个人简历

教授，研究生导师，山东农业大学“1512”工程第二层次。2014年毕业于山东大学动物学专业，获理学博士学位。2014-2020年在华中农业大学水产学院任教，2021年1月至今在山东农业大学动物科技学院工作。2017-2018年耶鲁大学访问学者。主持国家自然科学基金，湖北省重大项目子课题，湖北省面上项目，参与十三五“蓝色粮仓“等国家及省部级项目。以第一作者或通讯作者在Plos Pathogens， Journal of Virology，Molecular Immunology等杂志论文20余篇。

研究领域

""水生动物先天免疫，虾蟹主要病害的致病机制，疫苗研制及防控药物开发等。""""

近期论文

1. Liu Y, Zhang YH, Li T, Cao XT, Zhou Y, Yuan JF, Gu ZM, Lan JF*.PcLys-i3, an invertebrate lysozyme, is involved in the antibacterial immunity of the red swamp crayfish, Procambarus clarkii. Dev Comp Immunol. 2018 May 31;87:109-115.\r
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2. Qin Z, Babu VS, Wan Q, Zhou M, Liang R, Muhammad A, Zhao L, Li J, Lan J*, Lin L*. Transcriptome analysis of Pacific white shrimp (Litopenaeus vannamei) challenged by Vibrio parahaemolyticus reveals unique immune-related genes. Fish Shellfish Immunol. 2018 Mar 19. pii: S1050-4648. JCR 1区, IF=3.025.\r
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3. Qin Z, Babu VS, Wan Q, Muhammad A, Li J, Lan J*, Lin L*. Antibacterial activity of hemocyanin from red swamp crayfish (Procambarus clarkii). Fish Shellfish Immunol. 2018 Feb 7;75:391-399. JCR 1区, IF=3.025.\r
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4. Sun JJ#, Lan JF#, Zhao XF, Vasta N, Wang JX*, Binding of a C-type lectin's coiled-coil domain to the Domeless receptor directly activates the JAK/STAT pathway in the shrimp immune response to bacterial infection. PLoS Pathog. 2017 Sep 20;13(9):e1006626. doi: 10.1371/journal.ppat.1006626. JCR 1区， IF=6.608.\r
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5. Zhou J, Zhao S, Fang WH, Zhou JF, Zhang JX, Ma H, Lan JF*, Li XC*. Newly identified invertebrate-type lysozyme (Splys-i) in mud crab (Scylla paramamosain) exhibiting muramidase-deficient antimicrobial activity. Dev Comp Immunol. 2017 Sep;74:154-166. JCR1区， IF=3.62.\r
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6. Dai YJ#, Hui KM#, Zhang YH, Liu Y, Wang YQ, Zhao LJ, Lin L, Chai LQ*, Wei Shun*, Lan JF*. Three STATs are involved in the regulation of the expression of Antimicrobial peptides in the Triangle sail mussel, Hyriopsis cumingii. Fish Shellfish Immunol. 2017 Feb, 63: 181-188. JCR 1区, IF=3.025.\r
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7. Dai YJ, Wang YQ, Zhang YH, Liu Y, Li JQ, Wei S, Zhao LJ, Zhou YC, Lin L*, Lan JF*. The role of ficolin-like protein (PcFLP1) in the antibacterial immunity of red swamp crayfish (Procambarus clarkii). Mol Immunol., 2017, 81: 26-34. JCR 3区，IF=3.375.\r
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8. Lan JF, Zhao LJ, Wei S, Wang Y, Lin L, Li XC*. PcToll2 positively regulates the expression of antimicrobial peptides by promoting PcATF4 translocation into the nucleus. Fish Shellfish Immunol. 2016 Sep 10;58:59-66. JCR 1区, IF=3.025.\r
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9. Lan JF, Wei S, Wang YQ, Dai YJ, Tu JG, Zhao LJ, Li XC, Qin QW, Chen N*, Lin L*. PcToll3 was involved in anti-Vibrio response by regulating the expression of antimicrobial peptides in red swamp crayfish, Procambarus clarkii. Fish Shellfish Immunol, 2016 Aug 13, 57 : 17-24. JCR 1区, IF=3.025.\r
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10. Sun JJ, Lan JF*, Xu JD, Niu GJ, Wang JX*. Suppressor of cytokine signaling 2 negatively regulates the expression of antimicrobial peptides by affecting the Stat transcriptional activity in shrimp Marsupenaeus japonicus. Fish Shellfish Immunol. 2016 Aug 2;56:473-482. JCR 1区, IF=3.025.\r
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11. Wang Y, Chen N, Abeer M. Hegazy, Liu XD, Wu ZX , Liu XQ, Zhao LJ, Qin QW, Lan JF*, Lin L*. Autophagy induced by Snakehead fish vesiculovirus inhibited its replication in SSN-1 cell line. Fish Shellfish Immunol, 2016 Jun 13;55:415-422. JCR 1区, IF=3.025.\r
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12. Zhao LL, Wang YQ, Dai YJ, Zhao LJ, Qin QW, Lin L, Ren Q*, Lan JF*. A novel C-type lectin with four CRDs is involved in the regulation of antimicrobial peptide gene expression in Hyriopsis cumingii. Fish Shellfish Immunol, 2016 Jun 7;55:339-347. JCR 1区, IF=3.025.\r
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13. Zhao LL, Jin M, Li XC, Ren Q*, Lan JF*. Four C1q domain-containing proteins involved in the innate immune response in Hyriopsis cumingii. Fish Shellfish Immunol. 2016 Jun 7;55:323-331. JCR 1区, IF=3.025.\r
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14. Dai YJ, Wang YQ, Zhao LL, Qin ZD, Yuan JF, Qin QW, Lin L*, Lan JF*. A novel L-type lectin was required for the multiplication of WSSV in red swamp crayfish (Procambarus clakii). Fish Shellfish Immunol, 2016 May 18;55:48-55. JCR 1区, IF=3.025.\r
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15. Tu JG #, Chen WJ #, Fu XZ, Lin Q, Chang OQ, Zhao LJ, Lan JF*, Li NQ*, Lin L*.Susceptibility of Chinese perch brain (CPB) cell and Mandarin fish to Red-spotted grouper nervous necrosis virus (RGNNV) infection. Int J Mol Sci. 2016 May 19;17(5). pii: E740. JCR 3区， IF=3.257.\r
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16. Wang Z#, Chen YH#, Dai YJ#, Tan JM, Huang Y, Lan JF*, Qian Ren*.A novel vertebrates Toll-like receptor counterpart regulating the anti-microbial peptides expression in the freshwater crayfish, Procambarus clarkii. Fish Shellfish Immunol. 2015 Jan 5;43(1):219-229. JCR 1区, IF=3.025.\r
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17. Ding ZF#, Ren J#, Tan JM, Wang Z, Yin SW, Huang Y, Huang X, Wang W, Lan JF*, Qian Ren*.Characterization of two novel ADP ribosylation factors from giant freshwater prawn Macrobrachium rosenbergii and their responses to WSSV challenge.Dev Comp Immunol. 2015 Jan;48(1):204-9. JCR 1区，IF=3.62.\r
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18. Liu N#, Lan JF #, Sun JJ#, Jia WM, Zhao XF, Wang JX*.A novel crustin from Marsupenaeus japonicus promotes hemocyte phagocytosis. Dev Comp Immunol. 2014 Dec 3;49(2):313-322. JCR 1区，IF=3.62.\r
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19. Ren Q#*, Lan JF#, Zhong X#, Song XJ, Ma F, Hui KM,Wang W, Yu XQ*, Wang JX*. A novel Toll like receptor with two TIR domains (HcToll-2) is involved in regulation of antimicrobial peptide gene expression of Hyriopsis cumingii. Dev Comp Immunol. 2014 Jul;45(1):198-208. JCR 1区，IF=3.62.\r
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20. Zhu L#, Lan JF#, Huang YQ#, Zhang C, Zhou JF, Fang WH*, Yao XJ, Wang H, Li XC*. SpALF4: a newly identified anti-lipopolysaccharide factor from the mud crab Scylla paramamosain with broad spectrum antimicrobial activity. Fish and Shellfish Immunology. 2014 Jan;36(1):172-80. JCR 1区, IF=3.025.