个人简历

教育背景 博士 2010.10-2014.12 格罗宁根大学 专业：微生物生理 硕士 2007.09-2010.07 山东大学 专业：微生物 学士 2003.09-2007.07 山东大学 专业：生物技术（生命科学基地） 工作经历 起止时间 单位名称 专业技术职务 2016.12-现在 山东大学微生物技术研究院 副研究员 2015.1-2016.12 格罗宁根大学 博士后

研究领域

糖苷水解酶的结构和功能 多糖和寡糖的酶法合成 肠道微生物的分离培养 肠道微生物的定植和稳态维持机制 肠道微生物对外源物质的代谢

近期论文

Wang L, Zheng F, Zhang W, Zhong Y, Chen G,Meng X*，Liu W (2018)A copper-controlled RNA interference system for reversible silencing of target genes in Trichoderma reesei. Biotechnol Biofuels 11: 33.(*Corresponding author) Wang Z,An N,Xu W,Zhang W,Meng X*,Chen G,Liu W*. (2018)Functional characterization of the upstream components of the Hog1-like kinase cascade in hyperosmotic and carbon sensing in Trichoderma reesei.Biotechnol Biofuels11: 97.(Co-corresponding author). Meng X, Gangoiti J, Bai Y, Pijning T, van Leeuwen SS, Dijkhuizen L (2016)Structure-function relationships of family GH70 glucansucrase and 4,6-α-glucanotransferase enzymes, and their evolutionary relationships with family GH13 enzymes.Cell Mol Life Sci, 73(14):2681-706. Meng X, Pijning T, Dobruchowska JM, Gerwig GJ, Dijkhuizen L (2015)Characterization of the functional roles of amino acid residues in acceptor binding subsite +1 in the active site of the glucansucrase GTF180 enzyme ofLactobacillus reuteri180.J Biol Chem, 290 (50): 30131-30141. Meng X, Dobruchowska JM, Pijning T, López CA, Kamerling JP, Dijkhuizen L (2014)Residue Leu940has a crucial role in the linkage and reaction specificity of the glucansucrase GTF180 of the probiotic bacteriumLactobacillus reuteri180. J Biol Chem, 289 (47):32773-32782. Meng X, Dobruchowska JM, Pijning T, Gerwig GJ, Kamerling JP, Dijkhuizen L (2015) Truncation of domain V of the multidomain glucansucrase GTF180 ofLactobacillus reuteri180 heavily impairs its polysaccharide-synthesizing ability. Appl Microbiol Biotechnol, 99 (14):5885-5894. Meng X, Dobruchowska JM, Pijning T, Gerwig GJ, Dijkhuizen L (2016) Synthesis of new hyper-branched α-glucans from sucrose byLactobacillus reuteri180 glucansucrase mutants. J Agric Food Chem, 64 (2), 433–442. Meng X, Dobruchowska JM, Gerwig GJ, Kamerling JP, Dijkhuizen L (2015) Synthesis of oligo- and polysaccharides byLactobacillus reuteri121 reuteransucrase at high concentrations of sucrose. Carbohydr Res, 414:85-92. Meng X, Pijning T, Dobruchowska JM, Gerwig GJ, Kamerling JP & Dijkhuizen L (2016) Structural determiants of alternating (α1→4) and (α1→6) linkage specificity in reuteransucrase ofLactobacillus reuteri. Sci Rep 6:35261 Meng X, Pijning T, Kralj S, Gerwig GJ, Kamerling JP & Dijkhuizen L (2017) Characterization of the glucansucrase GTF180 W1065 mutant enzymes producing polysaccharides and oligosaccharides with altered linkage specificity.Food Chemistry,217:81-90 . Meng X,Gangoiti J,de Kok N,van Leeuwen SS, Pijning T, Dijkhuizen L (2018)Biochemical characterization of two GH70 family 4,6-α-glucanotransferases with distinct product specificity fromLactobacillus aviarius subsp. aviariusDSM 20655.Food Chemistry,253:236-246