个人简历

教育及工作经历 2005.09-2009.06 四川大学华西药学院，理学学士 2009.09-2014.06 四川大学华西药学院，药物化学 博士 (导师：陈应春教授) 2014.10-2015.10 瑞典皇家理工学院 (KTH) 化学工程学院 博士后 (导师：Cristina Moberg教授) 2015.12-2017.01 美国德雷塞尔大学 （Drexel University）药理与生理系 博士后 (导师：Joseph. Salvino教授) 2017.02-2018.06 美国 Wistar 研究所分子筛选癌症研究中心 博士后, (导师：Joseph. Salvino教授) 2018.07-至今 四川大学华西药学院，药物化学系，特聘副研究员

研究领域

1.基于氯霉素碱的新型结构催化剂的合成与应用研究 2.新型有机硼化合物的不对称合成及应用研究 3.基于蛋白靶向嵌合分子技术策略的抗肿瘤药物研究 4.靶向金属β-内酰胺酶的新型抑制剂的设计合成及活性研究 5.不对称合成方法学研究

近期论文

1.You-Cai Xiao, Chistina Moberg*, “Silaborative Carbocyclizations of 1,7-Enynes. Diastereoselective Preparation of Chromane Derivatives”, Org. Lett. 2016, 18, 308. (Highlighted by Synfacts, 2016, 12, 0399.) 2.Xiao-Long He, You-Cai Xiao, Wei Du, Ying-Chun Chen*, “Enantioselective Formal [3+3] Cycloadditions of Ketones and Cyclic 1-Azadienes by Cascade Enamine-Enamine Catalysis”, Chem.-Eur J. 2015, 21, 3443. 3.You-Cai Xiao, Cai-Zhen Yue, Peng-Qiao Chen, Ying-Chun Chen*, “Asymmetric Dearomatic Diels–Alder Reactions of Diverse Heteroarenes via π-System Activation”, Org. Lett. 2014, 16, 3028. 4.Peng-Qiao Chen, You-Cai Xiao, Cai-Zhen Yue, Ying-Chun Chen*, “Trienamine catalysis with linear deconjugated 3,5-dienones”, Org. Chem. Front. 2014, 1, 490. 5.Qing-Qing Zhou, You-Cai Xiao, Xin Yuan, Ying-Chun Chen*, “Asymmetric DielsAlder Reactions of 2,4,6-Trienals via Tetraenamine Catalysis”, Asian. J. Org. Chem. 2014, 3, 545. 6.Jun-Long Li, Cai-Zhen Yue, Peng-Qiao Chen, You-Cai Xiao, Ying-Chun Chen*, “Remote Enantioselective FriedelCrafts Alkylations of Furans via HOMO-Activation”, Angew. Chem. Int. Ed. 2014, 53, 5449. 7.Qing-Qing Zhou, Xin Yuan, You-Cai Xiao, Lin Dong, Ying-Chun Chen*, “Aminocatalytic Asymmetric DielsAlder Reaction of Phosphorus Dienophiles and 2,4-Dienals”, Tetrahedron. 2013, 69, 10369. 7.You-Cai Xiao, Ying-Chun Chen, Comprehensive Enantioselective Organocatalysis: Chapter 36: Intramolecular Reactions (pages 1067-1090) (Dalko, P. I. Ed), Wiley-VCH, Weinheim, 2013 8.You-Cai Xiao, Qing-Qing Zhou, Lin Dong, Tian-Yu Liu, Ying-Chun Chen*, “Asymmetric DielsAlder Reaction of 2-Methyl-3-indolyl methanols via in situ Generation of ortho-Quinodimethanes (oQDMs)”, Org. Lett. 2012, 14, 5940. (Highlighted by Synfacts, 2013, 9, 212.) 9.You-Cai Xiao, Chao Wang, Yuan Yao, Jian Sun*, Ying-Chun Chen*, “Direct Asymmetric Hydrosilylation of Indoles: Combined Lewis Base and Brønsted Acid Activation”, Angew. Chem. Int. Ed. 2011, 50, 10661. (Highlighted by Synfacts, 2011, 12, 1360.) 10.Bo Han, Jun-Long Li, You-Cai Xiao, Si-Li Zhou, and Ying-Chun Chen*, “Thiourea-Catalyzed Asymmetric Mannich-Type Reactions”, Curr. Org. Chem. 2011, 15, 4128. 11.Bo Han, You-Cai Xiao, Yuan Yao, Ying-Chun Chen* “Lewis Acid Catalyzed Intramolecular Direct Ene Reaction of Indoles”, Angew. Chem. Int. Ed. 2010, 49, 10189. 12.Bo Han, You-Cai Xiao, Zhao-Quan He, Ying-Chun Chen* “Asymmetric Michael Addition of γ,γ-Disubstituted α,β-Unsaturated Aldehydes to Nitroolefins via Dienamine Catalysis”, Org. Lett. 2009, 11, 4660.