinese phenylketonuria patients obtained through next-generation sequencing. PLoS One. 2014; 9(4):e94100. 19. Weijia Liao, Weilong Liu, Qing Yuan, Xing Liu, Ying Ou, Songqing He, Shengguang Yuan, Liling Qin, Qian Chen, Kate Nong, Minghui Mei, Jian Huang*. Silencing of DLGAP5 by siRNA significantly inhibits the proliferation and invasion of hepatocellular carcinoma cells. PLoS One. 2013; 8(12):e80789. 20. Wei X, Ju X, Yi X, Zhu Q, Qu N, Liu T, Chen Y, Jiang H, Yang G, Zhen R, Lan Z, Qi M, Wang J, Yang Y, Chu Y, Li X, Guan Y, Huang J*. Identification of Sequence Variants in Genetic Disease Genes using Targeted Next-Generation Sequencing. PLoS One. 2011;6(12):e29500. Epub 2011 Dec 21.