个人简历

教育背景\r
1999.9-2003.7，山东大学，生物技术学士\r
2003.9-2008.7，中科院上海药物研究所，药物设计博士\r
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工作经历\r
2008.8-2011.7，美国加州大学戴维斯分校，博士后\r
2011.8-2016.8，美国桑福德伯纳姆医学研究所，博士后\r
2016.9-至今，山东大学微生物技术研究院，教授

研究领域

""本课题组专注于研究重大疾病相关的靶标蛋白，如人体内的转录因子蛋白和病原微生物中的关键酶类等。\r
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一方面利用结构生物学和分子药理学等方法，研究这些蛋白的结构和功能，并揭示蛋白和配体的相互作用，以及配体调控蛋白活性的分子机理；另一方面通过设计和搭建多种化合物筛选体系，发现新的靶向小分子，并进一步通过计算模拟和结构改造等手段，获得活性更好的新药先导化合物""""

近期论文

Zhong L, Diao X, Zhang N, Li F, Zhou H, Chen H, Bai X, Ren X, Zhang Y*,Wu D*, Bian X*. Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis.Nat Commun.2020 (in press).（*共同通讯作者）\r
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Tie L*, Xiao H*,Wu D*, Yang Y, Wang P. A brief guide to good practices in pharmacological experiments: Western blotting.Acta Pharmacol Sin.2020 Oct 21.（*共同通讯作者）\r
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Dahlem C, Kado SY, He Y, Bein K,Wu D, Haarmann-Stemmann T, Kado NY, Vogel CFA. AHR signaling interacting with nutritional factors regulating the expression of markers in vascular inflammation and atherogenesis.Int J Mol Sci.2020, 21: 8287.\r
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Jiang K, Zhang Y, Chen Z,Wu D, Cai J, Gao X. Structural and functional insights into the C-terminal fragment of insecticidal Vip3A toxin of Bacillus thuringiensis.Toxins (Basel).2020, 12: 438.\r
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Xu M, Xu HH, Lin Y, Sun X, Wang LJ, Fang ZP, Su XH, Liang XJ, Hu Y, Liu ZM, Cheng Y, Wei Y, Li J, Li L, Liu HJ, Cheng Z, Tang N, Peng C, Li T, Liu T, Qiao L,Wu D, Ding YQ, Zhou WJ. LECT2, a ligand for Tie1, plays a crucial role in liver fibrogenesis.Cell. 2019, 178: 1478-1492.[获得F1000Prime推荐]\r
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Wu D*, Su X, Lu J, Li S, Hood BL, Vasile S, Potluri N, Diao X, Kim Y, Khorasanizadeh S, Rastinejad F*. Bidirectional modulation of HIF-2 activity through chemical ligands.Nat Chem Biol.2019, 15: 367-376. （*共同通讯作者）[获得F1000Prime推荐]\r
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Chandra V#,Wu D#, Li S, Potluri N, Kim Y, Rastinejad F. The quaternary architecture of RARβ-RXRα heterodimer facilitates domain-domain signal transmission.Nat Commun.2017, 8: 868.（#共同第一作者）\r
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Wu D, Rastinejad F. Structural characterization of mammalian bHLH-PAS transcription factors.Curr Opin Struct Biol.2017, 43: 1-9.\r
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Smith SH, Jayawickreme C, Rickard DJ, Nicodeme E, Bui T, Simmons C, Coquery CM, Neil J, Pryor WM, Mayhew D, Rajpal DK, Creech K, Furst S, Lee J,Wu D, Rastinejad F, Willson TM, Viviani F, Morris DC, Moore JT, Cote-Sierra J. Tapinarof is a natural AhR agonist that resolves skin inflammation in mice and humans.J Invest Dermatol.2017, 137: 2110-2119.\r
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Wu D, Su X, Potluri N, Kim Y, Rastinejad F. NPAS1-ARNT and NPAS3-ARNT crystal structures implicate the bHLH-PAS family as multi-ligand binding transcription factors.eLife.2016, 5: e18790.\r
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Vogel CF, Charrier JG,Wu D, McFall AS, Li W, Abid A, Kennedy IM, Anastasio C. Physicochemical properties of iron oxide nanoparticles that contribute to cellular ROS-dependent signaling and acellular production of hydroxyl radical.Free Radic Res.2016, 50: 1153-1164.\r
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Vogel CF, Chang WL, Kado S, McCulloh K, Vogel H,Wu D, Haarmann-Stemmann T, Yang G, Leung PS, Matsumura F, Gershwin ME. Transgenic overexpression of aryl hydrocarbon receptor repressor (AhRR) and AhR-mediated induction of CYP1A1, cytokines, and acute toxicity.Environ Health Perspect.2016, 124: 1071-1083.\r
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Wu D, Potluri N, Lu J, Kim Y, Rastinejad F. Structural integration in hypoxia-inducible factors.Nature.2015, 524: 303-308.[在Nature同期News&Views栏目中被特别介绍，并获得F1000Prime推荐]\r
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Vogel CF, Khan EM, Leung PS, Gershwin ME, Chang WL,Wu D, Haarmann-Stemmann T, Hoffmann A, Denison MS. Cross-talk between aryl hydrocarbon receptor and the inflammatory response: a role for nuclear factor-κB.J Biol Chem.2014, 289: 1866-1875.\r
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Wu D, Potluri N, Kim Y, Rastinejad F. Structure and dimerization properties of the aryl hydrocarbon receptor PAS-A domain.Mol Cell Biol.2013, 33: 4346-4356. [被编辑选为当期“意义显著”论文之一]\r
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Chandra V, Huang P, Potluri N,Wu D, Kim Y, Rastinejad F. Multidomain integration in the structure of the HNF-4α nuclear receptor complex.Nature.2013, 495: 394-398.\r
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Vogel CF,Wu D, Goth SR, Baek J, Lollies A, Domhardt R, Grindel A, Pessah IN. Aryl hydrocarbon receptor signaling regulates NF-κB RelB activation during dendritic-cell differentiation.Immunol Cell Biol.2013, 91: 568-575.\r
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Vogel CF, Garcia J,Wu D, Mitchell DC, Zhang Y, Kado NY, Wong P, Trujillo DA, Lollies A, Bennet D, Schenker MB, Mitloehner FM. Activation of inflammatory responses in human U937 macrophages by particulate matter collected from dairy farms: an in vitro expression analysis of pro-inflammatory markers.Environ Health.2012, 11: 17.\r
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Wu D#, Nishimura N#, Kuo V, Fiehn O, Shahbaz S, Van Winkle L, Matsumura F, Vogel CF. Activation of aryl hydrocarbon receptor induces vascular inflammation and promotes atherosclerosis in apolipoprotein E-/- mice.Arterioscler Thromb Vasc Biol.2011, 31: 1260-1267. （#共同第一作者）[被编辑在同期社论中推荐]\r
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Wu D, Wong P, Li W, Vogel CF, Matsumura F. Suppression of WIF-1 through promoter hypermethylation causes accelerated proliferation of the aryl hydrocarbon receptor (AHR) overexpressing MCF10AT1 breast cancer cells.Toxicology.2011, 285: 97-103.