个人简历
发育细胞生物学研究员、教授 , 华西发育干细胞研究所所长。1986年上海第二军医大学获医学学士。1989年获解放军总医院血液病学硕士。1991到1994年在约翰霍普金斯大学做访问学者。 1999年获华盛顿大学神经生物学理学博士学位。1999到2005年在加州大学旧金山分校作博士后研究。2005到2007年在美国乔治亚州医学院分子医学和遗传学研究所任助理教授。2007年起任发育和干细胞研究所研究员、所长。学历和工作经历 1981-1986：上海第二军医大学海医系学员 1986-1989：解放军总医院硕士生 1989-1991：514 医院研究员。 1991-1994：美国约翰霍普金斯大学访问学者 1994-1999：美国华盛顿大学大学博士生 1999-2005：美国加州大学旧金山分校博士后 2005-2007：美国美国乔治亚州医学院任助理教授 2007-：四川大学教授
研究领域
神经干细胞的不对称性分裂、干细胞老化、肿瘤干细胞、神经微环路、血管发生与肿瘤、心肌干细胞与心衰。
近期论文
[1]Li, H-S., Yang, J.-M., Jacobson, R.D., Pasko, D. and Sundin, O. (1994). Pax-6 is first expressed in a region of ectoderm anterior to the early neural plate: implications for stepwise determination of the lens. Dev. Biol. 162, 181-194 [2]Li, H-S., Tierney, C., Wen, L., Wu, J. Y. and Rao, Y. (1997). A single morphogenetic field gives rise to two retina primordia under the influence of the prechordal plate. Development 124, 603-615 . [3]Li, H-S*., Chen, J-H*., Wu, W*., Fagaly, T., Zhou, L., Yuan, W., Dupuis, S., Jiang, Z-H, Nash, W., Gick, C., Ornitz, D.M., Wu. J.Y. and Rao, Y. (1999) Vertebrate Slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons. Cell 96, 807-818. * These authors contribute equally [4]Zhu, Y*., Li, H-S*., Zhou, L., Wu, J.Y. and Rao, Y. (1999). Cellular and molecular guidance of GABAergic neuronal migration from an extracortical origin to the neocortex. Neuron 23, 473-85. * These authors contribute equally. [5]Chen, J.H., Wu, W., Li, H-S., Fagaly, T., Zhou, L., Wu, J.Y., and Rao, Y. (2000). Embryonic expression and extracellular secretion of Xenopus slit. Neuroscience 96, 231-6. [6]Li, H-S., Wang, D, Shen, Q, Schonemann, M. D., Gorski, J.A., Jones, K. R., Temple, S., Jan, L.Y., and Jan, Y.N. (2003). Inactivation of numb and numblike in embryonic dorsal forebrain impairs neurogenesis and disrupts cortical morphogenesis. Neuron 40, 1105-18 [7]Huang, E.J., Li, H-S., Tang, A.A., Luo, E. J., Wiggins, A. K., Neve, R. L., Zhong, W., Jan, L. Y., and Jan, Y. N. (2005). Targeted deletion of numb and numblike in sensory neurons reveals their essential functions in axon arborization. Genes Dev. 19:138-51 [8]Rasin MR, Gazula VR, Breunig JJ, Kwan KY, Johnson MB, Liu-Chen S, Li HS, Jan LY, Jan YN, Rakic P, Sestan N. (2007). Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors.. Nat Neurosci. 10:819-27 [9]Lin, Q. Xiong, G.., Yang, J., Chen, M., Weinstein, L. S., Sun, Q., and Li, H-S. (2009). Gsa signaling controls asymmetric cell division of cortical progenitors by positioning polarity cues (submitted to Cell)
