个人简历
博士生导师，研究员，毕业于中科院成都生物研究所。
研究领域
主要从事计算机辅助靶向小分子抗肿瘤及 HIV 病毒药物的设计、合成及活性评价。
近期论文
Feng X, Zhou Z, Ma C, Yin X, Li R*, Dong L, Chen YC* Trienamines derived from interrupted cyclic 2,5-dienones:remote δ, ε-C=C bond activation for asymmetric Inverse-Electron-Demand Aza-Diels-Alder reaction. Angew. Chem. Int. Ed. 2013, 52: 14173 –14176 Zhou M, Luo H, Li R*, Ding ZY Exploring the binding mode of HIV-1 Vif inhibitors by blind docking, molecular dynamics and MM/GBSA. RSC Adv. 2013, 3: 22532 Zhang WJ, Li Z, Zhou M, Wu F, Hou XY, Luo H, Liu H, Han X, Yan GY, Ding ZY, Li R* Synthesis and biological evaluation of 4-(1,2,3-triazol-1-yl)coumarin derivatives as potential antitumor agents. Bioorg. Med. Chem. Lett. 2014, 24: 799–807 Ma C, Gu J, Teng B, Zhou QQ, Li R*, Chen YC* 1?Azadienes as Regio- and Chemoselective Dienophiles in Aminocatalytic Asymmetric Diels Alder Reaction Org. Lett. 2013, 24:6206–6209 Wu F, Hou XY, Luo H, Zhou M, Zhang WJ, Ding ZY, Li R*. Exploring the selectivity of PI3Ka and mTOR inhibitors by 3D-QSAR, molecular dynamics simulations and MM/GBSA binding free energy decomposition. MedChemComm. 2013,4: 1482 Han B, Liu QP, Li R*，Tian X, Xiong XF, Deng JG, Chen YC*. Discovery of Bifunctional Thiourea/Secondary-Amine Organocatalysts for the Highly Stereoselective Nitro-Mannich Reaction of a-Substituted Nitroacetates.Chem. Eur. J. 2008, 14, 8094 – 8097 Li Z, Zhou M, Wu F, Li R*, Ding ZY Self-organizing molecular field analysis on human beta-secretase onopeptide inhibitors:5,5-disubstituted aminohydantoins Eur. J. Med. Chem.,2011,46:58-64 Shi JY, Xu GB, Zhu W, Ye HY, Yang SY, Luo YF, Han J, Yang JC, Li R*, Chen LJ*, Wei YQ Design and synthesis of 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and pyrazolo[3,4-b]pyridines for Aurora-A kinase inhibitors. Bioo. Med. Chem. Lett. 2010, 20: 4273-4278. Feng X, Zhou Z, Yin X, Li R*, Chen YC*. Enantioselective Direct Bisvinylogous 1,6-Additions of β-Allyl-2-cyclohexenone to α,α-Dicyanodienes through Trienamine Catalysis. Eur. J. Org. Chem. 2014, 5906–5909 Luo H, Shi JY, Lu LF, Wu F, Zhou M, Hou XY, Li R* Molecular dynamics-based self-organizing molecular field analysis on 3-amino-6-arylpyrazines as the ataxia telangiectasia mutated and Rad3 related (ATR) protein kinase inhibitors, Med. Chem. Res., 2014, 23: 747-758. Hou XY, Luo H, Zhong H, Wu F, Zhou M, Zhang WJ, Han X, Yan GY, Zhang MQ, Lu LF, Ding ZY, He G*, Li R*. Analysis of furo[3,2-c]tetrahydroquinoline and pyrano[3,2-c]-tetrahydroquinoline derivatives as antitumor agents and their metabolites by liquid chromatography/electrospray ionization tandem mass spectrometry Rapid Commun. Mass Spectrom. 2013, 27, 1222–1230 He G, Qiu MH, Li R*, Song XR, Zheng X, Shi JY, Xu GB, Han J, Yu LT, Yang SY, Chen LJ, Wei YQ Molecular docking-based 3D-QSAR studies of pyrrolo [3, 4-c] pyrazole derivatives as Aurora-A inhibitors Mol. Simulat. 2011,37: 31- 42 Peng AH#, Li R#, Hu J, Chen LJ*, Zhao X, Luo HD, Ye HY, Yuan Y, Wei YQ, Flow rate gradient high-speed counter-current chromatography separation of five diterpenoids from Triperygium wilfordii and scale-up. J. Chromatography A, 1200, 2: 129-135. Li R*, Peng A H, He CM, Wang XH, Shi JY, Chen LJ, Wei YQ Analysis of triptophenolide and its related compounds from tripterygium wilfordii Hook.f by electrospray ionization tandem mass spectrometry. Int. J. Mass Spectrom. , 278,1: 38-49 Li R; Chen W; Shi JY; Chen LJ; Chen YC; Ding LS; Wei YQ. Design and synthesis a new bi(thiourea) Pd pincer guided by ESI-MS/MS Int. J. Mass Spectrom. 2008,43:542-546.
