个人简历

教育背景 博士 起止时间：1994.9-2000.7 毕业院校：华中农业大学 专业：生化与分子生物学 硕士 起止时间：1994.9-1997.7 毕业院校：山东大学 专业：微生物学 学士 起止时间：1990.9-1994.7 毕业院校：山东大学 专业：微生物工程 工作经历 起止时间 单位名称 专业技术职务 2001.3-2003.8 德国马普学会化学生态所 博士后 2003.10-2005.10 日本东京大学 博士后 2005.12-2014.3 华中师范大学 副教授 2014.4-至今 山东大学 副教授

研究领域

1.天然产物的生物合成机制及药物创新 2.极端环境微生物的基因资源利用

近期论文

Liu Y, Liu S, Yang T, Guo X, Jiang Y, Zahid KR, Liu K, Liu J, Yang J, Zhao H, Yang Y, Li A*, Qi C*.(2015) Expression, crystallization and preliminary X-ray diffraction analyses of Med-ORF10 in the biosynthetic pathway of an antitumor antibiotic medermycin. The Protein Journal,34(6):404-410 He Q, Li L, Yang T, Li R, Li A1*(2015). Functional characterization of a ketoreductase-encoding gene med-ORF12 involved in the formation of a stereospecific pyran ring during the biosynthesis of an antitumor antibiotic medermycin. PLoS ONE. 10(7): e0132431 Lü J, He Q, Huang L, Cai X, Guo W, He J, Zhang L, Li A*(2015). Accumulation of a bioactive benzoisochromanequinone compound kalafungin by a wild type antitumor-medermycin-producing streptomycete strain. PLoS One. 10(2):e0117690 Lü J, Wu X, Jiang Y, Cai X, Huang L, Yang Y, Wang H, Zeng A and Li A *(2014). An extremophile Microbacterium strain and its protease production under alkaline conditions. Journal of Basic Microbiology. . 54(5):378-385 Deng H, Cai X, Peng J, Hong H, Ichinose K, Li A *(2010). Practical procedures for genetic manipulation systems for medermycin-producing Streptomyces sp. AM-7161. Journal of Basic Microbiology, 50(3): 299-301 Wang H, Li Z, Jia R, Yin J, Li A, Xia L, Yin Y, Müller R, Fu J*, Stewart AF*, Zhang Y*.(2018)ExoCET: exonuclease in vitro assembly combined with RecET recombination for highly efficient direct DNA cloning from complex genomes. Nucleic Acids Research. 16;46(5):2697 Wang H, Li Z, Jia R, Hou Y, Yin J, Bian X, Li A, Müller R, Stewart A F, Fu J*, Zhang Y*.(2016) RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression. Nature Protocols, 11:1175-79 Li A, J Piel (2002). A gene cluster from a marine Streptomyces encoding the biosynthesis of the spiroketal polyketide griseorhodin A. Chemistry & Biology. 9: 1017-1026 Zhou X#, He X#, Li A# (并列第一), Lei F, Kieser T, Deng Z (2004). Streptomyces coelicolor A3(2) lacks a genomic island present in the chromosome of Streptomyces lividans 66. Applied & Environmental Microbiology. 70(12): 7110-7118 Li A, Itoh T, Taguchi T, Xiang T, Ebizuka Y, Ichinose K (2005). Functional studies on a ketoreductase gene from Streptomyces sp. AM-7161 to control the stereochemistry in medermycin biosynthesis. Bioorganic & Medicinal Chemistry. 13: 6856-6863