学习经历 2005-2010 Ph.D. in Physical Chemistry with Prof. Yun-Dong Wu, Peking University. 2001-2005 B.Sc in Chemistry, Inner Mongolia University. 工作经历 2017.1-now Shanghai Jiaotong University 2014.05-2015.11 Postdoctoral with Prof. Huan-Xiang Zhou in Florida State University. 2013.09-2014.05 Postdoctoral with Prof. Xuhui Huang in Chemistry Department, Hong Kong University of Science and Technology. 2013.03-2013.09 Visiting scholar with Prof. Dong Wang in University of California, San Diego. 2010-2013.02 Postdoctoral with Prof. Xuhui Huang in Chemistry Department, Hong Kong University of Science and Technology.
研究领域
1. 计算机模拟生物大分子机器2. 天然产物生物合成机制及药物功能研究
近期论文
1. Lin-Tai Da*, Jin Yu Base-Flipping Dynamics from an Intrahelical to an Extrahelical State Exerted by Thymine DNA Glycosylase During DNA Repair Process. Nucleic Acids Research 2018 46, 5410-5425 (corresponding author). 2. Lin-Tai Da*, Yi Shi, Guodong Ning, Jin Yu*. Dynamics of the Excised Base Release in Thymine DNA Glycosylase during DNA Repair Process. Nucleic Acids Research 2018 46, 568-581 (corresponding author). 3. Lin-Tai Da*, Chao E, Yao Shuai, Shaogui Wu, Xiao-Dong Su, and Jin Yu*. T7 RNA polymerase translocation is facilitated by a helix opening on the fingers domain that may also prevent backtracking. Nucleic Acids Research 2017 45, 7909-7921 (corresponding author). 4. Lin-Tai Da, Fátima Pardo-Avila, Liang Xu, Daniel-Adriano Silva, Lu Zhang, Xin Gao, Dong Wang, Xuhui Huang. Bridge Helix Bending Promotes RNA Polymerase II Backtracking Through a Critical Threonine Residue. Nat. Commun. 2016 DOI: 10.1038/ncomms11244. 5. Lin-Tai Da, Chao E, Baogen Duan, Chuanbiao Zhang, Xin Zhou, Jin Yu. A Jump-from-Cavity Pyrophosphate Ion Release Assisted by a Key Lysine Residue in T7 RNA Polymerase Transcription Elongation. PLoS. Comp. Bio. 2015 11(11): e1004624. 6. Lin-Tai Da, Sheong, F.K., Silva, D., Huang, X. \
