个人简历

四川大学生物治疗国家重点实验室，研究员/教授、博士生导师。国家优秀青年科学基金获得者，青年长江学者，国家重点研发计划项目牵头人。担任中国生物工程学会青年工作委员会副主任委员，中国微生物学会医学微生物学与免疫学专业委员会委员，中国微生物学会医学微生物学与免疫学专委会青年学组常务委员。 2011年毕业于中国科学院微生物研究所，获得理学博士学位。2011年至2014年，在中国科学院微生物研究所任助理研究员。2014年至2015年在中国科学院微生物研究所任副研究员。2015年起受聘于四川大学生物治疗国家重点实验室，任研究员。

研究领域

1，病原侵入与致病机制研究。 2，病原与宿主互作的分子基础研究。 3，基于结构的疫苗设计和抗体改造。 4，基于结构的抗病毒靶点鉴定。 5，新型抗病毒药物的筛选与优化。

近期论文

1. Guangwen Lu#, Yawei Hu#, Qihui Wang#, Jianxun Qi#, Feng Gao#, Yan Li, Yanfang Zhang, Wei Zhang, Yuan Yuan, Jinku Bao, Buchang Zhang, Yi Shi, Jinghua Yan, George F. Gao*. Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature, 500(7461), pp 227, 2013. 2. Qiong Lu#, Guangwen Lu#, Jianxun Qi, Han Wang, Yifang Xuan, Qihui Wang, Yan Li, Yanfang Zhang, Chunfu Zheng, Zheng Fan, Jinghua Yan, George F. Gao*. Pilrα and pilrβ have a siglec fold and provide the basis of binding to sialic acid. Proceedings of the National Academy of Sciences of the United States of America, 111(22), pp 8221, 2014. 3. Xiaoai Zhang#, Guangwen Lu#, Jianxun Qi, Yan Li, Yan He, Xiang Xu, Jia Shi, Catherine W.-H. Zhang, Jinghua Yan, George F. Gao*. Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4. Nature Structural and Molecular Biology, 20(1), pp 67, 2013. 4. Guangwen Lu, Qihui Wang, George F. Gao. Bat-to-human: spike features determine ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV and beyond. Trends in Microbiology, 23(8), pp 468, 2015. 5. Guangwen Lu*, Di Liu. SARS-like virus in the Middle East: A truly bat-related coronavirus causing human diseases. Protein&Cell,3(11), pp 803, 2012. (corresponding author) 6. Qiong Lu, Hao Lu, Jianxun Qi, Guangwen Lu*, George F Gao*. An octamer of enolase from Strepotococcus suis. Protein&Cell, 3(10), pp 769, 2012. (shared corresponding author) 7. Na Zhang#, Jinhua Yan#, Guangwen Lu#, Zhengfei Guo, Zheng Fan, Jiawei Wang, Yi Shi, Jianxun Qi, George F. Gao*. Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion. Nature Communications, 2, pp 577, 2011. 8. Guangwen Lu#, Na Zhang#, Jianxun Qi, Yan Li, Zhujun Chen, Chunfu Zheng, George F. Gao, Jinghua Yan*. Crystal structure of Herpes simplex virus 2 gD bound to nectin-1 reveals a conserved mode of receptor recognition. Journal of Virology, 88(23), pp13678, 2014. 9. Guangwen Lu, Jianxun Qi, Zhujun Chen, Xiang Xu, Feng Gao, Daizong Lin, Wangke Qian, Hong Liu, Hualiang Jiang, Jinghua Yan, George F. Gao*. Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design. Journal of Virology, 85(19), pp 10319, 2011. 10. Guangwen Lu, Jianxun Qi, Feng Gao, Jinghua Yan, Jiaqi Tang, George F. Gao*. A novel \