个人简历

教育背景 博士 起止时间：1990-1993，毕业院校：山东大学，专业：微生物学 硕士 起止时间：1987-1990，毕业院校：山东农业大学，专业：真菌学 学士 起止时间：1983-1987，毕业院校：山东大学，专业：微生物学 工作经历 起止时间 单位名称 专业技术职务 1993-1995 中科院沈阳应用生态所 博士后 1995-2000 山东大学微生物技术国家重点实验室 副教授 1996.4-1996.10 德国国家生物技术研究中心（GBF） 高级访问学者 2000-今 山东大学微生物技术国家重点实验室 教授

研究领域

1、粘细菌多样性及其生态功能 2、粘细菌基因组中重要基因的重复及其功能机制 3、粘细菌产生的抗肿瘤化合物埃博霉素及其生物合成改造

近期论文

1、 XJ Yue, XW Cui, Z Zhang, WF Hu, ZF Li, YM Zhang and YZ Li*. Effects of transcriptional mode on promoter substitution and tandem engineering for the production of epothilones in Myxococcus xanthus. Appl Microbiol Biotechnol. (2018) doi.org/10.1007/s00253-018-9023-4 2、 R Peng, Y Wang, WW Feng, XJ Yue, JH Chen, XZ Hu, ZF Li, DH Sheng, YM Zhang and YZ Li*. CRISPR/dCas9‑mediated transcriptional improvement of the biosynthetic gene cluster for the epothilone production in Myxococcus xanthus. Microb Cell Fact (2018) 17:15. 3、 L Zhuo, Y Wang, Z Zhang, J Li, XH Zhang, YZ Li*. Myxococcus xanthus DK1622 coordinates expressions of the duplicate groEL and single groES genes for synergistic functions of GroELs and GroES. Frontiers in Microbiology (2017) 8: 733. 4、 R Peng, JH Chen, WW Feng, Z Zhang, J Yin, ZS Li, YZ Li*. Error-prone DnaE2 balances the genome mutation rates in Myxococcus xanthus DK1622. Frontiers in Microbiology (2017) 8: 122. 5、 XJ Yue, XW Cui, Z Zhang, R Peng, P Zhang, ZF Li, YZ Li*. A bacterial negative transcription regulator binding on an inverted repeat in the promoter for epothilone biosynthesis. Microbial Cell Factories (2017) 16: 92. 6、 YJ Yang, Y Wang, ZF Li, Y Gong, P Zhang, WC Hu, DH Sheng and YZ Li*. Increasing on target cleavage efficiency for CRISPR/Cas9 induced large fragment deletion in Myxococcus Xanthus. Microb Cell Fact (2017) 16:142. 7、 XJ Chen, K Han, J Feng, YZ Li*. The complete genome sequence and analysis of a plasmid-bearing myxobacterial strain Myxococcus fulvus 124B02. Standards in Genomic Sciences. (2016)11:1. 8、 LP Zhu, XJ Yue, K Han, ZF Li, LS Zheng, XN Yi, HL Wang, YM Zhang and YZ Li*. Allopatric integrations selectively change host transcriptomes, leading to varied expression efficiencies of exotic genes in Myxococcus xanthus. Microb Cell Fact (2015) 14:105. 9、 Y Wang, YZ Li*. Cultivation to improve in vivo solubility of overexpressed arginine deiminases in Escherichia coli and the enzyme characteristics. BMC biotechnology (2014) 14: 53. 10、 Y Wang, X Li, W Zhang, X Zhou, YZ Li*. groEL2, but not groEL1, is required for the biosynthesis of the secondary metabolite myxovirescin in Myxococcus xanthus DK1622. Microbiology (2014) 160, 488-495. 11、 SG Li, L Zhao, K Han, PF Li, ZF Li, H Liu, ZH Wu, YZ Li*. Diversity of epothilone producers among Sorangium strains in producer-positive soil habitats. Microb Biotechnol (2014) 7(2), 130-141. 12、 XW Zhou, SG Li, W Li, DM Jiang, K Han, ZH Wu and YZ Li*. Myxobacterial community is a predominant and highly diverse bacterial group in soil niches. Env Microbiol Rep (2014) 6(1):45-56. 13、 PY Zhang, PP Xu, ZJ Xia, J Wang, J Xiong and YZ Li*. Combined treatment with the antibiotics kanamycin and streptomycin promotes the conjugation of Escherichia coli. FEMS Microbiol Lett (2014) 348: 149–156. 14、 K Han, ZF Li, R Peng, LP Zhu, T Zhou, LG Wang, SG Li, XB Zhang, W Hu, ZH Wu, N Qin and YZ Li*. Extraordinary expansion of a Sorangium cellulosum genome from an alkaline milieu. Sci Rep (2013) 3, 2101. 15、 PF Li, SG Li, ZF Li, L Zhao, T Wang, HW Pan, H Liu, ZH Wu and YZ Li*. Co-cultivation of Sorangium cellulosum strains affects cellular growth and biosynthesis of secondary metabolite epothilones. FEMS Microbiol Ecol (2013) 85, 358-368. 16、 WJ Han, JY Gu, HH Liu, FC Li, ZH Wu, YZ Li*. An extra peptide within the catalytic module of a beta-agarase affects the agarose degradation pattern. J Biol Chem (2013) 288(13): 9519–9531. 17、 Y Wang, WY Zhang, Z Zhang, J Li, ZF Li, ZG Tan, TT Zhang, ZH Wu, H Liu, YZ Li*. Mechanisms involved in the functional divergence of duplicated GroEL chaperonins in Myxococcus xanthus DK1622. PLoS Genet (2013) 9(2): e1003306. 18、 J Feng, XJ Chen, X Sun, N Wang, YZ Li*: Characterization of the replication origin of the myxobacterial self-replicative plasmid pMF1. Plasmid (2012) 68: 105–112.