个人简历

教育背景 博士: 1993.8-1996.12, University of Birmingham (UK), 细胞与分子生物学 硕士: 1986.9-1989.6, 兰州大学, 植物学 本科 1982.9-1986.6 兰州大学 植物学 工作经历 2003.11-现在:山东大学微生物技术国家重点实验室,教授,博导1999.4-2003.10:日本通产省产业技术综合研究所,研究员 1997.1-1999.3: 日本农水省果树研究所, 博士后（JST特别研究员） 1989.7-1993.8 中国农业科学院兰州畜牧研究所 助理研究员

研究领域

1. 极端嗜热古菌DNA修复机制 2. 硫化叶菌细胞分裂、病毒复制组装和外排及囊泡分泌机制 3. 极端环境微生物资源及极端酶

近期论文

1.Zhai B, DuPrez K, Han, H, Yuan Z, Ahmad S, Xu C, Gu L, Ni J, Fan L, Shen (2018) The archaeal ATPase PINA interacts with the helicase Hjm via its carboxyl terminal KH domain remodeling and processing replication fork and Holliday junction. Nucleic Acids Research. (accepted). 2. Liu J, Gao R, Li C, Ni J, Yang Z, Zhang Q, Chen H, Shen Y. (2017) Functional assignment of multiple ESCRT-III homologs in cell division and budding in Sulfolobus islandicus. Mol Microbiol. 105(4), 540–553. 3.Zhai B, DuPrez K, Doukov TI, Li H, Huang M, Shang G, Ni J, Gu L, Shen Y, Fan L. (2017) Structure and Function of a Novel ATPase that Interacts with Holliday Junction Resolvase Hjc and Promotes Branch Migration. J Mol Biol. 7;429(7):1009-1029. 4. Huang Q, Zhong Q, Mayaka J, Ni J, Shen Y (2017) Autophosphorylation and Cross-phosphorylation of Protein Kinases from the Crenarchaeon Sulfolobus islandicus. Frontiers in Microbiology, 8: 2173 5.Huang Q, Li Y, Zeng C, Song T, Yan Z, Ni J, She Q, Shen Y (2015) Genetic analysis of the Holliday junction resolvases Hje and Hjc in Sulfolobus islandicus. Extremophiles. 19:505-14. 6. Zheng T, Huang H, Zhang C, Ni J, She Q, Shen Y (2012) Development of simvastatin selection marker for hyperthermophilic acidophile, Applied. Environ. Microbiol. 78:568-574. 7. Hong Y, Chu M, Li Y, Ni J, Sheng D, Hou G, She Q, Shen Y (2012) Dissection of the functional domains of an archaeal Holliday junction helicase, DNA Repair. 11:102-111. 8. Li Z, Lu S, Hou G, Ma X, Sheng D, Ni J & Shen Y (2008) Hjm/Hel308a DNA helicase fromSulfolobus tokodaiipromotes replication fork regression and interacts with Hjc endonuclease in vitro. J Bacteriol. 190: 3006–17. 9. Shen, Y., Tang X.-F., Yokoyama H., Matsui E., and Matsui I. (2004) A 21-aa peptide from the cysteine cluster II of the family D DNA polymerase from Pyrococcushorikoshii stimulates its nuclease activity which is Mre11-like and prefers manganese ion as the co-factor. Nucleic Acids Research. 32: 158-168. 10.Shen Y, Tang XF, Matsui I. (2003) Subunit interaction and regulation of activity through terminal domains of the family D DNA polymerase from Pyrococcus horikoshii. J Biol Chem. 278(23):21247-57.