研究领域

1)Cell polarity and directed migration 2) Neutrophil-mediated inflammation and autoimmune diseases 3) Neutrophil-promoted tumor growth

近期论文

1. Wang G, Cao L, Liu X, Sieracki N, Di A, Wen X, Chen Y, Taylor S, Huang X, Tiruppathi C, Zhao Y, Gao X, Tin J, Bai C, Malik AB and Xu J. (2016) Oxidant sensing by TRPM2 inhibits neutrophil migration and mitigates inflammation. Dev. Cell 38, 453-62. 2. Liu X, Yang T, Suzuki K, Tsukita S, Ishii M, Zhou S, Wang G, Cao L, Qian F, Taylor S, Oh M, Levitan I, Ye RD, Carnegie GK, Zhao Y, Asrar MB and Xu J. (2015). Moesin and myosin phosphatase confine neutrophil orientation in a chemotactic gradient. J. Exp. Med. 212, 267-80. 3. Liu X, Ma B, Malik AB, Tang H, Yang T, Sun B, Wang G, Minshall RD, Li Y, Zhao Y, Ye RD and Xu J. (2012). Bidirectional regulation of neutrophil migration by MAP kinases. Nature Immunology. 13, 457-64. 4. Xu J, Gao X, Ramchandran R, Zhao Y, Vogel SM, and Malik AB. (2008). Non-muscle myosin light chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by the activation of b2 integrins. Nature Immunology. 9, 880-6. (co-corresponding author) 5. Xu J, Keymeulen AV, Wakida NM, Carlton P, Berns MW, Bourne HR. (2007). Polarity reveals intrinsic cell polarity. Proc Natl Acad Sci U S A. 104, 9296-300. (co-corresponding author) 6. Xu J, Wang F, Keymeulen AV, Rentel M, and Bourne HR. (2005). Neutrophil microtubules suppress polarity and enhance directional migration. Proc Natl Acad Sci U S A. 102, 6884-9. 7. Xu J, Wang F, Keymeulen AV, Herzmark P, Straight AF, Kelly K, Takuwa Y, Sugimoto N, Mitchison TJ, and Bourne HR. (2003). Divergent signals and cytoskeletal assemblies regulate self-organizing polarity in neutrophils. Cell. 114, 201-14. 8. Xu J, Rodrigues D, Petitclerc E, Kim JJ, Hangai M, Davis GE, and Brooks PC. (2001) Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo. J. Cell. Biol. 154, 1069-79.