个人简历

学习经历 1981年9月至1986年7月 南京医科大学医疗系学习，获学士学位 1988年9月至1991年7月 南京医科大学内科（血液学专业）硕士研究生，获硕士学位 1995年9月至1998年7月 上海第二医科大学血液学研究所博士研究生，获博士学位 工作经历 2013年4月-迄今 上海交通大学系统生物医学研究院常务副院长、教育部系统生物医学重点实验室主任 2014年4月-迄今 上海交通大学转化医学研究院副院长。 1998年7月-迄今 国家人类基因组南方研究中心研究员、功能基因组部主任、省市共建国家重点实验室（基地）常务副主任、上海交通大学特聘教授、长江学者特聘教授 1991年7月-1995年8月 徐州医学院附属医院 助理研究员、主治医师、讲师 1986年7月-1988年8月 江苏徐州市第三医院内科 住院医师

研究领域

1） 肿瘤（肝癌）发病机制研究：从遗传和表观遗传、细胞信号通路及代谢等方面研究与肝癌相关的重要基因的功能及其调节肿瘤发生和发展的分子机制；研究肿瘤相关重要基因突变的作用和机制；基于对肿瘤发生发展机制的研究，针对特定的靶点，应用新策略开发新疗法。 2） 功能基因组学相关技术研究和开发：目前集中进行单细胞分析及其数据分析的算法及软件研发。

近期论文

1. Hao J, Cao W, Huang J, Zou X, Han ZG. Optimal Gene Filtering for Single-Cell data (OGFSC) - a gene filtering algorithm for single-cell RNA-seq data. Bioinformatics. 2018 Dec 10. doi: 10.1093 2. Yuan Y, Shi Y, Su X, Zou X, Luo Q, Feng DD, Cai W, Han ZG. Cancer type prediction based on copy number aberration and chromatin 3D structure with convolutional neural networks. BMC Genomics. 2018 Aug 13;19(Suppl 6):565. 3. Huang LY, Zhao J, Chen H, Wan L, Inuzuka H, Guo J, Fu X, Zhai Y, Lu Z, Wang X, Han ZG, Sun Y, Wei W. SCFFBW7-mediated degradation of Brg1 suppresses gastric cancer metastasis. Nat Commun. 2018 Sep 3;9(1):3569. 4. Huang LY, Wang X, Cui XF, Li H, Zhao J, Wu CC, Min L, Zhou Z, Wan L, Wang YP, Zhang C, Gao WQ, Sun Y, Han ZG. IRTKS is correlated with progression and survival time of patients with gastric cancer. Gut. 2018 Aug;67(8):1400-1409 5. Yuan Y, Shi Y, Su X, Zou X, Luo Q, Feng DD, Cai W, Han ZG. Cancer type prediction based on copy number aberration and chromatin 3D structure with convolutional neural networks. BMC Genomics. 2018 Aug 13;19(Suppl 6):565. 6. Su X, Shi Y, Zou X, Lu ZN, Xie G, Yang JYH, Wu CC, Cui XF, He KY, Luo Q, Qu YL, Wang N, Wang L, Han ZG. Single-cell RNA-Seq analysis reveals dynamic trajectories during mouse liver development. BMC Genomics. 2017 Dec 4;18(1):946. 7. Cheng S, Wang L, Deng CH, Du SC, Han ZG. ARID1A represses hepatocellular carcinoma cell proliferation and migration through lncRNA MVIH. Biochem Biophys Res Commun. 2017 Sep 9;491(1):178-182. 8. Xia P, Liu J, Wang S, Ye B, Du Y, Xiong Z, Han ZG, Tong L, Fan Z. WASH maintains NKp46+ ILC3 cells by promoting AHR expression. Nat Commun. 2017 Jun 7;8:15685. 9. Dai YJ, Wang YY, Huang JY, Xia L, Shi XD, Xu J, Lu J, Su XB, Yang Y, Zhang WN, Wang PP, Wu SF, Huang T, Mi JQ, Han ZG, Chen Z, Chen SJ. Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement. Proc Natl Acad Sci U S A. 2017 May 16;114(20):5237-5242 10. Sagner M, McNeil A, Puska P, Auffray C, Price ND, Hood L, Lavie CJ, Han ZG, Chen Z, Brahmachari SK, McEwen BS, Soares MB, Balling R, Epel E, Arena R. The P4 Health Spectrum - A Predictive, Preventive, Personalized and Participatory Continuum for Promoting Healthspan. Prog Cardiovasc Dis. 2017 Mar - Apr;59(5):506-521 11. Cao W, Liu JN, Liu Z, Wang X, Han ZG, Ji T, Chen WT, Zou X. A three-lncRNA signature derived from the Atlas of ncRNA in cancer (TANRIC) database predicts the survival of patients with head and neck squamous cell carcinoma. Oral Oncol. 2017 Feb;65:94-101. 12. Wang X, Cao W, Zhang J, Yan M, Xu Q, Wu X, Wan L, Zhang Z, Zhang C, Qin X, Xiao M, Ye D, Liu Y, Han Z, Wang S, Mao L, Wei W, Chen W. A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination. EMBO J. 2017 May 2;36(9):1243-1260 13. Chen J, Fu Y, Day DS, Sun Y, Wang S, Liang X, Gu F, Zhang F, Stevens SM, Zhou P, Li K, Zhang Y, Lin RZ, Smith LEH, Zhang J, Sun K, Melero-Martin JM, Han Z, Park PJ, Zhang B, Pu WT. VEGF amplifies transcription through ETS1 acetylation to enable angiogenesis. Nat Commun. 2017 Aug 29;8(1):383 14. Shi Y, Su XB, He KY, Wu BH, Zhang BY, Han ZG. Chromatin accessibility contributes to simultaneous mutations of cancer genes. Sci Rep. 2016 Oct 20;6:35270. 15. Cai CM, Xiao X, Wu BH, Wei BF, Han ZG. Targeting endogenous DLK1 exerts antitumor effect on hepatocellular carcinoma through initiating cell differentiation. Oncotarget. 2016 Nov 1;7(44):71466-71476. 16. Yin M, Liu X, Xu B, Huang J, Zheng Q, Yang Z, Feng Z, Han ZG, Hu W. Genetic variation between Schistosoma japonicum lineages from lake and mountainous regions in China revealed by resequencing whole genomes. Acta Trop. 2016 Sep;161:79-85. 17. Wu BH, Chen H, Cai CM, Fang JZ, Wu CC, Huang LY, Wang L, Han ZG. Epigenetic silencing of JMJD5 promotes the proliferation of hepatocellular carcinoma cells by down-regulating the transcription of CDKN1A. Oncotarget. 2016 Feb 9;7(6):6847-63 18. Wang X, Zhang Y, Han ZG, He KY. Malignancy of Cancers and Synthetic Lethal Interactions Associated With Mutations of Cancer Driver Genes. Medicine (Baltimore). 2016 Feb;95(8):e2697 19. Yuan Y, Shi Y, Li C, Kim J, Cai W, Han Z, Feng DD. DeepGene: an advanced cancer type classifier based on deep learning and somatic point mutations. BMC Bioinformatics. 2016 Dec 23;17(Suppl 17):476. 20. Fang JZ, Li C, Liu XY, Hu TT, Fan ZS, Han ZG. Hepatocyte-Specific Arid1a Deficiency Initiates Mouse Steatohepatitis and Hepatocellular Carcinoma. PLoS One. 2015 Nov 16;10(11):e0143042.