个人简历

教育背景\r
博士 起止时间：毕业院校：专业：1985-1989, 美国加州大学洛杉矶分校\r
硕士 起止时间：毕业院校：专业：1983-1984, 加拿大曼尼托巴大学\r
学士 起止时间：毕业院校：专业：1987-1982,山东大学\r
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工作经历\r
1992-1998 美国华盛顿州立大学 助理教授\r
1998-2004 美国华盛顿州立大学 副理教授\r
2004-今 美国华盛顿州立大学 教授\r
2012-今 山东大学 特聘教授

研究领域

"""""细菌硫代谢：包括代谢途径，硫循环，硫化氢及多硫化物对细菌基因表达的调控，碳循环的耦合，及硫化氢和含硫化合物的生物修复。\r
合成生物学：包括技术开发，机理研究，及在环境保护中的应用。"

近期论文

Hayes, R.P., A.R. Green, M.S. Nissen, K.M. Lewis, L. Xun*, C. Kang*. 2013. Structural characterization of 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA) from Sphingobium chlorophenolicum, a new type of aromatic ring-cleavage enzyme. Mol Microbiol. 88:523-536. doi: 10.1111/mmi.12204.\r
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Hayes R.P., K.M. Lewis, L. Xun*, and C. Kang*. 2013. Catalytic mechanism of 5-chlorohydroxyhydroquinone dehydrochlorinase from the YCII superfamily of largely unknown function. J Biol Chem. 288(40):28447-56. doi: 10.1074/jbc.M113.499368.Liu H., Y. Xin, and L. Xun*. 2014. Distribution, diversity and activities of sulfur dioxygenases in heterotrophic bacteria. Appl Environ Microbiol. 80:1799-1806. doi:10.1128/AEM.03281-13.\r
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Xia Y., W. Chu, Q. Qi, and L. Xun*. 2015. New insights into the QuikChangeTM process guide the use of Phusion DNA polymerase for site-directed mutagenesis. Nucleic Acids Res. 43(2):e12. doi: 10.1093/nar/gku1189.\r
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Sattler SA,X.Wang,K.M.Lewis,P.J.DeHan,C.M.Park,Y.Xin,H.Liu,M.Xian,L.Xun*, andC.Kang*. (2015) Characterizations of Two Bacterial Persulfide Dioxygenases of the Metallo-β-lactamase Superfamily. JBC 290. 18914-18923.\r
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Xin Y, Liu H, Cui F, Liu H, Xun L*. 2016. Recombinant Escherichia coli with sulfide: Quinone oxidoreductase and persulfide dioxygenase rapidly oxidizes sulfide to sulfite and thiosulfate via a new pathway. Environ Microbiol. 18:5123-5136.\r
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Xia Y, and Xun L*. 2017. Revised Mechanism and Improved Efficiency of the QuikChange Site-Directed Mutagenesis Method. Methods Mol Biol. 1498:367-374.\r
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Li H, Li J, Lü C, Xia Y, Xin Y, Liu H, Xun L*, Liu H*. 2017. FisR activatesσ54-dependenttranscription of sulfide-oxidizing genes inCupriavidus pinatubonensisJMP134. Mol Microbiol. 105:373-384. doi: 10.1111/mmi.13725.\r
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Lü C,Xia Y,Liu D, Zhao R, Gao R, Liu H, Xun L. 2017.Cupriavidus necator H16 uses flavocytochromec-sulfide dehydrogenase to oxidize self-produced and spiked sulfide.Appl Environ Microbiol.83:e01610-17. doi: 10.1128/AEM.01610-17.\r
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Xia Y, Lü C, Hou N, Xin Y, Liu J, Liu H*, Xun L*. 2017. Sulfide production and oxidation by heterotrophic bacteria under aerobic conditions. ISME J. 11:2754-2766. doi: 10.1038/ismej.2017.125.\r
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Gao R, Liu H,Xun L. 2017. Cytoplasmic Localization of Sulfide:Quinone Oxidoreductase and Persulfide Dioxygenase ofCupriavidus pinatubonensis JMP134. Appl Environ Microbiol. 83: e01820-17. doi: 10.1128/AEM.01820-17.