个人简历

2014年获得中国科学技术大学博士学位（导师：施蕴渝院士），2014年-2018年在美国UT Southwestern Medical Center从事博士后研究（合作导师：Daniel Rosenbaum）。2018年受聘于四川大学生物治疗国家重点实验室/华西医院肾脏病研究室，担任G蛋白偶联受体研究室主任。

研究领域

1，GPCR的别构调节机制；2，GPCR signaling 分子机制；3，GPCR先导化合物的设计和优化；4，GPCR单克隆抗体和纳米抗体的筛选

近期论文

1. Shao Z, Yin J, Chapman K, Grzemska M, Clark L, Wang J & Rosenbaum DM. High-resolution crystal structure of the human CB1 cannabinoid receptor. Nature. 2016, 540, 602–606. 2. Shao Z#, Yan W#, Peng J, Zuo X, Zou Y, Li F, Gong D, Ma R, Wu J, Shi Y. Zhang Z, Teng M, Li X & Gong Q. Crystal structure of tRNA m1G9 methyltransferase Trm10: insight into the catalytic mechanism and recognition of tRNA substrate. Nucleic Acids Research. 2014, 42, 509-525. 3. Shao Z, Li F, Sy SM, Yan W, Zhang Z, Gong D, Wen B, Huen MS, Gong Q, Wu J & Shi Y. Specific recognition of phosphorylated tail of H2AX by the tandem BRCT domains of MCPH1 revealed by complex structure. Journal of Structural Biology, 2012, 177, 459-468. 4. Yan W, Shao Z, Li F, Niu L, Shi Y, Teng M & Li X. Structural basis of gammaH2AX recognition by human PTIP BRCT5-BRCT6 domains in the DNA damage response pathway. FEBS Letter, 2011, 585, 3874-3879. 5. Zou Y, Shao Z, Peng J, Li F, Gong D, Wang C, Zuo X, Zhang Z, Wu J, Shi Y & Gong Q. Crystal structure of triple-BRCT-domain of ECT2 and insights into the binding characteristics to CYK-4. FEBS Letter, 2014, 588, 2911-2920. 6. Yin J, Babaoglu K, Brautigam CA, Clark L, Shao Z, Scheuermann TH, Harrell CM, Gotter AL, Roecker AJ, Renger JJ, Coleman PJ & Rosenbaum DM. Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors. Nature Structure & Molecular Biology. 2016, 23, 293-299. 7. Gong D, Yang F, Li F, Qian D, Wu M, Shao Z, Wu J & Shi Y. Crystal structure and functional characterization of the human RBM25 PWI domain and its flanking basic region. Biochem Journal, 2013, 450, 85-94.