个人简历

教育背景\r
2011.10-2015.03，日本九州大学药学府，创药科学专业，博士\r
2008.09-2011.06，山东大学药学院，药物化学专业，硕士\r
2004.09-2008.06，安徽医科大学药学院，药学专业，本科\r
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工作经历\r
2020.06-至今，山东大学微生物技术国家重点实验室（微生物技术研究院），教授\r
2019.05-2019.12，浙江工业大学绿色制药协同创新中心，校聘教授\r
2015.04-2019.03，日本东京大学理学府，特任研究员，日本学术振兴会（JSPS）外国人特别研究员

研究领域

"""""1.DNA编码非经典环肽库的生物法构建以及基于药物靶标的环肽筛选\r
2. 人工核酸用于基因损伤修复机制以及抗肿瘤潜在应用的探讨"

近期论文

Huilei Dong＃, Jinjing Li＃, Hongtan Liu, Shuaimin Lu, Junjie Wu, Youming Zhang, Yizhen Yin*, Yibing Zhao, Chuanliu Wu*. Design and Ribosomal Incorporation of Noncanonical Disulfide-Directing Motifs for the Development of Multicyclic Peptide Libraries.J. Am. Chem. Soc. 2022, 144, 5116–5125.\r
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Daisuke Hazama＃,Yizhen Yin＃, Yoji Murata*, Makoto Matsuda, Takeshi Okamoto, Daisuke Tanaka, Naohiro Terasaka, Jinxuan Zhao, Mariko Sakamoto, Yuka Kakuchi, Yasuyuki Saito, Takenori Kotani, Yoshihiro Nishimura, Atsushi Nakagawa, Hiroaki Suga*, Takashi Matozaki*. Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPα Interaction as a Potential Cancer Immunotherapy. Cell Chem. Biol. 2020, 27, 1181-1191. (Co-first author)\r
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Yizhen Yin, Nobuaki Ochi, Timothy W. Craven, David Baker, Nagio Takigawa, Hiroaki Suga*. De novo carborane-containing macrocyclic peptides targeting human EGFR.J. Am. Chem. Soc. 2019, 141, 19193–19197.\r
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Yizhen Yin＃, Qianran Fei＃, Weidong Liu, Zhuoru Li, Hiroaki Suga*, Chuanliu Wu*. Chemical and Ribosomal Synthesis of Topologically Controlled Bicyclic and Tricyclic Peptide Scaffolds Primed by Selenoether Formation.Angew. Chem. Int. Edit. 2019, 58, 4880-4885.\r
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Alex Vinogradov,Yizhen Yin, Hiroaki Suga*. Macrocyclic peptides as drug candidates: recent progress and remaining challenges.J. Am. Chem. Soc. 2019, 141, 4167-4181.\r
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Sayaka Imanishi, Takayuki Katoh,Yizhen Yin, Mituhiro Yamada, Marina Kawai, Hiroaki Suga*. In Vitro Selection of Macrocyclic D/L-Hybrid Peptides against Human EGFR.J. Am. Chem. Soc. 2021, 143, 5680–5684.\r
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Emiko Mihara, Satoshi Watanabe, Nasir K. Bashiruddin, Nozomi Nakamura, Kyoko Matoba, Yumi Sano, Rumit Maini,Yizhen Yin, Katsuya Sakai, Takao Arimori, Kunio Matsumoto, Hiroaki Suga*, Junichi Takagi*. Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins.Nat. Commun. 2021, 12, 1543.\r
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Yizhen Yin, Fener Chen*. Targeting human MutT homolog 1 (MTH1) for cancer eradication: current progress and perspectives. Acta Pharm. Sin. B, 2020, 10, 2259–2271.\r
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Changsheng Wu＃*,Yizhen Yin＃, Lele Zhu, Youming Zhang, Yue-Zhong Li*. Metagenomic sequencing-driven multidisciplinary approaches to shed light on the untapped microbial natural products.Drug Discov. Today 2022, 27, 730–742.\r
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Yahong Tan＃, Junjie Wu＃, Lulu Song, Mengmeng Zhang, Christopher John Hipolito, Changsheng Wu, Siyuan Wang*, Youming Zhang,Yizhen Yin*. Merging the Versatile Functionalities of Boronic Acid with Peptides.Int. J. Mol. Sci. 2021, 22, 12958.\r
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Jia-Qi Hu, Jing-Jing Wang, Yue-Lan Li, Li Zhuo, Ai Zhang, Hai-Yan Sui, Xiao-Ju Li, Tao Shen,Yizhen Yin, Zhi-Hong Wu, Wei Hu, Yue-Zhong Li*, Changsheng Wu*. Combining NMR-Based Metabolic Profiling and Genome Mining for the Accelerated Discovery of Archangiumide, an Allenic Macrolide from the Myxobacterium Archangium violaceum SDU8.Org. Lett. 2021, 23, 2114–2119.\r
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Yizhen Yin, Shigeki Sasaki, Yosuke Taniguchi*. Effects of 8-halo-7-deaza-2'-deoxyguanosine triphosphate on DNA synthesis by DNA polymerases and cell proliferation.Bioorg. Med. Chem. 2016, 24, 3856-3861.\r
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Yizhen Yin, Shigeki Sasaki, Yosuke Taniguchi*. Inhibitory Effect of 8-Halogenated-7-deaza-2'-deoxyguanosine Triphosphates on Human 8-Oxo-2'-deoxyguanosine Triphosphatase, hMTH1, Activities.ChemBioChem 2016, 17, 566-569.\r
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Yizhen Yin, Shigeki Sasaki, Yosuke Taniguchi*. Recognition and excision properties of 8-halogenated-7-deaza-2'-deoxyguanosine as 8-oxo-2'-deoxyguanosine analogues and Fpg and hOGG1 inhibitors. ChemBioChem 2015, 16, 1190-1198.\r
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Yizhen Yin, Yosuke Taniguchi*, Shigeki Sasaki*. Synthesis of 8-Halogenated-7-deaza-2'-deoxyguanosine as an 8-Oxo-2'-deoxyguanosine Analogue and Evaluation of its Base Pairing Properties.Tetrahedron 2014, 70, 2040-2047.\r
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Yizhen Yin, Chao Liu, Long-Qian Tang and Zhao-Peng Liu*. Recoverable Pd/C catalyst mediated dehydrogenation of sterols and an improved synthesis of 1α-hydroxydehydroepiandrosterone.Steroids 2012, 77, 1419–1422.\r
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Yizhen Yin, Jian-Ping Li, Chao Liu, Long-Qian Tang and Zhao-Peng Liu*. Advances in the Synthesis of A-Ring 1,7-Enyne Synthons for Active Vitamin D3 Analogues.Curr. Org. Synth. 2011, 8, 374-392.\r
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Bing-Lei Gao, Cheng-Mei Zhang,Yi-Zhen Yin, Long-Qian Tang, Zhao-Peng Liu*. Design and synthesis of potent HIV-1 protease inhibitors incorporating hydroxyprolinamides as novel P2 ligands.Bioorg. Med. Chem. Lett. 2011, 21, 3730-3733.