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李炯
2023-05-12 13:03
  • 李炯
  • 李炯 - 研究员 博导-四川大学-生物治疗国家重点实验室-个人资料

近期热点

资料介绍

个人简历


四川大学生物系生物化学专业理学学士学位。四川大学生物化学与分子生物学专业理学硕士学位。四川大学生命科学院细胞生物学专业理学博士学位。美国密歇根大学访问学者。

研究领域


自身免疫性疾病及心血管、肿瘤等重大疾病免疫机制研究以及相关生物药物研发工作。

近期论文


1. Teng X,Hu ZL ,Wei XQ,Wang Z,Guan T,Liu N , Liu X, Ye N, Deng GH , Luo C, Zhou XK, Huang NY, Sun CY, Xu MY, Deng HX, Edwards,III CK, Chen XC, Wang XX, Cui KJ, Wei YQ,LiJ.IL-37 Ameliorates the Inflammatory Process in Psoriasis by Suppressing Proinflammatory Cytokines Production. J Immunol. 2014 Feb 15;192(4):1815-23. 2. Zhou X, Li J, Wang Z, Chen Z, Qiu J, Zhang Y, Wang W, Ma Y, Huang N, Cui K, Li J, Wei YQ. Cellular immunotherapy for carcinoma using genetically modified EGFR-specific T lymphocytes. Neoplasia. 2013 May;15(5):544-53. 3. Liu X, Wang Z, Ye N, Chen Z, Zhou X, Teng X, Huang N, Liu N, Zhang N, Guan T, Mao Y, Kan B, Wei Y, Li J. A protective role of IL-30 via STAT and ERK signaling pathways I n macrophage-mediated inflammation. Biochem Biophys Res Commun. 2013 May 31;435(2):306-12. 4. Hu Z, Chen Z, Huang N, Teng X, Zhang J, Wang Z, Wei X, Qin K, Liu X, Wu X, Tang H, Zhu X, Cui K, Li J. Expression, purification of IL-38 in Escherichia coli and production of polyclonal antibodies. Protein Expr Purif. 2015 Mar;107:76-82. 5. Wang Z, Zhou X, Li J, Liu X, Chen Z, Shen G, Guan T, Ye N, Wei X, Huang N, Yang L, Wei Y, Li J. Suppression of hepatoma tumor growth by systemic administration of the phytotoxin gelonin driven by the survivin promoter. Neoplasma. 2013;60(5):469-79. 6. X. Zhou, J. Qiu, Z. Wang, N. Huang, X. Li, Q. Li,, J. Li , In vitro and in vivo anti-tumor activities of anti-EGFR single-chain variable fragment fused with recombinant gelonin toxin , J Cancer Res Clin Oncol , 2012,138(7), pp 1081-90. 7. N. N. Zhang, N. Y. Huang, X. K. Zhou, X. L. Luo, C, J. Li , Protective effects of IL-4 on Bacillus Calmette-Guerin and lipopolysaccharide induced immunological liver injury in mice , Inflamm Res , 2012, 61(1), pp 17-26. 8. Zhou X, Li X, Gou M, Qiu J, Li J, Yu C, Zhang Y, Zhang N, Teng X, Chen Z, Luo C, Wang Z, Liu X, Shen G, Yang L, Qian Z, Wei Y, Li J. Antitumoral efficacy by systemic delivery of heparin conjugated polyethylenimine-plasmid interleukin-15 complexes in murine models of lung metastasis , Cancer Sci , 2011, 102(7), pp 1403-9. 9. Li J, Li X, Zhang Y, Zhou XK, Yang HS, Chen XC, Wang YS, Wei YQ, Chen LJ, Hu HZ, Liu CY. Gene therapy for psoriasis in the K14-VEGF transgenic mouse model by topical transdermal delivery of interleukin-4 using ultradeformable cationic liposome , JOURNAL OF GENE MEDICINE , 2010, 12(6), pp 481-490. 10. Zhang Y, Li J, Liu CY, Zhou XK, Qiu J, Zhang YB, Huang NY, Li Y, Chen XJ, Li XL, Wang YS, Yang HS, Chen XC, Kan B, Mao YQ, Deng HX, Yang L, Wen YJ, Zhao X, Wei YQ. , A Novel Transdermal Plasmid-Dimethylsulfoxide Delivery Technique for Treatment of Psoriasis , DERMATOLOGY, 2010, 221(1), pp 84-92. 11. Chen X, Zhang Y, Liu C, Zhang Y, Zhou X, Zhou T, Mao Y, Kan B, Wei YQ, Li J., Retinoic acid and dimethyl sulfoxide promote efficient delivery of transgenes to mouse skin by topically transdermal penetration , DRUG DELIVERY , 2010, 17(6), pp 385-390. 12. Ren X, Li J, Zhou X, Luo X, Huang N, Wang Y, Chen X, Wei Y. Recombinant Murine Interleukin 4 Protein Therapy for Psoriasis in a Transgenic VEGF Mouse Model , DERMATOLOGY , 2009, 219(3), pp 232-238 13 .Cui K, Zhou X, Luo J, Feng J, Zheng M, Huang D, Jiang J, Chen X, Wei Y, Li J, Yang L. Dual gene transfer of bFGF and PDGF in a single plasmid for the treatment of myocardial infarction. Exp Ther Med. 2014 Mar;7(3):691-696. 14. Zhang J, Liu X, Huang , Hu Z, Wu W, Teng X, Wang Z, Wei X, Tang H, Wu X, Chen Z, Li J, Li Z. Soluble expression and purification of the functional interleukin-30 protein in Escherichia coli. Prep Biochem Biotechnol. 2016 Aug 17;46(6):539-45. 15. Y. Yao, J. Li, Z. Lu, A. Tong, W. Wang, X. Su, Y., Y. Wei , Proteomic analysis of the interleukin-4 (IL-4) response in hepatitis B virus-positive human hepatocelluar carcinoma cell line HepG2.2.15 , Electrophoresis , 2011,32(15), pp 2004-12.

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