个人简历

1985 年毕业于河北承德医学院医学系， 1992 年于苏州医学院获硕士学位， 92 年起，于大连大学附属中山医院从事风湿免疫工作，其间 1995-2000 年任该院风湿免疫科主任。 2000 年底赴加拿大蒙特利尔大学医学中心攻读博士学位， 2004 年获博士学位。博士毕业后在位于美国纽约州的 Trudeau 研究所 从事 博士后研究。 2007 年 2 月任美国德州大学助理教授，同年 10 月被华西医院一层次人才引进，任风湿免疫学教授并被遴选为博士生导师。多年来致力于风湿免疫病的临床与科研工作。发表高水平学术论文多篇。对风湿病的病因、发病机制有较深入的研究。目前主持国家自然基金重点项目继续围绕风湿病的发病机制和治疗进行研究。

研究领域

一、免疫调控与免疫耐受，免疫耐受的打破被认为是自身免疫性疾病产生的基础而诱导耐受又是移植免疫的重要研究课题。我们试图通过研究免疫细胞的调控来进一步认识免疫耐受以期达到发现自身免疫病诊断和治疗的新靶点。二、风湿病的病机和治疗学研究。从免疫学的角度研究风湿病的发病机制和探索免疫治疗的新途径

近期论文

[1] Xiaochun Wan, Jun Zhang, Hongyu Luo, Guixiu Shi, et al. (2002) A TNF family member reversely costimulatory signals in to human T cells. Journal of Immunology 169(12): 6813-21. [2] Guixiu Shi, et al. (2002) Mouse T cells receive costimulatory signals from LIGHT, a TNF family member. Blood . 100:3279. [3] Guixiu Shi, et al. (2003) Death Decoy Receptor DcR3/TR6 Inhibits in vitro and in vivo T-Cell Chemotaxis. Journal of immunology 171:3407 . [4] Xiaochun Wan, Guixiu Shi, et al. (2003) DcR3/TR6 Modulates immune cell interactions. Journal of Cellular Biochemistry. 89(3): 603 . [5] Yulian Wu, Bing Han, Hongyu Luo, Guixiu Shi, Jiangping Wu. (2004) Dipeptide Boronic Acid, a Novel Proteasome Inhibitor, Prevents Islet-Allograft Rejection. Transplantation . 78(3): 360 . [6] Guixiu Shi et al. (2005) Tumor vaccine based on cell surface expression of DcR3/TR6. Journal of immunology 174: 4727 . [7] Guixiu Shi, Genevieve S. Young, Kim Kusser1, James B. Kirkland, Troy D.Randall1 and Frances E. Lund. (2006) Increased sensitivity of CD38 deficient islet cells to DNA damage: Role for NAD and PARP-1. Molecular Medicine 12: s23 . [8] Santiago Partida-Sanchez, Andreas Gasser, Ralf Fliegert, Adriana Sumoza-Toledo1, Harivadan Bhagat, Guixiu Shi, Timothy F Walseth4, Andreas H Guse3 andFrances E Lund. (2006) CD38 enzymatic products cADPR and ADPR control Ca2+ influx and leukocyte chemotaxis through TRPM2 cation channels. Molecular Medicine 12: s19 . [9] Guixiu Shi, Santiago Partida-Sánchez, Michael Tighe, Michael T. Borchers, Melvin I. Simon, and Frances E. Lund. (2007) Identification of an alternative q-dependent chemokine receptor signal transduction pathway in dendritic cells a G and granulocytes. Journal of Experimental Medicine 204 (11): 2705-2718 . [10] Santiago Partida-Sanchez, Andreas Gasser, Ralf Fliegert, Guixiu Shi, Adriana Sumoza-Toledo, Harivadan Bhagat, Andreas H. Guse, Timothy F. Walseth4 and Frances E. Lund. (2007) Leukocyte chemotaxis is controlled by ADP-ribose, an activator of the TRPM2 cation channel. J ournal of Immunology, 2007, 179: 7827-7839 . [11] Partida-Danchez Santiago ; Rivero-Nava Laura ; Guixiu Shi; Frances E. Lund. (2007) CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses. Adv Exp Med Biol; 590:171-83 . [12] Guihua Zhu, Gang Liu, Yixin Liu, Qibing Xie, ,Guixiu Shi. (2009) Liver Abnormalities in Adult Onset Still's Disease: A Retrospective Study of 77 Chinese Patients. Journal of Clinical Rheumatology 15: 284-288.