个人简历

2013.07 —至今 山东大学药学院天然药物化学研究所 讲师
2008.09 —2013.06 山东大学药学院天然药物化学 博士
2011.09—2012.09 明尼苏达大学双城校区（美国） 博士联合培养
2003.09—2008.06 山东大学生命科学学院生物技术专业（国家生物基地） 本科

研究领域

1.天然产物的抗真菌活性研究：
对从苔藓、地衣及地衣内生真菌中得到的化学成分进行抗真菌活性筛选，并对其抗真菌的作用机理从分子层次上进行揭示。
2.真菌耐药的机理研究：
寻找真菌耐药基因，筛选克服真菌耐药的小分子，并对其耐药逆转机理进行研究。
3.真菌耐受的调控机制研究：
耐受不同与耐药，它是复发性感染的重要原因之一，耐受调控机理的揭示对于针对性设计克服耐受的药物具有重要的指导意义。

近期论文

1.Wenqiang Chang, Ming Zhang, Sha Zheng, Ying Li, Xiaobin Li, Wei Li, Gang Li, Zhaomin Lin, Zhiyu Xie, Zuntian Zhao and Hongxiang Lou. Trapping toxins within lipid droplets is a resistance mechanism in fungi.Scientific Reports,(2015). 15133.
2.Wenqiang Chang, Ming Zhang, Ying Li, Hongxiang Lou. A Flow Cytometry Based Method to Detect Persisters inCandida albicans. Antimicrobial Agents and Chemotherapy, (2015). 59，5044 –5048
3.Wenqiang Chang, Ming Zhang, Ying Li, Xiaobin Li, Yanhui Gao, Zhiyu Xie, Hongxiang Lou. Lichen endophyte derived pyridoxatin inactivates Candida growth by interfering with ergosterol biosynthesis.Biochimica et Biophysica Acta (BBA)-General Subjects, (2015). 1850(9), 1762-1771.
4. Xiao-Bin Li1,Wen-Qiang Chang1, Sha Zheng, Wei Li, Hong-Xiang Lou, The cleavage of perylenequinones through photochemical oxidation acts as a detoxification mechanism for the producer,RSC Advances, (2015). 5, 28187–28189 (first co-author).
5. Ying Li1,Wenqiang Chang1, Ming Zhang, Ying Zhao, Hongxiang Lou. Natural Product Solasodine-3-O-β-D-glucopyranoside Attenuates the Virulence ofCandida albicans.FEMS yeast research, (2015). 15(6) (first co-author).
6.W. Q. Chang, Y. Li, L. Zhang, A. Cheng, H. Lou, Retigeric Acid B Attenuates the Virulence ofCandida albicansvia Inhibiting Adenylyl Cyclase Activity Targeted by Enhanced Farnesol Production,PloS one, (2012). 7, e41624.
7.W. Chang, Y. Li, L. Zhang, A. Cheng, Y. Liu, H. Lou, Retigeric acid B enhances the efficacy of azoles combating the virulence and biofilm formation ofCandida albicans, Biological & pharmaceutical bulletin, (2012). 35, 1794-1801.
8.W.Q. Chang, X.Z. Wu, A.X. Cheng, L. Zhang, M. Ji, H.X. Lou, Retigeric acid B exerts antifungal effect through enhanced reactive oxygen species and decreased cAMP,Biochimica et Biophysica Acta (BBA)-General Subjects, (2011). 1810, 569-576.
9. Ying Li,Wenqiang Chang, Ming Zhang, Xiaobin Li, Yang Jiao, Hongxiang Lou. Diorcinol D Exerts Fungicidal Action againstCandida albicansthrough Cytoplasm Membrane Destruction and ROS Accumulation.PloS one, (2015). 10(6), e0128693.
10. Ying Li,Wenqiang Chang, Ming Zhang, Xiaobin Li, Yang Jiao, Hongxiang Lou. Synergistic and drug-resistant reversing effects of diorcinol D combined with fluconazole againstCandida albicans.FEMS yeast research, (2015).15(2).