个人简历

教育背景\r
博士：2004.09-2009.12，美国密西根大学药学院，药物化学系\r
硕士：2000.09-2003.07，厦门大学生命科学学院，微生物与生物技术系\r
学士：1996.09-2000.07，厦门大学生命科学学院，生物学基地班\r
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工作经历 \r
起止时间 单位名称 专业技术职务\r
2018.11至今，微生物技术国家重点实验室，山东大学，教授\r
2012.06-2018.10，中国科学院青岛生物能源与过程研究所，研究员\r
2010.01-2012.05，美国密西根大学生命科学学院，博士后；参与创立生物技术公司Alluvium Biosciences Inc.，并担任生化部总监\r
2003.09-2004.08，厦门大学生命科学学院，研究助理

研究领域

""1.微生物天然产物生物合成\r
2. P450酶学与酶工程\r
3.工业微生物菌株改良""""

近期论文

Ye, Y. #, Du, L. #, Zhang, X.,Newmister, S. A.,McCauley, M.,Alegre-Requena, J. V., Zhang, W., Mu, S.,Minami, A.,Fraley, A. E.,Adrover-Castellano, M. L.,Carney, N. A., Shende, V. V., Qi, F.,Oikawa, H., Kato, H.,Tsukamoto, S., Paton, R. S.,Williams, R. M.*, Sherman, D. H.*, andLi, S.* Fungal-derived Brevianamide assembly by a stereoselective semi-pinacolase.Nat. Catal.(Accepted)\r
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Li, S.*, Du, L., and Bernhardt, R.* Redox partners: Function modulators of bacterial P450 enzymes.Trends Microbiol. 2020, doi.org/10.1016/j.tim.2020.02.012.\r
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Jiang, Y., Li, Z., Zheng, S., Xu, H., Zhou, Y. J., Gao, Z., Meng, C. *, andLi, S.* Establishing an enzyme cascade for one-pot production of α-olefns from low-cost triglycerides and oils without exogenous H2O2 addition.Biotechnol. Biofuels 2020, 13, 52.\r
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Xu, H., Liang, W., Ning, L., Jiang, Y., Yang, W., Wang, C., Qi, F., Ma, L., Du, L., Fourage, L., Zhou, Y. J. andLi, S.* Directed Evolution of P450 Fatty Acid Decarboxylases via High-Throughput Screening towards Improved Catalytic Activity.ChemCatChem 2019, 11, 1-6..\r
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Liu, K., andLi, S.* Biosynthesis of fatty acid derived hydrocarbons: perspectives on enzymology and enzyme engineering,Curr. Opin. Biotech.2019, 62, 7-14.\r
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Zhang, W., Du, L., Qu, Z., Zhang, X., Li, F., Li, Z., Qi, F., Wang, X., Jiang, Y., Men, P., Sun, J., Cao, S., Geng, C., Qi, F., Wan, X., Liu, C., andLi, S.* Compartmentalized Biosynthesis of Mycophenolic Acid.Proc. Natl. Acad. Sci. U.S.A. 2019, 116(27), 13305-13310.\r
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Jiang, Y., Li, Z., Wang, C., Zhou, Y. J., Xu, H.*, andLi, S.*Biochemical characterization of three newα-olefn-producing P450 fatty acid decarboxylases with a halophilic property.Biotechnol. Biofuels 2019, 12, 79.\r
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Zhang, W. #, Du, L. #, Li, F., Zhang, X., Qu, Z., Han, L., Li, Z., Sun, J., Qi, F., Yao, Q., Sun, Y., Geng, C.,Li, S.* Mechanistic insights into interactions between bacterial class I P450 enzymes and redox partners.ACS Catal. 2018, 8, 9992-10003.\r
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Jiang, Y.,Li, S.* The catalytic function and application of cytochrome P450 enzymes in biosynthesis and organic synthesis.Chin. J. Org. Chem. 2018,38(9), 2307-2323.\r
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Qi, F. #, Lei, C. #, Li, F., Zhang, X., Wang, J., Zhang, W., Fan, Z., Li, W., Tang, G., Xiao, Y.*, Zhao, G.,Li, S. * Deciphering the late steps of rifamycin biosynthesis.Nat. Commun.2018, 9,2342.\r
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Chen, H., Meng, X., Xu, X., Liu, W.,Li, S. *The molecular basis for lipase stereoselectivity.Appl. Microbiol. Biotechnol. 2018,102(8),3487-3495.\r
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Xu, H., Ning, L., Yang, W., Fang, B., Wang, C., Wang, Y., Xu, J., Colin, S., Laeuffer, F., Fourage, L., andLi, S. * In vitrooxidative decarboxylation of free fatty acids to terminal alkenes by two new P450 peroxygenases.Biotechnol. Biofuels2017, 10,208.\r
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Zhang, X., andLi, S.* Expansion of chemical space for natural products by uncommon P450 reactions.Nat. Prod. Rep. 2017, 34(9), 1061-1089.\r
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Du, L. #, Dong, S. #, Zhang, X., Jiang, C., Chen, J., Yao, L., Wang, X., Wan, X., Liu, X., Wang, X., Huang, S., Cui, Q., Feng, Y. *, Liu, S.*, andLi, S.*Selective oxidation of aliphatic C–H bonds in alkylphenols by a chemomimetic biocatalytic system.Proc. Natl. Acad. Sci. U.S.A. 2017,114(26), E5129-E5137.\r
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Li, Z., Du, L., Zhang, W., Zhang, X., Jiang, Y., Liu, K., Men, P., Xu, H., Fortman, J. L., Sherman, D. H., Yu, B., Gao, S.,Li, S.* Complete elucidation of the late steps of bafilomycin bios ynthesis inStreptomyces lohii.J. Biol. Chem. 2017,292(17), 7095-7104.\r
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Fang, B. #, Xu, H. #, Liu, Y., Qi, F., Zhang, W., Chen, H., Wang, C., Wang, Y., Yang, W., andLi, S.* Mutagenesis and redox partners analysis of the P450 fatty acid decarboxylase OleTJE.Sci. Rep.2017, 7, 44258.\r
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Sun, Y. #, Ma, L. #, Han, D. #, Du, L., Qi, F., Zhang, W., Sun, J., Huang, S., Kim, E.-S.,* andLi, S.* In vitro reconstitution of the cyclosporine specific P450 hydroxylases using heterologous redox partner proteins. J. Ind. Microbiol. Biotechnol.2016, 44(2),161-166.\r
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Zhang, X., Li, Z., Du, L., Chlipala, G. E., Lopez, P. C., Zhang, W., Sherman, D. H.*, andLi, S.* Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis.Tetrahedron Lett. 2016, 57(52), 5919-5923.\r
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Zheng, X., Fang, B., Han, D., Yang, W., Qi,F., Chen, H., andLi, S.* Improving the Secretory Expression of an α-Galactosidase fromAspergillus niger in Pichia pastoris.PLoS ONE 2016,11(8), e0161529.\r
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Du, L., Ma, L., Qi, F., Zheng, X., Jiang, C., Li, A., Wan, X., Liu, S.-J.*, andLi, S.* Characterization of a unique pathway for 4-cresol catabolism initiated by phosphorylation inCorynebacterium glutamicum. J. Biol. Chem. 2016, 291(12), 6583-6594.