个人简历

1983-1987年于四川大学生物系获理学学士学位;1987-1990年于中国科学院武汉病毒研究所获理学硕士学位;1998-2002年于香港中文大学获博士学位。1990-1998就职于四川大学生物工程系，副教授; 2002-2007年就职于四川大学华西医院肺癌分子生物学研究室，教授，硕士研究生导师; 2007年-至今就职于四川大学华西医院生物治疗国家重点实验室，教授， 2007年遴选为博士研究生导师。

研究领域

1. 肺癌生物治疗（基因治疗、疫苗、抗体等）的基础及应用研究 2. 肺癌发生和转移的分子机制研究(基因,非编码RNA) 3. 肺癌干细胞相关研究 4. 抗肿瘤新药筛选及药理机制研究

近期论文

1.Xixian Ke, Yue Yuan, Chenglin Guo, Yan Yang, Qiang Pu, Xueting Hu, Kui Tang, Xinmei Luo, Qianqian Jiang, Xiaolan Su, Lunxu Liu, Wen Zhu*, Yuquan Wei. MiR-410 induces stemness by inhibiting Gsk3β but upregulating β-catenin in non-small cells lung cancer. Oncotarget.2017;8:11356-11371.Doi10.18632/oncotarget.14529 2. Xuchao Zhang, Xixian Ke, Qiang Pu, Yue Yuan, Weihan Yang, Xinmei Luo, Qianqian Jiang, Xueting Hu,Yi Gong, Kui Tang , Xiaolan Su, Lunxu Liu, Wen Zhu*,Yuquan Wei. MicroRNA-410 acts as oncogene in human non-small cell lung cancer(NSCLC) through targeting SLC34A2 and affecting Wnt/β-catenin pathway. Oncotarget,2016,7: 14569-14585, DOI: 10.18632/oncotarget.7538 3.Yu Wang, Weihan Yang, Qiang Pu, Yan Yang, Sujuan Ye, Qingping Ma, Jiang Ren, Zhixing Cao,Guoxing Zhong, Xuechao Zhang, Lunxu Liu and Wen Zhu*. The effects and mechanisms of SLC34A2 in tumorigenesis and progression of human non-small cell lung cancer. Journal of Biomedical Science. 2015, 22:52 4.Guoxing Zhong, Yi Gong, Chuanjiang Yu, Shifei Wu,Qingping Ma, Yu Wang, Jiang Ren, Xuechao Zhang,Weihan Yang, Wen Zhu*. Significantly inhibitory effects of low molecular weight heparin (Fraxiparine) on the motility of lung cancer cells and its related mechanism. Tumor Biol. 2015, 36,4689-4687 5.Jiang Ren, Chuanjiang Yu, Shifei Wu, Feng Peng, Qianqian Jiang, Xuechao Zhang,Guoxing Zhong, Huashan Shi, Xiang Chen, Xiaolan Su, Xinmei Luo, Wen Zhu* and Yuquan Wei. Cationic Liposome Mediated Delivery of FUS1 and hIL-12 Coexpression Plasmid Demonstrates Enhanced Activity against Human Lung Cancer. Current Cancer Drug Targets, 2014, 14, 167-180 6.Lingdong Li, Chuanjiang Yu, Jiang Ren, Sujuan Ye, Wenjing Ou, Yu Wang, Weihan Yang , Guoxing Zhong, Xiang Chen, Huashan Shi, Xiaolan Su, Lijuan Chen, Wen Zhu*. Synergistic effects of eukaryotic coexpression plasmid carrying LKB1 and FUS1 genes on lung cancer in vitro and in vivo. Journal of Cancer Research and Clinical Oncology, 2014，140(6):895-907. 7.Qingping Ma, Qianqian Jiang, Qiang Pu, Xuechao Zhang, Weihan Yang, Yu Wang,SujuanYe, Shifei Wu, Guoxing Zhong, Jiang Ren, Yan Zhang, Lunxu Liu and Wen Zhu* . MicroRNA-143 inhibits migration and invasion of human non-small-cell lung cancer and its relative mechanism. International Journal of Biological Sciences. 2013; 9(7):680-692. 8.Wenjing Ou, Sujuan Ye, Weihan Yang, Yu Wang, Qingping Ma, Chuanjiang Yu, Huashan Shi, zhu Yuan, Guoxing Zhong, Jiang Ren, Wen Zhu*. Enhanced antitumor effect of cisplatin in human NSCLC cells by tumor suppressor LKB1. Cancer Gene Therapy, 2012 Jul;19(7):489-98 9.Qing-Dong Huang, Guo-Xing Zhong, Yang Zhang, Jiang Ren, Yun Fu, Ji Zhang, Wen Zhu* Xiao-Qi Yu. Cyclen-Based Cationic Lipids for Highly Efficient Gene Delivery towards Tumor Cells. Plos ONE，2011,6(8):1-11 10.Shuo Li,Yu Wang，Ji Zhang, Wei-Han Yang, Zhen-Hua Dai,Wen Zhu*and Xiao-Qi Yu.Biodegradable cross-linked poly(amino alcohol esters) based on LMW PEI for gene delivery. Molecular BioSystems, 2011,7,1254–1262 11.Qing-Dong Huang，Wen-Jing Ou, Hong Chen，Zhi-Hua Feng, Jing-Yi Wang, Ji Zhang，Wen Zhu* ,Xiao-Qi Yu. Novel cationic lipids possessing protonated cyclen and imidazolium salt for gene delivery. European Journal of Pharmaceutic and Pharmaceutics,2011,78:326-355