个人简历

教育背景 德国萨尔大学/亥姆霍兹药物研究所，药物生物技术，博士学位 德国萨尔大学/亥姆霍兹药物研究所，药物生物技术，硕士学位 天津大学，生物工程，学士学位 研究工作经历 2017.10-至今，“齐鲁青年学者”特聘教授，微生物技术国家重点实验室，生命科学学院，山东大学 2014.09-2017.09,博士后，美国伊利诺伊大学香槟分校化学系

研究领域

1.微生物天然产物的生物合成2.合成生物学改造优化微生物天然产物合成3.基因组挖掘发现新型微生物天然产物

近期论文

1. Liujie Huo, Joachim J. Hug, Chengzhang Fu, Xiaoying Bian*, Youming Zhang*, Rolf Müller*. Heterologous expression of bacterial natural product biosynthetic pathways, Natural Product Reports, 2019, DOI: 10.1039/c8np00091c 2.Quade, N.*,Huo, L. * (co-first author), Rachid, S., Heinz, D.W., and Müller, R. (2012). Unusual carbon fixation gives rise to diverse polyketide extender units.Nat. Chem. Biol.8, 117-124. 3..Huo, L., Rachid, S., Stadler, M., Wenzel, S.C., and Müller, R. (2012). Synthetic biotechnology to study and engineer ribosomal bottromycin biosynthesis.Chem. Biol.19, 1278-1287. 4.Huo, L., and van der Donk, W.A. (2016). Discovery and Characterization of Bicereucin, an Unusual d-Amino Acid-Containing Mixed Two-Component Lantibiotic.J. Am. Chem. Soc.138, 5254-5257. 5.Huo, L., Ökesli, A., Zhao, M., and van der Donk, W.A. (2017). Insights into the Biosynthesis of Duramycin.Appl. Environ. Microbiol.83. 6.Mukherjee, S.,Huo, L., Thibodeaux, G.N., and van der Donk, W.A. (2016). Synthesis and Bioactivity of Diastereomers of the Virulence Lanthipeptide Cytolysin.Org. Lett.18, 6188-6191. 7.Mann, G.*,Huo, L. * (co-first author), Adam, S., Nardone, B., Vendome, J., Westwood, N.J., Müller, R., and Koehnke, J. (2016). Structure and Substrate Recognition of the Bottromycin Maturation Enzyme BotP.Chembiochem17, 2286-2292. 8.Gemperlein, K., Hoffmann, M.,Huo, L., Pilak, P., Petzke, L., Müller, R., and Wenzel, S.C. (2017). Synthetic biology approaches to establish a heterologous production system for coronatines.Metab. Eng.44, 213-222. 9.Silvia C Bobeica#, Shihui Dong#, Liujie Huo, Nuria Mazo, Martin Irving Harrison McLaughlin, Gonzalo Jimenez-Oses, Satish K Nair, Wilfred A van der Donk*, Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease, eLife, 2019, 8:e42305. 10.Rachid, S.,Huo, L., Herrmann, J., Stadler, M., Kopcke, B., Bitzer, J., and Müller, R. (2011). Mining the cinnabaramide biosynthetic pathway to generate novel proteasome inhibitors.Chembiochem12, 922-931. 11.Barbie, P.,Huo, L., Müller, R., and Kazmaier, U. (2012). Stereoselective synthesis of deuterium-labeled (2S)-cyclohexenyl alanines, biosynthetic intermediates of cinnabaramide.Org. Lett.14, 6064-6067.