个人简历

教育背景\r
博士2008.10-2013.02德国萨尔大学药物生物技术\r
硕士2005.09-2008.07 西北农林科技大学 植保资源利用\r
学士2001.09-2005.07 西北农林科技大学 植物保护\r
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工作经历\r
起止时间 单位名称 专业技术职务\r
2015.07-至今 山东大学微生物技术国家重点实验室 教授、博导\r
2014.10-2015.06 山东大学生命科学学院 副研究员\r
2013.02-2014.09 德国亥姆霍兹萨尔药物研究所 博士后

研究领域

"""""1.微生物基因组编辑技术\r
2.微生物天然产物挖掘与改造\r
3. 微生物天然产物组合生物合成及合成生物学"

近期论文

Shen Q#, Zhou H#, Dai G, Zhong G, Huo L, Li A, Liu Y, Yang M, Ravichandran V, Zheng Z, Tang YJ, Jiao N, Zhang Y,Bian X*. Characterization of a Cryptic NRPS Gene Cluster in Bacillus velezensis FZB42 Reveals a Discrete Oxidase Involved in Multithiazole Biosynthesis.ACS Catalysis. 2022, 12(6): 3371-3381.\r
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Wang X#, Zheng W#, Zhou H, Tu Q, Tang YJ, Stewart AF*, Zhang Y*,Bian X*. Improved dsDNA recombineering enables versatile multiplex genome engineering of kilobase-scale sequences in diverse bacteria.Nucleic Acids Res. 2022, 50(3): e15.\r
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Zhang X, Xu X, You C, Yang C, Guo J, Sang M, Geng C, Cheng F, Du L, Shen Y, Wang S, Lan H, Yang F, Li Y, Tang YJ, Zhang Y,Bian X*, Li S*, Zhang W*. Biosynthesis of chuangxinmycin featuring a deubiquitinase-like sulfurtransferase.Angew Chem Int Ed. 2021,60(46): 24418-24423. Recommended in Faculty OpinionsandNPR “Hot off the press”\r
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Liu J, Zhou H, Yang Z, Wang X, Chen H, Zhong L, Zheng W, Niu W, Wang S, Ren X, Zhong G, Wang Y, Ding X, Müller R, Zhang Y,Bian X*. Rational construction of genome-reduced Burkholderiales chassis facilitates efficient heterologous production of natural products from proteobacteria.Nat Commun. 2021,12: 4347. DOI : 10.1038/s41467-021-24645-0.\r
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Zhong L#,DiaoX#,Zhang N#, Li F, Zhou H, Chen H, Bai X, Ren X, Zhang Y*, Wu D*,Bian X*.Engineering and Elucidation of the Lipoinitiation Process in Nonribosomal Peptide Biosynthesis.Nat Commun.2021, 12: 296.被Nat Commun编辑选为高亮文章.\r
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Chen H, Sun T, Bai X, Yang J, Yan F, Yu L, Tu Q, Li A, Tang Y, Zhang Y*,Bian X*, Zhou H*. Genomics-Driven Activation of Silent Biosynthetic Gene Clusters inBurkholderia gladioliby Screening Recombineering System.Molecules. 2021,26(3): 700.\r
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Ouyang Q, Wang X, Zhang N, Zhong L, Liu J, Ding X, Zhang Y,Bian X*. Promoter screening facilitates heterologous production of complex secondary metabolites in Burkholderiales strains.ACS Synth Biol.2020, 9(2):457-460.\r
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Wang ZJ, Zhou H, Zhong G, Huo L, Tang YJ, Zhang Y*,Bian X*. Genome Mining and Biosynthesis of Primary Amine-Acylated Desferrioxamines in a Marine Gliding Bacterium.Org Lett. 2020, 22(3): 939-943.\r
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Zhong, L.; Ravichandran, V.; Zhang, N.; Wang, H.;Bian, X*; Zhang, Y*; Li, A*. Attenuation of Pseudomonas aeruginosa Quorum Sensing by Natural Products: Virtual Screening, Evaluation and Biomolecular Interactions.Int J Mol Sci2020, 21, 2190.\r
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Chen H#, Zhou H#, Sun T, Xu J, Tu Q, Yang J, Zhang Y,Bian X*. Identification of holrhizins E-Q reveals the diversity of nonribosomal lipopeptides in Paraburkholderia rhizoxinica.J Nat Prod.2020, 83(2):537-541.\r
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Zheng W#, Wang X#, Zhou H, Zhang Y*, Li A*,Bian X*. Establishment of recombineering genome editing system in Paraburkholderia megapolitana empowers activation of silent biosynthetic gene clusters.Microb Biotechnol.2020, 13(2): 397-405.被Microb Biotechnol（2020, 13:1702-1704）的Highlight栏目重点介绍。\r
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Jing X#, Cui Q#, Li X, Yin J, Ravichandran V, Pan D, Fu J, Tu Q, Wang H*,Bian X*, Zhang Y*. Engineering Pseudomonas protegens Pf-5 to improve its antifungal activity and nitrogen fixation.Microb Biotechnol. 2020, 13(1): 118-133.\r
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Huo L, Hug JJ, Fu C,Bian X*, Zhang Y*, Müller R*. Heterologous expression of bacterial natural product biosynthetic pathways.Nat Prod Rep.2019, 36(10):1412-1436.入选ESI热点论文和高被引论文\r
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Wang X#, Zhou H#, Chen H#, Jing X, Zheng W, Li R, Sun T, Liu J, Fu J, Huo L, Li YZ, Shen Y, Ding X, Müller R,Bian X*, Zhang Y*. Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species.Proc Natl Acad Sci U S A. 2018, 115 (18): E4255-E4263.被Curr Opin Microbiol (2019, 51: 9-15)和Curr OpinChemBiol（2021, 60: 47-54）推荐。\r
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Xu X, Zhou H, Liu Y, Liu X, Fu J, Li A, Li YZ, Shen Y,Bian X*, Zhang Y*. Heterologous Expression Guides Identification of the Biosynthetic Gene Cluster of Chuangxinmycin, an Indole Alkaloid Antibiotic.J Nat Prod. 2018, 81(4): 1060-1064.\r
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Chen X, Fang Q, Tu Q, Liu C, Yin J, Yin Y, Xia L,Bian X*, Zhang Y*. Identification of a contact-dependent growth inhibition system in the probiotic Escherichia coli Nissle 1917.FEMS Microbiol Lett.2018; 365(11): fny102.\r
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Bian X#, Tang B#, Yu Y, Tu Q, Gross F, Wang H, Li A, Fu J, Shen Y, Li YZ, Stewart AF, Zhao G, Ding X*, Müller R*, Zhang Y*.Heterologous production and yields improvement of epothilones in the Burkholderiales strain DSM 7029.ACS Chem Biol.2017; 12 (7): 1805-1812. Highlight inHot off the Press of Natural Product Reports(Nat. Prod. Rep., 2017, 34, 1180-1184).\r
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Bian X, Plaza A, Zhang Y*, Müller R*. Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moiety.Chem Sci.2015, 6(5): 3154-3160,\r
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Bian X, Plaza A, Yan F, Zhang Y*, Müller R*.Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide derivatives in vivo.Biotechnol Bioeng.2015 Jul;112(7):1343-1353.\r
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Bian X, Huang F, Wang H, Klefisch T, Müller R*, Zhang Y*.Heterologous production of glidobactins/luminmycins in Escherichia coli Nissle containing the glidobactin biosynthetic gene cluster from Burkholderia DSM7029.ChemBioChem. 2014, 15(15): 2221-2224.\r
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Ongley SE#,Bian X#, Neilan BA*, Müller R*. Recent advances in the heterologous expression of microbial natural product biosynthetic pathways.Nat Prod Rep. 2013, 30(8):1121-1138.\r
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Bian X, Fu J, Plaza A, Herrmann J, Pistorius D, Stewart AF, Zhang Y*, Müller R*.In vivo evidence for a prodrug activation mechanism during colibactin maturation.ChemBioChem. 2013, 14(10):1194-1197.\r