个人简历

2002年在四川大学获工学博士学位。2007-2008年在美国Western Michigan University进修访问，师从著名学者莫亦荣教授，开展了QM/MM分子动力学模拟、基于酶靶点的药物设计、小分子间相互作用能的定量分解、质子转移研究等方面的研究工作。

研究领域

长期从事与物理化学实验相关的信号的微机检测、实验装置的计算机控制、实验内容的更新等工作

近期论文

1.Xiang Gao, Shimin Wang, BiLan Wang, Senyi Deng, Xiaoxiao Liu, XiaoNing Zhang, LinLi Luo, RangRang Fan, MingLi Xiang*, Chao You, YuQuan Wei, ZhiYong Qian, Gang Guo*. Improving the anti-ovarian cancer activity of docetaxel with biodegradable self-assembly micelles through various evaluations. Biomaterials 2015, 53: 646-658 2.Guo-Bo Li, Ling-Ling Yang, Yiming Yuan, Jun Zou*, Yu Cao, Sheng-Yong Yang, Rong Xiang, Mingli Xiang*. Virtual screening in small molecule discovery for epigenetic targets. Methods 2015, 71: 158-166 3.Lijuan Chen, Liwei Tan, Xiaoning Zhang, Jun Li, Zhiyong Qian,*, Mingli Xiang,*, Yuquan Wei. Which polymer is more suitable for etoposide: A comparison between two kinds of drug loaded polymeric micelles in vitro and in vivo? Int J Pharm 2015，495：265–275 4.Chengle Li, Jing Yao, Tian C. Zhang, Wenya Xing, Ying Liang, Mingli Xiang. Simultaneous removal of nitrogen and phosphorus by cetylpyridinium bromide modified zeolite. Water Sci Techno. 2017, DOI: 10.2166/wst.2017.459 5.Maling Gou, Xin Qu, Wei Zhu, Mingli Xiang, Jun Yang, Kang Zhang, Yuquan Wei & Shaochen Chen. Bio-inspired detoxification using 3D-printed hydrogel nanocomposites. Nature Communications. 2014, 5:3774 6.Mingfeng Shao, Yiming Yuan, Kun Yu, Kai Lei, Guonian Zhu, Lijuan Chen, Mingli Xiang*. Discovery and identification of PIM-1 kinase inhibitors through a hybrid screening approach. Mol Diver 2014, 18(2):335-344 7.Changyang Gong,*Yongmei Xie,Qinjie Wu,Yujun Wang, Senyi Deng,Dake Xiong,Lei Liu,Mingli Xiang*, Zhiyong Qian andYuquan Wei. Improving anti-tumor activity with polymeric micelles entrappingpaclitaxel in pulmonary carcinoma. Nanoscale 2012,4:6004–6017 8.Liang Ma, Caifeng Xie, Yinghua Ma, Juan Liu, Mingli Xiang *, Xia Ye, Hao Zheng, Zhizhi Chen, Qinyuan Xu, Tao Chen, Jinying Chen, Jincheng Yang, Neng Qiu,Guangcheng Wang, Xiaolin Liang, Aihua Peng, Shengyong Yang, Yuquan Wei, and Lijuan Chen*. Synthesis and biological evaluation of novel 5-benzylidenethiazolidine-2, 4-dione derivatives for the treatment of inflammatory diseases. J Med Chem 2011, 54(7): 2060-2068 9.C Gong, S Deng, Q Wu, M Xiang, X Wei, L Li, X Gao. Improving antiangiogenesis and anti-tumor activity of curcumin by biodegradable polymeric micelles. Biomaterials 2013, 34: 1413-1432 10. Mingli Xiang,* Kai Lei, Wenjie Fan, Yuchun Lin, Gu He, Mingli Yang, Lijuan Chen, and Yirong Mo. In silico identification of EGFR-T790M inhibitors with novel scaffolds: start with extraction of common features. Drug Des Devel Ther 2013, 7: 789–839. 11. Lulu Cai, Neng Qiu, Mingli Xiang, Rongsheng Tong, Junfeng Yan, Lin He, Jianyou Shi, Tao Chen, Jiaolin Wen, Wenwen Wang, and Lijuan Chen. Improving aqueous solubility and antitumor effects by nanosized gambogic acid-mPEG2000 micelles. Int J Nanomedicine 2014, 9: 243–255 12. Caifeng Xie, Liang Ma, Juan Liu, Xiuxia Li, Heying Pei, Mingli Xiang*, Lijuan Chen*. SKLB023 Blocks Joint Inflammation and Cartilage Destruction in Arthritis Models via Suppression of Nuclear Factor-Kappa B Activation in Macrophage. PLoS One, 2013, 8(2): e56349 13. Xiang M*, Cao Y, Fan W, Chen L*, Mo Y. Computer-Aided Drug Design: Lead Discovery and Optimization. Comb Chem High T Scr, 2012，15(4)：328-337 14. Mingli Xiang*, Yuchun Lin, Gu He, Lijuan Chen*, Mingli Yang,Shengyong Yang, Yirong Mo. Correlation between biological activity and binding energy in systems of integrin with cyclic RGD-containing binders: a QM/MM molecular dynamics study. J Mol Model, 2012, 18: 4917–4927 15.Maling Gou,Ke Men,Huashan Shi,Mingli Xiang, Juan Zhang,Jia Song,Jianlin Long,Yang Wan, Feng Luo,Xia Zhao and Zhiyong Qian. Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo. Nanoscale, 2011, 3, 1558-1567