个人简历

学习经历 2000/09至2003/07，中国海洋大学，医药学院，博士研究生/博士 1997/09至2000/07，山东大学，生命科学院，硕士研究生/硕士 1992/09至1996/07，中南民族大学，化学系，本科/学士 研究经历 2011/06至今，山东大学，国家糖工程技术研究中心，教授，博士生导师，泰山产业领军人才 2007/02至2011/06，加拿大多伦多大学，分子细胞生物学部，博士后，导师Jorge Filmus 教授 2006/04至2007/01，日本北海道大学，生命科学研究生院，博士后，导师Kazuyuki Sugahara 教授 2003/10至2006/04，日本神户药科大学，生物化学系，日本学术振兴学会(JSPS)博士后，导师Kazuyuki Sugahara 教授

研究领域

""（1）海洋微生物来源新型多糖特别是糖胺聚糖降解酶的资源开发、催化机制研究、分子酶学改造与应用；\r
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（2）糖胺聚糖构效关系研究及相关医药产品的研发；\r
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（3）基于新型酶和探针的糖相关新型分析检测技术研发和应用；\r
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（4）细胞表面蛋白聚糖在胚胎发育和癌变过程中的细胞信号转导调控机制研究.""""

近期论文

Chune Peng, Qingbin Wang, Shumin Wang, Wenshuang Wang, Runmiao Jiao, Wenjun Han, and Fuchuan Li*. A chondroitin sulfate and hyaluronic acid lyase with poor activity to glucuronyl 4,6-O-disulfated N-acetylgalactosamine (E-type)-containing structures. J. Biol. Chem. 2018, 293(12):4230-4243. Chune Peng, Qingbin Wang, Danrong Lu, Wenjun Han, and Fuchuan Li*. A Novel Bifunctional Endolytic Alginate Lyase with Variable Alginate-Degrading Modes and Versatile Monosaccharide-Producing Properties. Front. Microbiol. 2018, 9:167. Naihan Han, Wenshuang Wang, Danrong Lu, Han Wang, Xinying Ma, Xiaopeng Fan, and Fuchuan Li*. A novel, rapid, and sensitive homogeneous sandwich detection method of Glypican-3 as a serum marker for hepatocellular carcinoma. Chem. Commun (Camb)., 2017, 53(90):12209-12212. Wenshuang Wang, Xiaojuan Cai, Naihan Han, Wenjun Han, Kazuyuki Sugahara, and Fuchuan Li*. Sequencing of chondroitin sulfate oligosaccharides using a novel exolyase from a marine bacterium that degrades hyaluronan and chondroitin sulfate/dermatan sulfate. Biochem. J., 2017, 474(22):3831-3848. Wenshuang Wang, Junhong Wang, and Fuchuan Li*. Hyaluronidase and Chondroitinase. Adv. Exp. Med. Biol., 2017, 925:75-87. Invited review. Shumin Wang, Kazuyuki Sugahara, and Fuchuan Li*. Chondroitin sulfate/dermatan sulfate sulfatases from mammals and bacteria. Glycoconj. J., 2016, 33(6):841-851. Invited Review. Xiaoru Zhang, Ruijuan Li, Yuanyuan Chen, Shusheng Zhang, Wenshuang Wang, and Fuchuan Li*. Applying DNA rolling circle amplification in fluorescence imaging of cell surface glycans labeled by a metabolic method. Chem. Sci., 2016, 7, 6182-6189. Wenjun Han, Yuanyuan Cheng, Dandan Wang, Shumin Wang, Huihui Liu, Jingyan Gu, Zhihong Wu, and Fuchuan Li *. Biochemical Characteristics and Substrate Degradation Pattern of a Novel Exo-Type β-Agarase from the Polysaccharide-Degrading Marine Bacterium Flammeovirga sp. Strain MY04. Appl. Environ. Microbiol. 2016, pii: AEM.00393-16. Wenjun Han, Jingyan Gu, Yuanyuan Cheng, Huihui Liu, Yuezhong Li, and Fuchuan Li*. Novel Alginate Lyase (Aly5) from a Polysaccharide-Degrading Marine Bacterium, Flammeovirga sp. Strain MY04: Effects of Module Truncation on Biochemical Characteristics, Alginate Degradation Patterns, and Oligosaccharide-Yielding Properties. Appl. Environ. Microbiol. 2015, 82(1):364-74. Wenshuang Wang, Naihan Han, Ruijuan Li, Wenjun Han, Xiaoru Zhang, and Fuchuan Li*. Supercharged Fluorescent Protein as a Versatile Probe for the Detection of Glycosaminoglycans in Vitro and in Vivo. Anal. Chem. 2015, 87(18):9302-7. Wenshuang Wang, Wenjun Han, Xingya Cai, Xiaoyu Zheng, Kazuyuki Sugahara, and Fuchuan Li*. Cloning and characterization of a novel chondroitin sulfate/dermatan sulfate 4-O-endosulfatase from a marine bacterium. J. Biol. Chem. 2015, 290(12):7823-32. Wenjun Han, Wenshuang Wang, Mei Zhao, Kazuyuki Sugahara, and Fuchuan Li*. A novel eliminase from a marine bacterium that degrades hyaluronan and chondroitin sulfate. J. Biol. Chem. 2014, 289(40):27886-98. Fuchuan Li, Wen Shi, Mariana I Capurro and Jorge Filmus. Glypican-5 stimulates rhabdomyosarcoma cell proliferation by activating hedgehog signaling. (2011) J. Cell Biol., 192(4):691-704. Fuchuan Li, Chilkunda D. Nandini, Tomohide Hattori, Xingfeng Bao, Daisuke Murayama, Toshikazu Nakamura, Nobuhiro Fukushima, and Kazuyuki Sugahara. Structure of pleiotrophin- and hepatocyte growth factor-binding sulfated hexasaccharide determined by biochemical and computational approaches. (2010) J. Biol. Chem., 285(36):27673-85. Mariana I Capurro, Fuchuan Li and Jorge Filmus. Overgrowth of a mouse model of Simpson-Golabi-Behmel syndrome is partly mediated by Indian hedgehog. (2009) EMBO Rep., 10(8):901-7. Fuchuan Li, Gerdy B. ten Dam, Sengottuvelan Murugan, Shuhei Yamada, Taishi Hashiguchi, Shuji Mizumoto, Kayoko Oguri, Minoru Okayama, Toin H. van Kuppevelt, and Kazuyuki Sugahara. Involvement of Highly Sulfated Chondroitin Sulfate in the Metastasis of the Lewis Lung Carcinoma Cells. (2008) J. Biol. Chem., 283(49):34294-304. Mariana I Capurro, Ping Xu, Wen Shi, Fuchuan Li, Angela Jia and Jorge Filmus. Glypican-3 Inhibits Hedgehog Signaling During Development by Competing with Patched for Hedgehog Binding. (2008) Dev. Cell, 14(5):700-11. Fuchuan Li, Ajaya Kumar Shetty and Kazuyuki Sugahara. Neuritogenic activity of chondroitin/dermatan sulfate hybrid chains of embryonic pig brain and their mimicry from shark liver. Involvement of the pleiotrophin and hepatocyte growth factor signaling pathways. (2007) J. Biol. Chem., 282(5): 2956-2966.